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Figure 2. The role of osteopontin in regulating cell survival and cell death pathways. OPN: osteopontin; PI3K/Akt: phosphatidylinositol 3-kinase/protein kinase B; MAPK: mitogen-activated protein kinase; ERK: extracellular signal-regulated kinase; JNK: c-J
Figure 67. Figure 2. The role of osteopontin in regulating cell survival and cell death pathways. OPN: osteopontin; PI3K/Akt: phosphatidylinositol 3-kinase/protein kinase B; MAPK: mitogen-activated protein kinase; ERK: extracellular signal-regulated kinase; JNK: c-Jun N-terminal kinase; NLRP3: NOD-like receptor family pyrin domain-containing 3; GSDMD: Gasdermin D; ER: Endoplasmic Reticulum; ATF4: Activating transcription factor 4; Fas: Fas cell surface death receptor; FasL: Fas ligand; TNFR: Tumor necrosis factor receptor; TNF-α: Tumor necrosis factor alpha; TRAIL: TNF-related apoptosis-inducing ligand; p53: Tumor protein p53; Caspase-1: Cysteine-aspartic protease 1.

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Source Paper

Osteopontin in Chronic Inflammatory Diseases: Mechanisms, Biomarker Potential, and Therapeutic Strategies.

Biology (2025)

PMID: 40282293

DOI: 10.3390/biology14040428

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![Figure 67: Figure 2. The role of osteopontin in regulating cell survival and cell death pathways. OPN: osteopontin; PI3K/Akt: phosphatidylinositol 3-kinase/protein kinase B; MAPK: mitogen-activated protein kinase; ERK: extracellular signal-regulated kinase; JNK: c-J](https://pdfs.citedhealth.com/figures/40282293/333.png)

> Source: Fuyuan Lang et al. "Osteopontin in Chronic Inflammatory Diseases: Mechanisms, Biomarker Potential, a." *Biology*, 2025. PMID: [40282293](https://pubmed.ncbi.nlm.nih.gov/40282293/)
<figure>
  <img src="https://pdfs.citedhealth.com/figures/40282293/333.png" alt="Figure 2. The role of osteopontin in regulating cell survival and cell death pathways. OPN: osteopontin; PI3K/Akt: phosphatidylinositol 3-kinase/protein kinase B; MAPK: mitogen-activated protein kinase; ERK: extracellular signal-regulated kinase; JNK: c-J" />
  <figcaption>Figure 67. Figure 2. The role of osteopontin in regulating cell survival and cell death pathways. OPN: osteopontin; PI3K/Akt: phosphatidylinositol 3-kinase/protein kinase B; MAPK: mitogen-activated protein kinase; ERK: extracellular signal-regulated kinase; JNK: c-J<br>  Source: Fuyuan Lang et al. "Osteopontin in Chronic Inflammatory Diseases: Mechanisms, Biomarker Potential, a." <em>Biology</em>, 2025. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/40282293/">40282293</a></figcaption>
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