الوصف

MAPK signaling pathway activation by VEGF is attenuated by curcumin in a time- and dose-dependent manner. Phosphorylation of ERK, p38, and JNK is markedly reduced in curcumin-treated endothelial cells.

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Figure 5

COX-2 protein expression is upregulated by VEGF stimulation in intestinal endothelial cells, and curcumin effectively blocks this induction. Prostaglandin E2 production follows a similar pattern of inhibition.

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Figure 6

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Source Paper

Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition.

Gut (2008)

PMID: 18596194

DOI: 10.1136/gut.2008.152496

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![Figure 6: MAPK signaling pathway activation by VEGF is attenuated by curcumin in a time- and dose-dependent manner. Phosphorylation of ERK, p38, and JNK is markedly reduced in curcumin-treated endothelial cells.](https://pdfs.citedhealth.com/figures/18596194/243.png)

> Source: D G Binion et al. "Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular e." *Gut*, 2008. PMID: [18596194](https://pubmed.ncbi.nlm.nih.gov/18596194/)

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  <img src="https://pdfs.citedhealth.com/figures/18596194/243.png" alt="MAPK signaling pathway activation by VEGF is attenuated by curcumin in a time- and dose-dependent manner. Phosphorylation of ERK, p38, and JNK is markedly reduced in curcumin-treated endothelial cells." />
  <figcaption>Figure 6. MAPK signaling pathway activation by VEGF is attenuated by curcumin in a time- and dose-dependent manner. Phosphorylation of ERK, p38, and JNK is markedly reduced in curcumin-treated endothelial cells.<br>  Source: D G Binion et al. "Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular e." <em>Gut</em>, 2008. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/18596194/">18596194</a></figcaption>
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