Omega-3 Fatty Acids (EPA/DHA) 用于 Chronic Inflammation

The VITAL trial and multiple randomized controlled trials demonstrate omega-3 fatty acids may help reduce CRP and modulate inflammatory cytokines. DHA showed stronger anti-inflammatory effects than EPA, lowering 4 pro-inflammatory proteins versus 1 in a randomized study.

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结论

Key Study Findings

Review

Specialized pro-resolving mediators and autoimmunity: Recent insights and future perspectives.

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Review

Proresolving Lipid Mediators in the Respiratory System.

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Other

The omega effect: Harnessing fish oil for health.

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Review

Medical Nutrition Therapy in Dermatological Diseases: A Joint Consensus Statement of the Italian Association of …

Dose: None vs: None Outcome: None 效果: None None

研究人群: Patients with acne, HS, or psoriasis

Systematic Review

Impact of Vegan and Vegetarian Diets on Neurological Health: A Critical Review.

Dose: None vs: None Outcome: Neurological health outcomes 效果: None None

研究人群: None

Review

Immunomodulatory Effects of Omega-3 Fatty Acids: Mechanistic Insights and Health Implications.

Dose: None vs: None Outcome: None 效果: None None

研究人群: review of omega-3 fatty acids' immunomodulatory effects

Key Statistics

研究数量

30000

受试者

↑

Positive

等级

Referenced Papers

Immunomodulatory Effects of Omega-3 Fatty Acids: Mechanistic Insights and Health Implications. Review

Molecular nutrition & … 2025 44 次引用

Impact of Vegan and Vegetarian Diets on Neurological Health: A Critical Review. Systematic Review

Nutrients 2025 22 次引用

Proresolving Lipid Mediators in the Respiratory System. Review

Annual review of … 2025 13 次引用

Specialized pro-resolving mediators and autoimmunity: Recent insights and future perspectives. Review

Autoimmunity reviews 2025 10 次引用

Employing Nutrition to Delay Aging: A Plant-Based Telomere-Friendly Dietary Revolution. Review

Nutrients 2025 6 次引用

Immunosenescence and inflammaging: Mechanisms and modulation through diet and lifestyle. Review

Frontiers in immunology 2025 5 次引用

Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with low-grade chronic inflammation. Other

Prostaglandins & other … 2025 3 次引用

Association of omega-3, omega-6 fatty acids intakes and omega-6: omega-3 ratio with the prevalence of suicidal ideation: mediating role of … Other

Lipids in health … 2025 3 次引用

Sarcopenia in the Aging Process: Pathophysiological Mechanisms, Clinical Implications, and Emerging Therapeutic Approaches. Review

International journal of … 2025 3 次引用

The Impact of Flavonoids and Omega-3 in Mitigating Frailty Syndrome to Improve Treatment Outcomes in Peripheral Artery Disease (PAD) Patients. Review

Nutrients 2025 2 次引用

The omega effect: Harnessing fish oil for health. Other

Atherosclerosis 2025

Medical Nutrition Therapy in Dermatological Diseases: A Joint Consensus Statement of the Italian Association of Dietetics and Clinical Nutrition (ADI), … Review

Current obesity reports 2025

The effects of ω-3 fatty acids on inflammatory and oxidative stress markers in patients with Type 2 diabetes mellitus: A … Meta-Analysis

Prostaglandins & other … 2024 7 次引用

Sex differences in lipid mediators derived from omega-3 fatty acids in older individuals with low-grade chronic inflammation. RCT

Prostaglandins, leukotrienes, and … 2024 6 次引用

Effect of Omega-3 Fatty Acid Supplementation on Periodontal Inflammation and Pocket Depth Reduction. Other

Journal of pharmacy … 2024 1 次引用

Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial-the DIETA trial. RCT

Advances in rheumatology … 2024

Modulation of inflammation and immunity by omega-3 fatty acids: a possible role for prevention and to halt disease progression in … Other

European review for … 2023 67 次引用

A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation. Review

Biochemistry and biophysics … 2023 66 次引用

Resolution medicine in cancer, infection, pain and inflammation: are we on track to address the next Pandemic? Review

Cancer metastasis reviews 2023 28 次引用

Omega-3 polyunsaturated fatty acids (n-3 PUFAs), somatic and fatigue symptoms in cardiovascular diseases comorbid major depressive disorder (MDD): A randomized … RCT

Brain, behavior, and … 2023 18 次引用

Differential effects of high dose omega-3 fatty acids on metabolism and inflammation in patients with obesity: eicosapentaenoic and docosahexaenoic acid … Other

Frontiers in nutrition 2023 17 次引用

Maresin1: A multifunctional regulator in inflammatory bone diseases. Review

International immunopharmacology 2023 8 次引用

Effects of Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation on Biomarkers of Systemic Inflammation: 4-Year Findings from the VITAL … RCT

Nutrients 2022 29 次引用

Resolution of inflammation: Intervention strategies and future applications. Other

Toxicology and applied … 2022 20 次引用

Effect of omega-3 fatty acids on the telomere length: A mini meta-analysis of clinical trials. Meta-Analysis

Biomolecular concepts 2022 18 次引用

Association Between Omega-3 Fatty Acid Levels and Aortic Valve Calcium (from the Multi-Ethnic Study of Atherosclerosis). Other

The American journal … 2022 1 次引用

Coronary microvascular dysfunction as a chronic inflammatory state: Is there a role for omega-3 fatty acid treatment? Review

American heart journal … 2022

Do Eicosapentaenoic Acid and Docosahexaenoic Acid Have the Potential to Compete against Each Other? Review

Nutrients 2020 50 次引用

Relationship between nutrition and reproduction. Review

Reproductive medicine and … 2020 11 次引用

Association between plasma phospholipid omega-3 polyunsaturated fatty acids and type 2 diabetes is sex dependent: The Hunter Community Study. Other

Clinical nutrition (Edinburgh, … 2020 10 次引用

Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis. Other

Toxicology mechanisms and … 2019 33 次引用

Effect of omega-3 fatty acid plus vitamin E Co-Supplementation on lipid profile: A systematic review and meta-analysis. Meta-Analysis

Diabetes & metabolic … 2019 28 次引用

The Effects of OMEGA-3 Fatty Acid Supplementation Upon Interleukin-12 and Interleukin-18 in Chronic Kidney Disease Patients. RCT

Journal of renal … 2019 7 次引用

Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids. RCT

Prostaglandins, leukotrienes, and … 2018 38 次引用

Impaired Resolution of Inflammation in Alzheimer's Disease: A Review. Review

Frontiers in immunology 2017 74 次引用

Omega-3 fatty acids, lipid rafts, and T cell signaling. Review

European journal of … 2016 102 次引用

Omega-3 fatty acids prevent early-life antibiotic exposure-induced gut microbiota dysbiosis and later-life obesity. Other

International journal of … 2016 56 次引用

The association of dietary intake and supplementation of specific polyunsaturated fatty acids with inflammation and functional capacity in chronic obstructive … Systematic Review

International journal of … 2016 20 次引用

Studying Muscle Protein Turnover in CKD. Other

Clinical journal of … 2016 4 次引用

Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases. Review

Allergology international : … 2015 205 次引用

Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome. Review

Prostaglandins & other … 2015 182 次引用

Omega 3 (n-3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with … RCT

Blood cells, molecules … 2015 53 次引用

Omega-3 fatty acids and inflammation: a perspective on the challenges of evaluating efficacy in clinical research. Review

Prostaglandins & other … 2015 35 次引用

Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-β Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. Review

Journal of Alzheimer's … 2015 8 次引用

The effect of omega-3 fatty acids on depressive symptoms and inflammatory markers in maintenance hemodialysis patients: a randomized, placebo-controlled clinical … RCT

European journal of … 2014

Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis. Review

Nutrition research (New … 2013 90 次引用

The role of omega-3 fatty acids contained in olive oil on chronic inflammation. Review

Acta medica Indonesiana 2011 37 次引用

Cod liver oil, young children, and upper respiratory tract infections. Review

Journal of the … 2010 11 次引用

Omega-3 fatty acids and inflammation. Review

Current atherosclerosis reports 2004 464 次引用

Prevention of strokes. Review

Current atherosclerosis reports 2001 2 次引用

Effects of calorie restriction and ω-3 dietary fat on aging in short-and long-lived rodents. Other

Age 1998 4 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 250-500 mg combined EPA/DHA/day
antiinflammatory:: 1,000-3,000 mg combined EPA/DHA/day

上限： 3,000 mg/day EPA+DHA (FDA-recognized as safe)

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Positive	--

最佳服用时间： With meals

Safety & Side Effects

已报告的副作用

⚠ Fishy aftertaste and burping
⚠ Gastrointestinal discomfort (nausea, diarrhea)
⚠ Increased bleeding risk at high doses
⚠ Potential LDL cholesterol increase at very high doses

已知相互作用

● Anticoagulants and antiplatelet drugs (may increase bleeding risk)
● Blood pressure medications (additive blood pressure lowering)
● Orlistat (may reduce omega-3 absorption)
● Cyclosporine (may modify immunosuppressive effects)

可耐受最高摄入量： 3,000 mg/day EPA+DHA (FDA-recognized as safe)

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Omega-3 Fatty Acids (EPA/DHA) help with Chronic Inflammation?

Based on 30 studies with 30,000 participants, there is strong evidence from multiple clinical trials that Omega-3 Fatty Acids (EPA/DHA) may support Chronic Inflammation management. Our evidence grade is A (Strong Evidence).

How much Omega-3 Fatty Acids (EPA/DHA) should I take for Chronic Inflammation?

Studies have used various dosages. A commonly studied range is 250-500 mg combined EPA/DHA/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Omega-3 Fatty Acids (EPA/DHA)?

Reported side effects may include Fishy aftertaste and burping, Gastrointestinal discomfort (nausea, diarrhea), Increased bleeding risk at high doses, Potential LDL cholesterol increase at very high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Omega-3 Fatty Acids (EPA/DHA) and Chronic Inflammation?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 30 peer-reviewed studies with 30,000 total participants. The overall direction of effect is positive.