Curcumin 用于 Chronic Inflammation
AAn umbrella meta-analysis of 10 studies with 5,870 participants demonstrates curcumin supplementation may significantly reduce CRP, IL-6, and TNF-alpha inflammatory markers. Piperine co-administration increases bioavailability by approximately 2,000%.
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A
结论
An umbrella meta-analysis of 10 studies with 5,870 participants demonstrates curcumin supplementation may significantly reduce CRP, IL-6, and TNF-alpha inflammatory markers. Piperine co-administration increases bioavailability by approximately 2,000%.
Key Study Findings
Review
Therapeutic potential of curcumin against pancreatitis.
Dose: None
vs: None
Outcome: curcumin effects on pancreatitis via anti-inflammatory and antioxidant …
效果: None
None
研究人群: None
Review
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: review of dietary polyphenols in type 2 diabetes mellitus management
Review
Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: review of plant-derived anti-inflammatory compounds for chronic disease prevention
Review
Pathological interplay of NF-κB and M1 macrophages in chronic inflammatory lung diseases.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: review of NF-kB and M1 macrophages in asthma, COPD, and pulmonary fibrosis
Review
Modulating Ferroptosis in Aging: The Therapeutic Potential of Natural Products.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Review
Curcumin Modulation of the Gut-Brain Axis for Neuroinflammation and Metabolic Disorders Prevention and Treatment.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Key Statistics
10
研究数量
5870
受试者
↑
Positive
A
等级
Referenced Papers
Arab journal of …
2026
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Review
Nutrients
2025
32 次引用
International journal of …
2025
32 次引用
Pathology, research and …
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26 次引用
Immunity & ageing …
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Journal of aging …
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10 次引用
Nutrients
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10 次引用
Nutrients
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10 次引用
Biomedicines
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8 次引用
Materials today. Bio
2025
8 次引用
Antioxidants (Basel, Switzerland)
2025
8 次引用
Biology
2025
7 次引用
Inflammopharmacology
2025
6 次引用
International journal of …
2025
5 次引用
Current issues in …
2025
5 次引用
Cells
2025
4 次引用
PNAS nexus
2025
2 次引用
International journal of …
2025
2 次引用
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Systematic Review
Frontiers in immunology
2025
1 次引用
Journal of clinical …
2024
29 次引用
Scientific reports
2024
18 次引用
Iranian journal of …
2024
4 次引用
Interventions for preventing the progression of autosomal dominant polycystic kidney disease.
Systematic Review
The Cochrane database …
2024
1 次引用
Biomedicine & pharmacotherapy …
2023
115 次引用
Current molecular pharmacology
2023
72 次引用
International journal of …
2023
45 次引用
Seminars in cancer …
2022
269 次引用
Nutrition research (New …
2022
75 次引用
Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation.
Review
Molecules (Basel, Switzerland)
2022
39 次引用
Alternative therapies in …
2022
13 次引用
Voprosy pitaniia
2022
1 次引用
Biomedicines
2021
228 次引用
The Journal of …
2021
117 次引用
The Immunopathogenesis of Alzheimer's Disease Is Related to the Composition of Gut Microbiota.
Review
Nutrients
2021
117 次引用
Nutrients
2021
36 次引用
Osteoarthritis and cartilage
2021
21 次引用
Frontiers in medicine
2021
13 次引用
Frontiers in physiology
2021
12 次引用
Advances in experimental …
2021
6 次引用
European journal of …
2020
91 次引用
Targeting gut barrier dysfunction with phytotherapies: Effective strategy against chronic diseases.
Review
Pharmacological research
2020
65 次引用
Brain research bulletin
2020
58 次引用
GeroScience
2020
31 次引用
Molecular carcinogenesis
2020
4 次引用
Journal of cellular …
2019
212 次引用
International journal of …
2019
137 次引用
Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases.
Review
European cardiology
2019
80 次引用
Frontiers in endocrinology
2019
25 次引用
Frontiers in immunology
2018
200 次引用
Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy.
Review
Pharmacological research
2018
107 次引用
Tissue barriers
2018
87 次引用
Therapeutic Potential and Recent Advances of Curcumin in the Treatment of Aging-Associated Diseases.
Review
Molecules (Basel, Switzerland)
2018
87 次引用
GeroScience
2018
80 次引用
Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis.
Meta-Analysis
The American journal …
2018
30 次引用
Advances in nutrition …
2018
28 次引用
Current medicinal chemistry
2018
13 次引用
Drug discovery today
2017
284 次引用
Current pharmaceutical design
2017
168 次引用
Science China. Life …
2017
49 次引用
Journal of Alzheimer's …
2016
52 次引用
Molecules (Basel, Switzerland)
2015
539 次引用
CNS & neurological …
2014
68 次引用
Journal of nutrigenetics …
2014
15 次引用
BioFactors (Oxford, England)
2013
288 次引用
Curcumin and obesity.
Review
BioFactors (Oxford, England)
2013
167 次引用
Current pharmaceutical design
2012
54 次引用
Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals.
Review
Nutrition reviews
2011
97 次引用
Gut
2008
196 次引用
Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.
Review
Molecular nutrition & …
2008
56 次引用
Current drug targets
2006
92 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 500-1,000 mg/day curcuminoids
- enhancedabsorption:
- 150-500 mg/day (phytosome or piperine formulation)
上限： No established UL; generally well-tolerated up to 8 g/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
最佳服用时间： With meals containing fat and black pepper (piperine) for enhanced absorption
Safety & Side Effects
已报告的副作用
- ⚠ Gastrointestinal discomfort (nausea, diarrhea, bloating)
- ⚠ Headache
- ⚠ Yellow stool discoloration
- ⚠ Iron absorption interference at very high doses
已知相互作用
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk)
- ● Diabetes medications (may enhance blood sugar lowering)
- ● CYP1A2, CYP3A4, CYP2D6 substrates (may inhibit metabolism)
- ● Sulfasalazine and cyclophosphamide (may modify effects)
可耐受最高摄入量： No established UL; generally well-tolerated up to 8 g/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Curcumin help with Chronic Inflammation?
Based on 10 studies with 5,870 participants, there is strong evidence from multiple clinical trials that Curcumin may support Chronic Inflammation management. Our evidence grade is A (Strong Evidence).
How much Curcumin should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day curcuminoids. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Headache, Yellow stool discoloration, Iron absorption interference at very high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Chronic Inflammation?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 10 peer-reviewed studies with 5,870 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 Chronic Inflammation
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