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Figure 1. Role of lysosomal dysfunction in the progression of cardiovascular disease (CVD). Lysosomal dysfunction, characterized by lysosomal membrane permeabilization and lipid accumulation, leads to the release of cathepsins and reactive oxygen species
Figure 1. Figure 1. Role of lysosomal dysfunction in the progression of cardiovascular disease (CVD). Lysosomal dysfunction, characterized by lysosomal membrane permeabilization and lipid accumulation, leads to the release of cathepsins and reactive oxygen species (ROS). These factors activate inflammasomes, promoting the cleavage of pro-IL-1β into its active form, IL-1β, which triggers chronic inflammation. In addition, oxidative stress exacerbates lysosomal damage [22]. These processes collectively drive cellular senescence and contribute to CVD progression. This figure highlights the interplay between lysosomal dysfunction, chronic inflammation, and oxidative stress in the pathogenesis of CVD.

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Source Paper

Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovascular Drugs and Future Directions.

Biomedicines (2025)

PMID: 40426881

DOI: 10.3390/biomedicines13051053

Cite This Figure

![Figure 1: Figure 1. Role of lysosomal dysfunction in the progression of cardiovascular disease (CVD). Lysosomal dysfunction, characterized by lysosomal membrane permeabilization and lipid accumulation, leads to the release of cathepsins and reactive oxygen species ](https://pdfs.citedhealth.com/figures/40426881/112.png)

> Source: Toshiki Otoda et al. "Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovasc." *Biomedicines*, 2025. PMID: [40426881](https://pubmed.ncbi.nlm.nih.gov/40426881/)
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  <img src="https://pdfs.citedhealth.com/figures/40426881/112.png" alt="Figure 1. Role of lysosomal dysfunction in the progression of cardiovascular disease (CVD). Lysosomal dysfunction, characterized by lysosomal membrane permeabilization and lipid accumulation, leads to the release of cathepsins and reactive oxygen species " />
  <figcaption>Figure 1. Figure 1. Role of lysosomal dysfunction in the progression of cardiovascular disease (CVD). Lysosomal dysfunction, characterized by lysosomal membrane permeabilization and lipid accumulation, leads to the release of cathepsins and reactive oxygen species <br>  Source: Toshiki Otoda et al. "Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovasc." <em>Biomedicines</em>, 2025. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/40426881/">40426881</a></figcaption>
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