What is the recommended dosage for N-Acetylcysteine?

General: 600-1,200 mg/day; Respiratory Support: 600 mg 2-3x/day

What are the side effects of N-Acetylcysteine?

Potential side effects include: Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form).

What is NAC and how does it support the immune system?

N-acetylcysteine (NAC) is a precursor to glutathione, the body's primary intracellular antioxidant. Studies have examined NAC for its potential to support respiratory health, reduce oxidative stress, and maintain immune cell function during illness.

What dosage of NAC has been studied for immune support?

Clinical trials have used NAC at doses of 600–1,800 mg per day, typically divided into two or three doses. For respiratory health outcomes, 600 mg twice daily is a commonly studied regimen over periods of 3 to 6 months.

What are the potential side effects of NAC?

Common side effects include nausea, vomiting, diarrhea, and an unpleasant sulfur taste. NAC may interact with nitroglycerin and certain blood pressure medications. Individuals with asthma should use caution, as inhaled NAC can trigger bronchospasm.

N-Acetylcysteine

amino_acid

Also known as: NAC, N-Acetyl-L-Cysteine, Acetylcysteine

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About

N-Acetylcysteine (NAC) is a direct precursor of glutathione, the body's master antioxidant. It replenishes intracellular glutathione to protect immune cells from oxidative damage, exhibits mucolytic activity to reduce respiratory mucus, and may modulate NF-kB signaling and inflammatory cascades.

How It Works

Direct precursor of glutathione; replenishes intracellular glutathione to protect immune cells from oxidative damage; exhibits mucolytic activity; may modulate NF-kB signaling and inflammatory cascades.

Evidence For Conditions

Condition	Grade	Studies	Participants
Acute Bronchitis	B	10	1500	View →
Post-Viral Fatigue	C	5	400	View →

Side Effects

Gastrointestinal discomfort (nausea, diarrhea)
Unpleasant sulfur taste/smell
Headache
Rare: bronchospasm (in asthma patients, inhaled form)

Drug & Supplement Interactions

Nitroglycerin (may enhance vasodilatory and headache effects)
Activated charcoal (reduces NAC absorption)
Anticoagulants (theoretical effect on platelet function)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Arginine Glutamine

Quick Facts

Dosage: General: 600-1,200 mg/day; Respiratory_Support: 600 mg 2-3x/day
Forms: capsule tablet effervescent tablet powder
Natural Sources: Poultry, Eggs, Dairy, Garlic, Onions, Cruciferous vegetables (as cysteine)
Upper Limit: No established UL; doses up to 1,800 mg/day widely studied
Best Time: Between meals on empty stomach for optimal absorption

Evidence Summary

Acute Bronchitis B

Post-Viral Fatigue C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.