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Figure 6. MLN4924 and MG132 inhibited glucose/glucose oxidase (G/GO)−induced cell death, DNA fragmentation, and apoptosis. The cells were incubated with 5 nM MLN4924 or 0.5 µM MG132 for 1 h, then stimulated with G/GO for 16 h. (A) Viable cell counts were
Figure 20. Figure 6. MLN4924 and MG132 inhibited glucose/glucose oxidase (G/GO)−induced cell death, DNA fragmentation, and apoptosis. The cells were incubated with 5 nM MLN4924 or 0.5 µM MG132 for 1 h, then stimulated with G/GO for 16 h. (A) Viable cell counts were determined using the trypan blue exclusion test. (B) DNA fragmentation, expressed as an enrichment factor of untreated cells (AST and G/GO : cells without astaxanthin treatment, in the absence of G/GO) was set at 1. (C) Apoptosis was measured by flow cytometry using annexin V−fluorescein isothiocyanate (FITC)/propidium iodide (PI) staining. (D) A bar graph of FITC−labeled annexin V/PI staining is shown. Apoptotic cells were expressed as % of total cells ([apoptotic cell count]/[total observed cell count] × 100). All data are shown as mean ± standard error (SE) of three independent experiments. * p < 0.05 vs. untreated cells (AST− and G/GO−: cells without astaxanthin treatment in the absence of G/GO). + p < 0.05 vs. control cells (Inhibitor− and G/GO+: cells without MLN4924 or MG132 treatment in the presence of G/GO). MLN, MLN4924; MG, MG132.

설명

MLN4924 and MG132 inhibited glucose/glucose oxidase (G/GO)−induced cell death, DNA fragmentation, and apoptosis. The cells were incubated with 5 nM MLN4924 or 0.5 µM MG132 for 1 h, then stimulated with G/GO for 16 h.

More Figures from This Paper

Experimental results examining astaxanthin Inhibits Oxidative Stress, with data points illustrating key findings related to oxidative stress induces DNA damage which can be repaired by DNA repair proteins, such as Ku70/80.

Figure 6

Experimental results examining astaxanthin Inhibits Oxidative Stress, with data points illustrating key findings related to oxidative stress induces DNA damage which can be repaired by DNA repair proteins, such as Ku70/80.

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Statistical analysis from research investigating astaxanthin Inhibits Oxidative Stress, comparing treatment groups and control conditions.

Figure 7

Statistical analysis from research investigating astaxanthin Inhibits Oxidative Stress, comparing treatment groups and control conditions.

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Glucose/glucose oxidase (G/GO) treatment induced cell death, DNA fragmentation, and apoptosis in AGS cells. The cells were stimulated with G/GO for the indicated periods.

Figure 8

Glucose/glucose oxidase (G/GO) treatment induced cell death, DNA fragmentation, and apoptosis in AGS cells. The cells were stimulated with G/GO for the indicated periods.

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cells in G/GO-treated cells (Figure 2C,D). These data show that astaxanthin inhibits G/GOinduced cell death, DNA fragmentation, and apoptosis in AGS cells in a dose-dependent manner.

Figure 9

cells in G/GO-treated cells (Figure 2C,D). These data show that astaxanthin inhibits G/GOinduced cell death, DNA fragmentation, and apoptosis in AGS cells in a dose-dependent manner.

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Quantitative data from a study on astaxanthin Inhibits Oxidative Stress, presenting measured outcomes relevant to the investigation of oxidative stress induces DNA damage which can be repaired by DNA repair proteins, such as Ku70/80.

Figure 10

Quantitative data from a study on astaxanthin Inhibits Oxidative Stress, presenting measured outcomes relevant to the investigation of oxidative stress induces DNA damage which can be repaired by DNA repair proteins, such as Ku70/80.

chart
Experimental results examining astaxanthin Inhibits Oxidative Stress, with data points illustrating key findings related to oxidative stress induces DNA damage which can be repaired by DNA repair proteins, such as Ku70/80.

Figure 11

Experimental results examining astaxanthin Inhibits Oxidative Stress, with data points illustrating key findings related to oxidative stress induces DNA damage which can be repaired by DNA repair proteins, such as Ku70/80.

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Figure 20

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Source Paper

Astaxanthin Inhibits Oxidative Stress-Induced Ku Protein Degradation and Apoptosis in Gastric Epithelial Cells.

Nutrients (2022)

PMID: 36235593

DOI: 10.3390/nu14193939

Cite This Figure

![Figure 20: MLN4924 and MG132 inhibited glucose/glucose oxidase (G/GO)−induced cell death, DNA fragmentation, and apoptosis. The cells were incubated with 5 nM MLN4924 or 0.5 µM MG132 for 1 h, then stimulated with G/GO for 16 h.](https://pdfs.citedhealth.com/figures/36235593/245.png)

> Source: Jaeeun Lee et al. "Astaxanthin Inhibits Oxidative Stress-Induced Ku Protein Degradation and Apoptos." *Nutrients*, 2022. PMID: [36235593](https://pubmed.ncbi.nlm.nih.gov/36235593/)
<figure>
  <img src="https://pdfs.citedhealth.com/figures/36235593/245.png" alt="MLN4924 and MG132 inhibited glucose/glucose oxidase (G/GO)−induced cell death, DNA fragmentation, and apoptosis. The cells were incubated with 5 nM MLN4924 or 0.5 µM MG132 for 1 h, then stimulated with G/GO for 16 h." />
  <figcaption>Figure 20. MLN4924 and MG132 inhibited glucose/glucose oxidase (G/GO)−induced cell death, DNA fragmentation, and apoptosis. The cells were incubated with 5 nM MLN4924 or 0.5 µM MG132 for 1 h, then stimulated with G/GO for 16 h.<br>  Source: Jaeeun Lee et al. "Astaxanthin Inhibits Oxidative Stress-Induced Ku Protein Degradation and Apoptos." <em>Nutrients</em>, 2022. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/36235593/">36235593</a></figcaption>
</figure>

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Astaxanthin 관련 Oxidative Stress

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