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Figure 4. The Keap1-NRF2 pathway. Under normal conditions, Keap1 behaves as a negative regulator of NRF2, preventing its activation and thereby inhibiting its antioxidant response. Keap1 binds to
Figure 6. Figure 4. The Keap1-NRF2 pathway. Under normal conditions, Keap1 behaves as a negative regulator of NRF2, preventing its activation and thereby inhibiting its antioxidant response. Keap1 binds to

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The Keap1-NRF2 pathway. Under normal conditions, Keap1 behaves as a negative regulator of NRF2, preventing its activation and thereby inhibiting its antioxidant response.

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![Figure 6: The Keap1-NRF2 pathway. Under normal conditions, Keap1 behaves as a negative regulator of NRF2, preventing its activation and thereby inhibiting its antioxidant response.](https://pdfs.citedhealth.com/figures/40362738/170.png)

> Source: Miriam Cerullo et al. "Curcumin Modulation of the Gut-Brain Axis for Neuroinflammation and Metabolic Di." *Nutrients*, 2025. PMID: [40362738](https://pubmed.ncbi.nlm.nih.gov/40362738/)
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  <img src="https://pdfs.citedhealth.com/figures/40362738/170.png" alt="The Keap1-NRF2 pathway. Under normal conditions, Keap1 behaves as a negative regulator of NRF2, preventing its activation and thereby inhibiting its antioxidant response." />
  <figcaption>Figure 6. The Keap1-NRF2 pathway. Under normal conditions, Keap1 behaves as a negative regulator of NRF2, preventing its activation and thereby inhibiting its antioxidant response.<br>  Source: Miriam Cerullo et al. "Curcumin Modulation of the Gut-Brain Axis for Neuroinflammation and Metabolic Di." <em>Nutrients</em>, 2025. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/40362738/">40362738</a></figcaption>
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