**Figure 6.** Figure 2. (Reprinted with permission from Dove Medical Press, Ltd.). Eﬀect of FLLL32 and curcumin on IL-6-induced reduction of TEER in T84 monolayer. TEER value of T84 monolayers incubated with cell culture medium for 0–72 h in the presence of IL-6 (10 ng/mL) with FLLL32 (50 µM), curcumin (50 µM), or carrier (dimethyl sulfoxide) for 1 h in serum-free medium. ** p = 0.001 (IL-6 vs. IL-6 + FLLL32 at 24 h), **** p < 0.0001 (IL-6 vs. IL-6 + FLLL32 at 48 and 72 h), and # p = 0.003 (IL-6 vs. IL-6 + curcumin).

Deskripsi

FLLL32 (a curcumin analogue) and curcumin both protect against IL-6-induced reduction of transepithelial electrical resistance (TEER) in T84 cell monolayers. This graph shows that curcumin preserves intestinal barrier integrity by counteracting cytokine-mediated tight junction disruption over 72 hours.

More Figures from This Paper

Figure 5

TLR4/NF-kB/AP-1 signaling is a key inflammatory pathway in intestinal disease. This schematic illustrates the cascade from TLR4 receptor activation through NF-kB and AP-1 transcription factors to pro-inflammatory gene expression, and indicates where curcumin may intervene.

diagram

Figure 7

Curcumin's effects on intestinal tight junction proteins have been demonstrated in multiple experimental models. This figure presents protein expression or immunofluorescence data showing curcumin-mediated preservation of barrier function.

chart

Figure 8

Animal models of necrotizing enterocolitis and colitis respond favorably to curcumin treatment. This figure presents in vivo data on curcumin's protective effects in experimental intestinal inflammation.

chart

Figure 6

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Source Paper

Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection.

International journal of molecular sciences (2019)

PMID: 31003422

DOI: 10.3390/ijms20081912

Cite This Figure

![Figure 6: FLLL32 (a curcumin analogue) and curcumin both protect against IL-6-induced reduction of transepithelial electrical resistance (TEER) in T84 cell monolayers. This graph shows that curcumin preserves intestinal barrier integrity by counteracting cytokine-mediated tight junction disruption over 72 hours.](https://pdfs.citedhealth.com/figures/31003422/181.png)

> Source: Kathryn Burge et al. "Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protectio." *International journal of molecular sciences*, 2019. PMID: [31003422](https://pubmed.ncbi.nlm.nih.gov/31003422/)

<figure>
  <img src="https://pdfs.citedhealth.com/figures/31003422/181.png" alt="FLLL32 (a curcumin analogue) and curcumin both protect against IL-6-induced reduction of transepithelial electrical resistance (TEER) in T84 cell monolayers. This graph shows that curcumin preserves intestinal barrier integrity by counteracting cytokine-mediated tight junction disruption over 72 hours." />
  <figcaption>Figure 6. FLLL32 (a curcumin analogue) and curcumin both protect against IL-6-induced reduction of transepithelial electrical resistance (TEER) in T84 cell monolayers. This graph shows that curcumin preserves intestinal barrier integrity by counteracting cytokine-mediated tight junction disruption over 72 hours.<br>  Source: Kathryn Burge et al. "Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protectio." <em>International journal of molecular sciences</em>, 2019. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/31003422/">31003422</a></figcaption>
</figure>

Bukti Terkait

Curcumin untuk Chronic Inflammation

Peringkat A · 10 studi