Conjugated Linoleic Acid 用于 Chronic Inflammation
DAnimal studies show CLA may have immunomodulatory effects via PPAR-gamma activation. Human evidence for immune-specific outcomes is limited and inconsistent, with some studies showing no significant benefit.
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D
结论
Animal studies show CLA may have immunomodulatory effects via PPAR-gamma activation. Human evidence for immune-specific outcomes is limited and inconsistent, with some studies showing no significant benefit.
Key Study Findings
Review
A perspective on the chemical structures and molecular mechanisms of curcumin and its derivatives and …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Review of curcumin derivatives in cancer treatment
Review
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: review of dietary polyphenols in type 2 diabetes mellitus management
Review
Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects …
Dose: None
vs: None
Outcome: Musculoskeletal aging and cellular senescence
效果: None
None
研究人群: Aging adults with musculoskeletal decline (review)
Review
Retracted: Chronic Epipharyngitis Treated with Epipharyngeal Abrasion Therapy: Symptoms, Diagnosis, Pathogenesis, and Treatment Outcomes.
Dose: 1% zinc chloride solution
vs: None
Outcome: Chronic epipharyngitis symptom improvement
效果: None
None
研究人群: Patients with chronic epipharyngitis (retracted publication)
Systematic Review
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Review of TCM compounds in autoimmune skin diseases
Other
The omega effect: Harnessing fish oil for health.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Key Statistics
3
研究数量
150
受试者
↔
Mixed
D
等级
Referenced Papers
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Review
Nutrients
2025
32 次引用
International journal of …
2025
5 次引用
International journal of …
2025
2 次引用
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Systematic Review
Frontiers in immunology
2025
1 次引用
Atherosclerosis
2025
JMA journal
2025
Journal of clinical …
2024
29 次引用
Molecular nutrition & …
2024
15 次引用
Newborn (Clarksville, Md.)
2024
9 次引用
Nutrients
2024
7 次引用
Advances in rheumatology …
2024
Current molecular pharmacology
2023
72 次引用
Immunological investigations
2023
13 次引用
International immunopharmacology
2023
8 次引用
International journal of …
2022
26 次引用
Effect of omega-3 fatty acids on the telomere length: A mini meta-analysis of clinical trials.
Meta-Analysis
Biomolecular concepts
2022
18 次引用
Foods (Basel, Switzerland)
2022
9 次引用
Nutrients
2021
36 次引用
Frontiers in medicine
2021
6 次引用
Naunyn-Schmiedeberg's archives of …
2020
37 次引用
Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis.
Other
Toxicology mechanisms and …
2019
33 次引用
Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids.
RCT
Prostaglandins, leukotrienes, and …
2018
38 次引用
MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol.
Review
Medicines (Basel, Switzerland)
2018
23 次引用
Current pharmaceutical design
2017
168 次引用
Lipids
2017
21 次引用
BMC medicine
2015
230 次引用
Blood cells, molecules …
2015
53 次引用
Lipids
2012
28 次引用
The Journal of …
2010
32 次引用
Lipids in health …
2010
7 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 1.5-3 g/day
上限： No established UL
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 1% zinc chloride solution | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 200 mg | 5 weeks | Positive | -- |
| None | -- | Positive | -- |
最佳服用时间： With meals
Safety & Side Effects
已报告的副作用
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Fatigue
- ⚠ May worsen insulin sensitivity in some individuals
- ⚠ Liver fat accumulation (some formulations)
已知相互作用
- ● Diabetes medications (may affect insulin sensitivity)
- ● Anticoagulants (may have additive effects)
可耐受最高摄入量： No established UL
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Conjugated Linoleic Acid help with Chronic Inflammation?
Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that Conjugated Linoleic Acid may support Chronic Inflammation management. Our evidence grade is D (Very Early Research).
How much Conjugated Linoleic Acid should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 1.5-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Conjugated Linoleic Acid?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Fatigue, May worsen insulin sensitivity in some individuals, Liver fat accumulation (some formulations). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Conjugated Linoleic Acid and Chronic Inflammation?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.
Related Evidence
其他成分用于 Chronic Inflammation
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