What is the recommended dosage for Andrographis?

Acute: 400 mg 3x/day for up to 7 days; General: 200 mg standardized extract (30% andrographolides) 2x/day

What are the side effects of Andrographis?

Potential side effects include: Gastrointestinal discomfort (nausea, diarrhea), Headache, Fatigue, Allergic reactions (rare), Potential anti-fertility effects (high doses in animal studies).

What is andrographis and how does it support immune health?

Andrographis (Andrographis paniculata) is an herb traditionally used in Ayurvedic and Chinese medicine. Its active compound andrographolide has been studied for its potential to support upper respiratory health and modulate inflammatory responses.

What dosage of andrographis has been used in clinical studies?

Clinical trials have typically used standardized andrographis extracts providing 48–60 mg of andrographolides per day, often divided into multiple doses. Study durations generally range from 3 to 10 days for acute upper respiratory symptoms.

What are the potential side effects of andrographis?

Reported side effects include gastrointestinal discomfort, headache, and fatigue. Andrographis may have antiplatelet effects and should be used cautiously with blood-thinning medications. It is not recommended during pregnancy.

Andrographis

herb

Also known as: Andrographis paniculata, King of Bitters, Indian Echinacea, Kalmegh

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About

Andrographis paniculata (King of Bitters) is among the most evidence-backed herbal supplements for acute respiratory infections. Its active diterpene lactone andrographolide modulates NF-kB signaling, reduces pro-inflammatory cytokines, and enhances innate immune cell activity with both immune-stimulating and anti-inflammatory properties.

How It Works

Andrographolide modulates NF-kB signaling, reduces pro-inflammatory cytokines, and enhances innate immune cell activity; exhibits both immune-stimulating and anti-inflammatory properties.

Evidence For Conditions

Condition	Grade	Studies	Participants
Upper Respiratory Tract Infections	B	7	800	View →

Side Effects

Gastrointestinal discomfort (nausea, diarrhea)
Headache
Fatigue
Allergic reactions (rare)
Potential anti-fertility effects (high doses in animal studies)

Drug & Supplement Interactions

Anticoagulant and antiplatelet drugs (may increase bleeding risk)
Antihypertensive medications (additive blood pressure lowering)
Immunosuppressant medications (may counteract immunosuppression)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Astragalus Echinacea Elderberry Garlic Olive Leaf Extract

Quick Facts

Dosage: Acute: 400 mg 3x/day for up to 7 days; General: 200 mg standardized extract (30% andrographolides) 2x/day
Forms: capsule tablet liquid extract
Natural Sources: South/Southeast Asian plant (supplement form only)
Upper Limit: No established UL; short-term use (<14 days)
Best Time: At first sign of symptoms; with meals

Evidence Summary

Upper Respiratory Tract Infections B

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.