Curcumin لـ Chronic Inflammation
AAn umbrella meta-analysis of 10 studies with 5,870 participants demonstrates curcumin supplementation may significantly reduce CRP, IL-6, and TNF-alpha inflammatory markers. Piperine co-administration increases bioavailability by approximately 2,000%.
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A
الخلاصة
An umbrella meta-analysis of 10 studies with 5,870 participants demonstrates curcumin supplementation may significantly reduce CRP, IL-6, and TNF-alpha inflammatory markers. Piperine co-administration increases bioavailability by approximately 2,000%.
Key Study Findings
Review
Therapeutic potential of curcumin against pancreatitis.
Dose: None
مقابل: None
Outcome: curcumin effects on pancreatitis via anti-inflammatory and antioxidant …
التأثير: None
None
المجتمع المدروس: None
Review
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: review of dietary polyphenols in type 2 diabetes mellitus management
Review
Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: review of plant-derived anti-inflammatory compounds for chronic disease prevention
Review
Pathological interplay of NF-κB and M1 macrophages in chronic inflammatory lung diseases.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: review of NF-kB and M1 macrophages in asthma, COPD, and pulmonary fibrosis
Review
Modulating Ferroptosis in Aging: The Therapeutic Potential of Natural Products.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
Review
Curcumin Modulation of the Gut-Brain Axis for Neuroinflammation and Metabolic Disorders Prevention and Treatment.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
Key Statistics
10
الدراسات
5870
المشاركون
↑
Positive
A
التقييم
Referenced Papers
Arab journal of …
2026
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Review
Nutrients
2025
32 اقتباسات
International journal of …
2025
32 اقتباسات
Pathology, research and …
2025
26 اقتباسات
Immunity & ageing …
2025
25 اقتباسات
Journal of aging …
2025
10 اقتباسات
Nutrients
2025
10 اقتباسات
Nutrients
2025
10 اقتباسات
Biomedicines
2025
8 اقتباسات
Materials today. Bio
2025
8 اقتباسات
Antioxidants (Basel, Switzerland)
2025
8 اقتباسات
Biology
2025
7 اقتباسات
Inflammopharmacology
2025
6 اقتباسات
International journal of …
2025
5 اقتباسات
Current issues in …
2025
5 اقتباسات
Cells
2025
4 اقتباسات
PNAS nexus
2025
2 اقتباسات
International journal of …
2025
2 اقتباسات
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Systematic Review
Frontiers in immunology
2025
1 اقتباسات
Journal of clinical …
2024
29 اقتباسات
Scientific reports
2024
18 اقتباسات
Iranian journal of …
2024
4 اقتباسات
Interventions for preventing the progression of autosomal dominant polycystic kidney disease.
Systematic Review
The Cochrane database …
2024
1 اقتباسات
Biomedicine & pharmacotherapy …
2023
115 اقتباسات
Current molecular pharmacology
2023
72 اقتباسات
International journal of …
2023
45 اقتباسات
Seminars in cancer …
2022
269 اقتباسات
Nutrition research (New …
2022
75 اقتباسات
Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation.
Review
Molecules (Basel, Switzerland)
2022
39 اقتباسات
Alternative therapies in …
2022
13 اقتباسات
Voprosy pitaniia
2022
1 اقتباسات
Biomedicines
2021
228 اقتباسات
The Journal of …
2021
117 اقتباسات
The Immunopathogenesis of Alzheimer's Disease Is Related to the Composition of Gut Microbiota.
Review
Nutrients
2021
117 اقتباسات
Nutrients
2021
36 اقتباسات
Osteoarthritis and cartilage
2021
21 اقتباسات
Frontiers in medicine
2021
13 اقتباسات
Frontiers in physiology
2021
12 اقتباسات
Advances in experimental …
2021
6 اقتباسات
European journal of …
2020
91 اقتباسات
Targeting gut barrier dysfunction with phytotherapies: Effective strategy against chronic diseases.
Review
Pharmacological research
2020
65 اقتباسات
Brain research bulletin
2020
58 اقتباسات
GeroScience
2020
31 اقتباسات
Molecular carcinogenesis
2020
4 اقتباسات
Journal of cellular …
2019
212 اقتباسات
International journal of …
2019
137 اقتباسات
Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases.
Review
European cardiology
2019
80 اقتباسات
Frontiers in endocrinology
2019
25 اقتباسات
Frontiers in immunology
2018
200 اقتباسات
Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy.
Review
Pharmacological research
2018
107 اقتباسات
Tissue barriers
2018
87 اقتباسات
Therapeutic Potential and Recent Advances of Curcumin in the Treatment of Aging-Associated Diseases.
Review
Molecules (Basel, Switzerland)
2018
87 اقتباسات
GeroScience
2018
80 اقتباسات
Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis.
Meta-Analysis
The American journal …
2018
30 اقتباسات
Advances in nutrition …
2018
28 اقتباسات
Current medicinal chemistry
2018
13 اقتباسات
Drug discovery today
2017
284 اقتباسات
Current pharmaceutical design
2017
168 اقتباسات
Science China. Life …
2017
49 اقتباسات
Journal of Alzheimer's …
2016
52 اقتباسات
Molecules (Basel, Switzerland)
2015
539 اقتباسات
CNS & neurological …
2014
68 اقتباسات
Journal of nutrigenetics …
2014
15 اقتباسات
BioFactors (Oxford, England)
2013
288 اقتباسات
Curcumin and obesity.
Review
BioFactors (Oxford, England)
2013
167 اقتباسات
Current pharmaceutical design
2012
54 اقتباسات
Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals.
Review
Nutrition reviews
2011
97 اقتباسات
Gut
2008
196 اقتباسات
Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.
Review
Molecular nutrition & …
2008
56 اقتباسات
Current drug targets
2006
92 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 500-1,000 mg/day curcuminoids
- enhancedabsorption:
- 150-500 mg/day (phytosome or piperine formulation)
الحد الأعلى: No established UL; generally well-tolerated up to 8 g/day
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
أفضل وقت للتناول: With meals containing fat and black pepper (piperine) for enhanced absorption
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Gastrointestinal discomfort (nausea, diarrhea, bloating)
- ⚠ Headache
- ⚠ Yellow stool discoloration
- ⚠ Iron absorption interference at very high doses
التفاعلات المعروفة
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk)
- ● Diabetes medications (may enhance blood sugar lowering)
- ● CYP1A2, CYP3A4, CYP2D6 substrates (may inhibit metabolism)
- ● Sulfasalazine and cyclophosphamide (may modify effects)
الحد الأقصى المسموح به: No established UL; generally well-tolerated up to 8 g/day
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Curcumin help with Chronic Inflammation?
Based on 10 studies with 5,870 participants, there is strong evidence from multiple clinical trials that Curcumin may support Chronic Inflammation management. Our evidence grade is A (Strong Evidence).
How much Curcumin should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day curcuminoids. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Headache, Yellow stool discoloration, Iron absorption interference at very high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Chronic Inflammation?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 10 peer-reviewed studies with 5,870 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Chronic Inflammation
إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.