Hình ảnh Andrographis

Fig. 1 Andrographolide protected mice from radiation-induced lung injury. Mice were exposed to 18 Gy irradiation and then treated with the indicated doses of Andrographolide for 4 weeks after irradiation. a Representative images of mice at 8 weeks post-ir

Figure 2 Photograph

Mice exposed to 18 Gy irradiation and treated with varying doses of andrographolide for 4 weeks showed dose-dependent protection from radiation-induced lung injury. Representative images and quantitative data indicate that andrographolide significantly attenuated lung tissue damage.

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced …

Figure 3 Micrograph

Histological analysis of lung tissue from irradiated mice reveals the extent of inflammatory cell infiltration and fibrosis. Andrographolide treatment appears to reduce these pathological changes in a dose-dependent manner.

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced …

Figure 4 Chart

Inflammatory cytokine levels in lung tissue were measured following radiation exposure and andrographolide treatment. The data suggest that andrographolide suppresses pro-inflammatory mediator release in irradiated lung tissue.

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced …

Figure 5 Chart

AIM2 inflammasome activation and caspase-1-mediated pyroptosis play key roles in radiation-induced lung inflammation. This figure presents protein expression data showing andrographolide's inhibitory effects on the AIM2 inflammasome pathway.

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced …

Figure 6 Chart

Gasdermin D cleavage is a downstream event in pyroptotic cell death triggered by radiation. Western blot analysis demonstrates that andrographolide reduces Gasdermin D processing in macrophages exposed to radiation.

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced …

Figure 7 Chart

Immunofluorescence or protein analysis reveals that andrographolide prevents AIM2 from binding cytoplasmic DNA and forming active inflammasome complexes. These findings indicate a specific molecular target for andrographolide's protective mechanism.

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced …

Fig. 7 A graphic illustration of the mechanism of Andrographolide ameliorating radiation-induced lung injury. Andrographolide inhibits Caspase-1-mediated Gasdermin D-dependent pyroptosis in macrophage by preventing AIM2 from translocating into nucleus to

Figure 8 Diagram

Andrographolide ameliorates radiation-induced lung injury by inhibiting Caspase-1-mediated Gasdermin D-dependent pyroptosis in macrophages. This schematic illustrates how the compound prevents AIM2 from translocating into the nucleus, thereby blocking inflammasome assembly and downstream inflammatory cascades.

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced …

Figure 1 Chart

Experimental results examining early intervention with Kan Jang® to treat upper, with data points illustrating key findings related to BACKGROUND AND AIM: Andrographis paniculata and Eleutherococcus senticosus preparations and their fixed combination, .