What is the recommended dosage for Reishi Mushroom?

General: 1.5-9 g dried mushroom or 1-1.5 g extract/day; Immune Support: 1,000-3,000 mg extract/day

What are the side effects of Reishi Mushroom?

Potential side effects include: Gastrointestinal upset (dryness of mouth and throat, nausea), Dizziness, Nosebleeds (antiplatelet effect), Hepatotoxicity (rare, with powdered forms).

What is reishi and how does it support immune function?

Reishi (Ganoderma lucidum) is a medicinal mushroom used for centuries in East Asian medicine. Its beta-glucans and triterpenes have been studied for their potential to enhance natural killer cell activity, modulate cytokine production, and support overall immune surveillance.

What dosage of reishi has been used in clinical studies?

Clinical trials have used reishi extract at doses of 1.5–5.4 g per day of extract, or up to 9 g per day of dried mushroom powder. Standardized extracts containing 10–30% polysaccharides are most commonly used in research.

What are the potential side effects of reishi?

Side effects may include dry mouth, throat irritation, gastrointestinal discomfort, and dizziness. Reishi may interact with anticoagulant, antihypertensive, and immunosuppressant medications. Rare cases of liver toxicity have been reported with powdered preparations.

Reishi Mushroom

mushroom

Also known as: Ganoderma lucidum, Lingzhi, Mushroom of Immortality

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About

Reishi (Ganoderma lucidum) contains beta-glucans that bind to pattern recognition receptors (Dectin-1, CR3) on macrophages and dendritic cells, activating innate immune cascades. Its triterpenes modulate NF-kB signaling and cytokine production, and it enhances NK cell cytotoxicity. Over 400 bioactive compounds have been identified.

How It Works

Beta-glucans bind to pattern recognition receptors (Dectin-1, CR3) on macrophages and dendritic cells, activating innate immune cascades; triterpenes modulate NF-kB signaling and cytokine production; enhances NK cell cytotoxicity.

Evidence For Conditions

Condition	Grade	Studies	Participants
Immune Aging (Immunosenescence)	C	5	300	View →

Side Effects

Gastrointestinal upset (dryness of mouth and throat, nausea)
Dizziness
Nosebleeds (antiplatelet effect)
Hepatotoxicity (rare, with powdered forms)

Drug & Supplement Interactions

Anticoagulants and antiplatelet drugs (may increase bleeding risk)
Antihypertensive medications (additive blood pressure lowering)
Immunosuppressant medications (may counteract immunosuppression)
Diabetes medications (may lower blood sugar)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Chaga Mushroom Cordyceps Maitake Mushroom Turkey Tail Mushroom

Quick Facts

Dosage: General: 1.5-9 g dried mushroom or 1-1.5 g extract/day; Immune_Support: 1,000-3,000 mg extract/day
Forms: capsule powder extract tea tincture
Natural Sources: Wild-grown or cultivated Ganoderma lucidum fruiting body
Upper Limit: No established UL
Best Time: Can be taken any time; traditionally with warm water

Evidence Summary

Immune Aging (Immunosenescence) C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.