Randomized Controlled Trials
Gold-standard experimental studies with random treatment allocation.
Synergic Efficacy of a Multicomponent Nutraceutical Add-On Therapy in Seasonal Allergic Rhinitis in Children: A Prospective, Randomized, Parallel-Group Study.
Journal of clinical medicine
2025
7 citations
Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial.
Frontiers in immunology
2025
2 citations
Cordyceps militaris extract and cordycepin ameliorate LPS-challenged colonic damage in piglets by modulating the microbiota and metabolite profiles.
Frontiers in immunology
2025
1 citation
Comparison of Safety and Efficacy of Topical Mometasone 0.1% Ointment, Calcipotriol 0.005% Ointment, and Tacrolimus 0.1% Ointment in Patients with Localized Alopecia Areata: A Triple-Arm Randomized Clinical Study.
Indian dermatology online journal
2025
1 citation
Effects of a Novel Dispersible Supplement Containing 2500 IU of Vitamin D and 1000 µg of B12 in Restoring Vitamin D and B12 Insufficiency: A Multicenter, Randomized Controlled Trial.
Nutrients
2025
Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and inflammation in type 2 diabetes.
Scientific reports
2025
Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.
Animals : an open access journal from MDPI
2025
Protective Effect of Methyl Sulfonyl Methane on the Progression of Age-Induced Bone Loss by Regulating Oxidative Stress-Mediated Bone Resorption.
Antioxidants (Basel, Switzerland)
2025
Vitamin D stimulates Il-15 synthesis in rodent muscle.
Biochemistry and biophysics reports
2025
Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus.
Cureus
2025
Efficacy and Safety of YJP-40 in Patients with Acute Bronchitis: A Randomized, Double-Blind, Parallel Group Study.
Tuberculosis and respiratory diseases
2025
Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial.
Arthritis & rheumatology (Hoboken, N.J.)
2024
25 citations
Astaxanthin supplementation impact on insulin resistance, lipid profile, blood pressure, and oxidative stress in polycystic ovary syndrome patients: A triple-blind randomized clinical trial.
Phytotherapy research : PTR
2024
24 citations
Impact of astaxanthin supplementation on markers of cardiometabolic health and tactical performance among firefighters.
Journal of the International Society of Sports Nutrition
2024
10 citations
Astaxanthin improves assisted reproductive technology outcomes in poor ovarian responders through alleviating oxidative stress, inflammation, and apoptosis: a randomized clinical trial.
Journal of ovarian research
2024
9 citations
Beet supplementation mitigates post-exercise inflammation.
Frontiers in nutrition
2024
8 citations
Sex differences in lipid mediators derived from omega-3 fatty acids in older individuals with low-grade chronic inflammation.
Prostaglandins, leukotrienes, and essential fatty acids
2024
6 citations
The anti-infective effect of β-glucans in children.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
2024
5 citations
Efficacy and safety of mixture of ivy leaf extract and coptidis rhizome in the treatment of acute bronchitis: multicenter, randomized, double-blinded, active-controlled, parallel, therapeutic confirmatory clinical trial.
Current medical research and opinion
2024
2 citations
Effect of Omega-3 Fatty Acid Supplementation on Periodontal Inflammation and Pocket Depth Reduction.
Journal of pharmacy & bioallied sciences
2024
1 citation
Intralesional vitamin D3 versus intralesional triamcinolone acetonoid in patchy alopecia areata: a comparative clinical and dermoscopic study.
Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
2024
1 citation
Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial-the DIETA trial.
Advances in rheumatology (London, England)
2024
Effects of Qiye Shen'an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune Function and Quality of Life in Patients with Chronic Fatigue Syndrome.
Alternative therapies in health and medicine
2024
Astaxanthin ameliorates inflammation, oxidative stress, and reproductive outcomes in endometriosis patients undergoing assisted reproduction: A randomized, triple-blind placebo-controlled clinical trial.
Frontiers in endocrinology
2023
44 citations
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), somatic and fatigue symptoms in cardiovascular diseases comorbid major depressive disorder (MDD): A randomized controlled trial.
Brain, behavior, and immunity
2023
18 citations
Differential effects of high dose omega-3 fatty acids on metabolism and inflammation in patients with obesity: eicosapentaenoic and docosahexaenoic acid supplementation.
Frontiers in nutrition
2023
17 citations
Safety of Pelargonium extract EPs 7630 in young children with acute bronchitis.
Frontiers in pediatrics
2023
7 citations
Efficacy and safety of AP-Bio®(KalmCold®) in participants with uncomplicated upper respiratory tract viral infection (common cold) - A phase III, double-blind, parallel group, randomized placebo-controlled trial.
Complementary therapies in medicine
2023
6 citations
Early Trends to Show the Efficacy of Cordyceps militaris in Mild to Moderate COVID Inflammation.
Cureus
2023
5 citations
Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion.
European review for medical and pharmacological sciences
2023
2 citations
Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial.
BMJ (Clinical research ed.)
2022
307 citations
Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial.
Complementary therapies in medicine
2022
115 citations
Effects of Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation on Biomarkers of Systemic Inflammation: 4-Year Findings from the VITAL Randomized Trial.
Nutrients
2022
29 citations
Intralesional vitamin D3 in treatment of alopecia areata: A randomized controlled clinical trial.
Journal of cosmetic dermatology
2022
23 citations
Antiallergic activities of shallot (Allium ascalonicum L.) and its therapeutic effects in allergic rhinitis.
Asian Pacific journal of allergy and immunology
2022
12 citations
Astaxanthin attenuates irradiation-induced osteoporosis in mice by inhibiting oxidative stress, osteocyte senescence, and SASP.
Food & function
2022
10 citations
Supplementation of Enriched Polyunsaturated Fatty Acids and CLA Cheese on High Fat Diet: Effects on Lipid Metabolism and Fat Profile.
Foods (Basel, Switzerland)
2022
9 citations
Metabolomics study of the effect of Danggui Buxue Tang on rats with chronic fatigue syndrome.
Biomedical chromatography : BMC
2022
9 citations
Single-Center-Single-Blinded Clinical Trial to Evaluate the Efficacy of a Nutraceutical Containing Boswellia Serrata, Bromelain, Zinc, Magnesium, Honey, Tyndallized Lactobacillus Acidophilus and Casei to Fight Upper Respiratory Tract Infection and Otitis Media.
Healthcare (Basel, Switzerland)
2022
7 citations
Zinc and L-Ascorbic Acid Dietary Supplementation Affected Antioxidant Status, Heat Shock Protein 70, and Some Immunoglobulins in Japanese Quail Under Heat Stress Conditions.
Biological trace element research
2022
5 citations
Supplementation With Spirulina platensis Improves Tracheal Reactivity in Wistar Rats by Modulating Inflammation and Oxidative Stress.
Frontiers in pharmacology
2022
5 citations
Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with men who binge drink alcohol.
Alcoholism, clinical and experimental research
2022
4 citations
The efficacy and safety of DW1601 in patients with acute bronchitis: a multi-center, randomized, double-blind, phase III clinical trial.
The Korean journal of internal medicine
2022
3 citations
β -Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency-A Randomized, Placebo-Controlled, and Double-Blinded Trial.
Chinese journal of integrative medicine
2022
2 citations
Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice.
British journal of pharmacology
2021
139 citations
Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid.
Clinical science (London, England : 1979)
2021
35 citations
Probiotics with vitamin C for the prevention of upper respiratory tract symptoms in children aged 3-10 years: randomised controlled trial.
Beneficial microbes
2021
18 citations
Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training.
Medicine and science in sports and exercise
2021
18 citations
Pelargonium sidoides root extract for the treatment of acute cough due to lower respiratory tract infection in adults: a feasibility double-blind, placebo-controlled randomised trial.
BMC complementary medicine and therapies
2021
16 citations
Effects of different types of zinc supplement on the growth, incidence of diarrhea, immune function, and rectal microbiota of newborn dairy calves.
Journal of dairy science
2020
58 citations
Beverage Containing Dispersible Yeast β-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled Trial.
Journal of dietary supplements
2020
27 citations
Soluble and Insoluble Yeast β-Glucan Differentially Affect Upper Respiratory Tract Infection in Marathon Runners: A Double-Blind, Randomized Placebo-Controlled Trial.
Journal of medicinal food
2020
24 citations
Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes.
Clinical and translational allergy
2020
20 citations
Elderberry Extract Outpatient Influenza Treatment for Emergency Room Patients Ages 5 and Above: a Randomized, Double-Blind, Placebo-Controlled Trial.
Journal of general internal medicine
2020
14 citations
Intake of 25-Hydroxyvitamin D3 May Reduce the Severity of Upper Respiratory Tract Infection: Post hoc Analysis of a Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study.
Nutrients
2020
1 citation
Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial.
Frontiers in immunology
2019
127 citations
Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, placebo controlled, randomised clinical trial.
Beneficial microbes
2019
82 citations
Pelargonium sidoides radix extract EPs 7630 reduces rhinovirus infection through modulation of viral binding proteins on human bronchial epithelial cells.
PloS one
2019
50 citations
Effects of Yeast (1,3)-(1,6)-Beta-Glucan on Severity of Upper Respiratory Tract Infections: A Double-Blind, Randomized, Placebo-Controlled Study in Healthy Subjects.
Journal of the American College of Nutrition
2019
47 citations
Effect of a Euglena gracilis Fermentate on Immune Function in Healthy, Active Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
Nutrients
2019
34 citations
A polycentric, randomized, parallel-group, study on Lertal®, a multicomponent nutraceutical, as preventive treatment in children with allergic rhinoconjunctivitis: phase II.
Italian journal of pediatrics
2019
26 citations
Treatment with EPs 7630, a Pelargonium Sidoides Root Extract, Is Effective and Safe in Patients with the Common Cold: Results From a Randomized, Double Blind, Placebo-Controlled Clinical Trial.
Integrative medicine (Encinitas, Calif.)
2019
17 citations
Effect of High-Dose Vitamin D Supplementation on Upper Respiratory Tract Infection Symptom Severity in Healthy Children.
The Pediatric infectious disease journal
2019
15 citations
Association of the 25(OH) vitamin D status with upper respiratory tract infections morbidity in water sports elite athletes.
The Journal of sports medicine and physical fitness
2019
9 citations
HATRIC: a study of Pelargonium sidoides root extract EPs®7630 (Kaloba®) for the treatment of acute cough due to lower respiratory tract infection in adults-study protocol for a double blind, placebo-controlled randomised feasibility trial.
Pilot and feasibility studies
2019
8 citations
The Effects of OMEGA-3 Fatty Acid Supplementation Upon Interleukin-12 and Interleukin-18 in Chronic Kidney Disease Patients.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
2019
7 citations
Infection Status of Rural Schoolchildren and its Relationship with Vitamin D Concentrations.
Indian journal of pediatrics
2019
3 citations
Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids.
Prostaglandins, leukotrienes, and essential fatty acids
2018
38 citations
Vitamin D₃ Supplementation Reduces the Symptoms of Upper Respiratory Tract Infection during Winter Training in Vitamin D-Insufficient Taekwondo Athletes: A Randomized Controlled Trial.
International journal of environmental research and public health
2018
37 citations
Can Curcumin Counteract Cognitive Decline? Clinical Trial Evidence and Rationale for Combining ω-3 Fatty Acids with Curcumin.
Advances in nutrition (Bethesda, Md.)
2018
28 citations
EPs 7630 is effective and safe in children under 6 years with acute respiratory tract infections: clinical studies revisited.
Current medical research and opinion
2018
28 citations
Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study.
The journal of nutrition, health & aging
2018
27 citations
Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis.
Thyroid : official journal of the American Thyroid Association
2017
170 citations
High-Dose Monthly Vitamin D for Prevention of Acute Respiratory Infection in Older Long-Term Care Residents: A Randomized Clinical Trial.
Journal of the American Geriatrics Society
2017
137 citations
Effect of High-Dose vs Standard-Dose Wintertime Vitamin D Supplementation on Viral Upper Respiratory Tract Infections in Young Healthy Children.
JAMA
2017
131 citations
Effects of combined low-dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non-invasive indices of steatosis and fibrosis, and adipokine levels in non-alcoholic fatty liver disease: a randomized controlled trial.
Diabetes, obesity & metabolism
2017
69 citations
Aging, low-grade systemic inflammation and vitamin D: a mini-review.
European journal of clinical nutrition
2017
66 citations
A Comparison of the Anti-Inflammatory Effects of Cis-9, Trans-11 Conjugated Linoleic Acid to Celecoxib in the Collagen-Induced Arthritis Model.
Lipids
2017
21 citations
Arginine Silicate Inositol Complex Accelerates Cutaneous Wound Healing.
Biological trace element research
2017
10 citations
Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial.
Nutrients
2016
98 citations
Vitamin D Supplementation and the Risk of Colds in Patients with Asthma.
American journal of respiratory and critical care medicine
2016
45 citations
Effects of zinc supplementation in the prevention of respiratory tract infections and diarrheal disease in Colombian children: A 12-month randomised controlled trial.
Allergologia et immunopathologia
2016
31 citations
The impact of sleeping with reduced glycogen stores on immunity and sleep in triathletes.
European journal of applied physiology
2016
A nutritional formula enriched with arginine, zinc, and antioxidants for the healing of pressure ulcers: a randomized trial.
Annals of internal medicine
2015
110 citations
Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study.
European journal of clinical nutrition
2015
70 citations
Omega 3 (n-3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with homozygous sickle cell disease.
Blood cells, molecules & diseases
2015
53 citations
Topical Calcipotriol Therapy for Mild-to-Moderate Alopecia Areata: A Retrospective Study.
Journal of drugs in dermatology : JDD
2015
50 citations
Antitussive effect of a fixed combination of Justicia adhatoda, Echinacea purpurea and Eleutherococcus senticosus extracts in patients with acute upper respiratory tract infection: A comparative, randomized, double-blind, placebo-controlled study.
Phytomedicine : international journal of phytotherapy and phytopharmacology
2015
36 citations
Vitamin D3 and gargling for the prevention of upper respiratory tract infections: a randomized controlled trial.
BMC infectious diseases
2014
58 citations
The effect of omega-3 fatty acids on depressive symptoms and inflammatory markers in maintenance hemodialysis patients: a randomized, placebo-controlled clinical trial.
European journal of clinical pharmacology
2014
Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise.
Journal of dietary supplements
2013
99 citations
Vitamin D3 supplementation and upper respiratory tract infections in a randomized, controlled trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2013
58 citations
Treatment of acute bronchitis with EPs 7630: randomized, controlled trial in children and adolescents.
Pediatrics international : official journal of the Japan Pediatric Society
2012
56 citations
Zinc combined with vitamin A reduces upper respiratory tract infection morbidity in a randomised trial in preschool children in Indonesia.
The British journal of nutrition
2012
40 citations
Consumption of gold kiwifruit reduces severity and duration of selected upper respiratory tract infection symptoms and increases plasma vitamin C concentration in healthy older adults.
The British journal of nutrition
2012
40 citations
Oleic acid attenuates trans-10,cis-12 conjugated linoleic acid-mediated inflammatory gene expression in human adipocytes.
Lipids
2012
28 citations
New actions for old nutrients.
Acta scientiarum polonorum. Technologia alimentaria
2012
11 citations
The in vivo infusion of hydrogen peroxide induces oxidative stress and differentially affects the activities of small intestinal carbohydrate digestive enzymes in the neonatal pig.
Journal of animal science
2012
8 citations
Ingestion of micronutrient fortified breakfast cereal has no influence on immune function in healthy children: a randomized controlled trial.
Nutrition journal
2011
12 citations
Zinc supplementation and TNF-α levels in vaccinated cardiac patients.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
2011
11 citations