EPs 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells.

W Beil, P Kilian

Other Phytomedicine : international journal of phytotherapy and phytopharmacology 2007 54 citazioni

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Study Design

Tipo di studio: In Vitro
Popolazione: None

Intervento: EPs 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells. None
Comparatore: None
Esito primario: EPs 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helic
Direzione dell'effetto: Mixed
Rischio di bias: Moderate

Abstract

Helicobacter pylori specifically adheres to gastric host cells, mainly based on carbohydrate-mediated cell-cell interaction. The extract of Pelargonium sidoides roots (EPs) 7630), a South African herbal remedy, is currently used to treat acute bronchitis. EPs 7630 prevents bacteria from attaching to cell membranes. Therefore, the ability of EPs 7630 to interfere with H. pylori growth and adhesion to gastric epithelial cells (AGS cells) was tested in vitro. EPs 7630 inhibited H. pylori growth and with higher potency adhesion to gastric AGS cells. EPs 7630 (50 and 100 microg/ml) reduced bacterial count attached to AGS cells by 77% and 91%, respectively. The results suggest that the mode of action of EPs 7630 is mainly related to its anti-adhesive activity.

TL;DR

The results suggest that the mode of action of EPs 7630 is mainly related to its anti-adhesive activity, which prevents bacteria from attaching to cell membranes.

Used In Evidence Reviews

A Pelargonium sidoides per Acute Bronchitis

EPs 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells.

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Study Design

Abstract

TL;DR

Used In Evidence Reviews

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