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Inflammatory biomarker changes over 4 years in participants receiving marine omega-3 fatty acids versus placebo in the VITAL trial. The 2x2 factorial design enables independent assessment of omega-3 effects on systemic inflammation.

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![Figure 2: Inflammatory biomarker changes over 4 years in participants receiving marine omega-3 fatty acids versus placebo in the VITAL trial. The 2x2 factorial design enables independent assessment of omega-3 effects on systemic inflammation.]()

> Source: Yanbin Dong et al. "Effects of Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation on Biomarke." *Nutrients*, 2022. PMID: [36558465](https://pubmed.ncbi.nlm.nih.gov/36558465/)
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  <img src="" alt="Inflammatory biomarker changes over 4 years in participants receiving marine omega-3 fatty acids versus placebo in the VITAL trial. The 2x2 factorial design enables independent assessment of omega-3 effects on systemic inflammation." />
  <figcaption>Figure 2. Inflammatory biomarker changes over 4 years in participants receiving marine omega-3 fatty acids versus placebo in the VITAL trial. The 2x2 factorial design enables independent assessment of omega-3 effects on systemic inflammation.<br>  Source: Yanbin Dong et al. "Effects of Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation on Biomarke." <em>Nutrients</em>, 2022. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/36558465/">36558465</a></figcaption>
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