What is the recommended dosage for Beta-Glucan?

General: 250-500 mg/day; Immune Support: 250-750 mg/day

What are the side effects of Beta-Glucan?

Potential side effects include: Generally very well tolerated, Mild gastrointestinal effects (bloating), Allergic reactions in yeast-sensitive individuals.

What is beta-glucan and how does it support immune function?

Beta-glucans are polysaccharides found in yeast, oats, and mushrooms. They are recognized by immune cell receptors (Dectin-1) and have been studied for their potential to prime innate immune responses, including macrophage and natural killer cell activation.

What dosage of beta-glucan has been used in immune studies?

Clinical trials have used yeast-derived beta-1,3/1,6-glucan at doses of 250–500 mg per day. Oat beta-glucan studies typically use 3–6 g per day. The source and molecular structure significantly influence immune activity.

What are the potential side effects of beta-glucan?

Beta-glucan supplements are generally well tolerated. Some individuals may experience mild bloating or gas. People with yeast allergies should avoid yeast-derived beta-glucan and consider oat or mushroom-derived alternatives.

Beta-Glucan

other

Also known as: Beta-1,3/1,6-Glucan, Yeast Beta-Glucan, Baker's Yeast Beta-Glucan

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About

Yeast-derived 1,3/1,6-beta-D-glucans bind to Dectin-1 and complement receptor 3 on macrophages and neutrophils, triggering a trained innate immune response. A meta-analysis of 13 RCTs demonstrated significant reduction in URTI incidence, episodes, and duration. It is the most extensively researched supplemental form for trained immunity.

How It Works

1,3/1,6-beta-D-glucans bind Dectin-1 and complement receptor 3 on macrophages and neutrophils, triggering a trained innate immune response; enhance phagocytosis, cytokine production, and neutrophil oxidative burst.

Evidence For Conditions

Condition	Grade	Studies	Participants
Upper Respiratory Tract Infections	A	13	2000	View →

Side Effects

Generally very well tolerated
Mild gastrointestinal effects (bloating)
Allergic reactions in yeast-sensitive individuals

Drug & Supplement Interactions

Immunosuppressant medications (may counteract immunosuppression)
Generally few known drug interactions

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Bovine Colostrum Lactoferrin Spirulina

Quick Facts

Dosage: General: 250-500 mg/day; Immune_Support: 250-750 mg/day
Forms: capsule tablet powder
Natural Sources: Baker's yeast, Oats, Barley, Shiitake mushrooms
Upper Limit: No established UL
Best Time: On empty stomach for optimal immune activation

Evidence Summary

Upper Respiratory Tract Infections A

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.