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Figure 2. Change of the microbiome (e.g., by Western diet) resulting in intestinal dysbiosis leads to low grade inflammation in the gut and to increased intestinal and BBB permeability and consecutively to neuroinflammation and cognitive decline; oral patho
Figure 7. Figure 2. Change of the microbiome (e.g., by Western diet) resulting in intestinal dysbiosis leads to low grade inflammation in the gut and to increased intestinal and BBB permeability and consecutively to neuroinflammation and cognitive decline; oral pathobionts like P. gingivalis lead to oralisation of gut microbiota on the one hand, thus additionally driving gut inflammation and on the other hand promoting neuroinflammatory processes by translocation of bacteria to the brain via toxic proteases. Abbreviations: IL = interleukin, TNF = tumor necrosis factor; BBB = blood brain barrier.

Mô tả

Western diet-induced microbiome changes are mapped to intestinal dysbiosis, low-grade gut inflammation, and increased permeability of both the intestinal barrier and blood-brain barrier. The resulting systemic inflammatory state is linked to neuroinflammatory processes implicated in Alzheimer's disease progression.

More Figures from This Paper

A pathway diagram illustrates how gut dysbiosis promotes intestinal and systemic inflammation, leading to amyloid-beta aggregation, neuroinflammation, and ultimately neurodegeneration in Alzheimer's disease. The cascade connects microbial imbalance to blood-brain barrier compromise and central nervous system pathology.

Figure 6

A pathway diagram illustrates how gut dysbiosis promotes intestinal and systemic inflammation, leading to amyloid-beta aggregation, neuroinflammation, and ultimately neurodegeneration in Alzheimer's disease. The cascade connects microbial imbalance to blood-brain barrier compromise and central nervous system pathology.

diagram

Figure 7

Diagram
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Source Paper

The Immunopathogenesis of Alzheimer's Disease Is Related to the Composition of Gut Microbiota.

Nutrients (2021)

PMID: 33504065

DOI: 10.3390/nu13020361

Cite This Figure

![Figure 7: Western diet-induced microbiome changes are mapped to intestinal dysbiosis, low-grade gut inflammation, and increased permeability of both the intestinal barrier and blood-brain barrier. The resulting systemic inflammatory state is linked to neuroinflammatory processes implicated in Alzheimer's disease progression.](https://pdfs.citedhealth.com/figures/33504065/157.png)

> Source: Friedrich Leblhuber et al. "The Immunopathogenesis of Alzheimer's Disease Is Related to the Composition of G." *Nutrients*, 2021. PMID: [33504065](https://pubmed.ncbi.nlm.nih.gov/33504065/)
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  <img src="https://pdfs.citedhealth.com/figures/33504065/157.png" alt="Western diet-induced microbiome changes are mapped to intestinal dysbiosis, low-grade gut inflammation, and increased permeability of both the intestinal barrier and blood-brain barrier. The resulting systemic inflammatory state is linked to neuroinflammatory processes implicated in Alzheimer's disease progression." />
  <figcaption>Figure 7. Western diet-induced microbiome changes are mapped to intestinal dysbiosis, low-grade gut inflammation, and increased permeability of both the intestinal barrier and blood-brain barrier. The resulting systemic inflammatory state is linked to neuroinflammatory processes implicated in Alzheimer's disease progression.<br>  Source: Friedrich Leblhuber et al. "The Immunopathogenesis of Alzheimer's Disease Is Related to the Composition of G." <em>Nutrients</em>, 2021. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/33504065/">33504065</a></figcaption>
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