Figure 2

Mice exposed to 18 Gy irradiation and treated with varying doses of andrographolide for 4 weeks showed dose-dependent protection from radiation-induced lung injury. Representative images and quantitative data indicate that andrographolide significantly attenuated lung tissue damage.

Figure 4

Inflammatory cytokine levels in lung tissue were measured following radiation exposure and andrographolide treatment. The data suggest that andrographolide suppresses pro-inflammatory mediator release in irradiated lung tissue.

Figure 5

AIM2 inflammasome activation and caspase-1-mediated pyroptosis play key roles in radiation-induced lung inflammation. This figure presents protein expression data showing andrographolide's inhibitory effects on the AIM2 inflammasome pathway.

Figure 6

Gasdermin D cleavage is a downstream event in pyroptotic cell death triggered by radiation. Western blot analysis demonstrates that andrographolide reduces Gasdermin D processing in macrophages exposed to radiation.

Figure 7

Immunofluorescence or protein analysis reveals that andrographolide prevents AIM2 from binding cytoplasmic DNA and forming active inflammasome complexes. These findings indicate a specific molecular target for andrographolide's protective mechanism.

Figure 8

Andrographolide ameliorates radiation-induced lung injury by inhibiting Caspase-1-mediated Gasdermin D-dependent pyroptosis in macrophages. This schematic illustrates how the compound prevents AIM2 from translocating into the nucleus, thereby blocking inflammasome assembly and downstream inflammatory cascades.