Conjugated Linoleic Acid के लिए Chronic Inflammation
D अनुसंधान केवल प्रारंभिक शोध उपलब्ध है (प्रयोगशाला अध्ययन, केस रिपोर्ट)।Animal studies show CLA may have immunomodulatory effects via PPAR-gamma activation. Human evidence for immune-specific outcomes is limited and inconsistent, with some studies showing no significant benefit.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'immunecited.com';
const params = 'ingredient\u003Dcla\u0026condition\u003Dchronic\u002Dinflammation';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
D
निष्कर्ष
Animal studies show CLA may have immunomodulatory effects via PPAR-gamma activation. Human evidence for immune-specific outcomes is limited and inconsistent, with some studies showing no significant benefit.
Key Study Findings
Review
A perspective on the chemical structures and molecular mechanisms of curcumin and its derivatives and …
Dose: None
बनाम: None
Outcome: None
प्रभाव: None
None
जनसंख्या: Review of curcumin derivatives in cancer treatment
Review
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Dose: None
बनाम: None
Outcome: None
प्रभाव: None
None
जनसंख्या: review of dietary polyphenols in type 2 diabetes mellitus management
Review
Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects …
Dose: None
बनाम: None
Outcome: Musculoskeletal aging and cellular senescence
प्रभाव: None
None
जनसंख्या: Aging adults with musculoskeletal decline (review)
Review
Retracted: Chronic Epipharyngitis Treated with Epipharyngeal Abrasion Therapy: Symptoms, Diagnosis, Pathogenesis, and Treatment Outcomes.
Dose: 1% zinc chloride solution
बनाम: None
Outcome: Chronic epipharyngitis symptom improvement
प्रभाव: None
None
जनसंख्या: Patients with chronic epipharyngitis (retracted publication)
Systematic Review
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Dose: None
बनाम: None
Outcome: None
प्रभाव: None
None
जनसंख्या: Review of TCM compounds in autoimmune skin diseases
Other
The omega effect: Harnessing fish oil for health.
Dose: None
बनाम: None
Outcome: None
प्रभाव: None
None
जनसंख्या: None
Key Statistics
3
अध्ययन
150
प्रतिभागी
↔
Mixed
D
ग्रेड
Referenced Papers
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Review
Nutrients
2025
32 उद्धरण
International journal of …
2025
5 उद्धरण
International journal of …
2025
2 उद्धरण
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Systematic Review
Frontiers in immunology
2025
1 उद्धरण
Atherosclerosis
2025
JMA journal
2025
Journal of clinical …
2024
29 उद्धरण
Molecular nutrition & …
2024
15 उद्धरण
Newborn (Clarksville, Md.)
2024
9 उद्धरण
Nutrients
2024
7 उद्धरण
Advances in rheumatology …
2024
Current molecular pharmacology
2023
72 उद्धरण
Immunological investigations
2023
13 उद्धरण
International immunopharmacology
2023
8 उद्धरण
International journal of …
2022
26 उद्धरण
Effect of omega-3 fatty acids on the telomere length: A mini meta-analysis of clinical trials.
Meta-Analysis
Biomolecular concepts
2022
18 उद्धरण
Foods (Basel, Switzerland)
2022
9 उद्धरण
Nutrients
2021
36 उद्धरण
Frontiers in medicine
2021
6 उद्धरण
Naunyn-Schmiedeberg's archives of …
2020
37 उद्धरण
Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis.
Other
Toxicology mechanisms and …
2019
33 उद्धरण
Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids.
RCT
Prostaglandins, leukotrienes, and …
2018
38 उद्धरण
MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol.
Review
Medicines (Basel, Switzerland)
2018
23 उद्धरण
Current pharmaceutical design
2017
168 उद्धरण
Lipids
2017
21 उद्धरण
BMC medicine
2015
230 उद्धरण
Blood cells, molecules …
2015
53 उद्धरण
Lipids
2012
28 उद्धरण
The Journal of …
2010
32 उद्धरण
Lipids in health …
2010
7 उद्धरण
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
सामान्य रूप से उपयोग की जाने वाली खुराकें
- general:
- 1.5-3 g/day
अधिकतम सीमा: No established UL
अनुसंधान में अध्ययन की गई खुराकें
| खुराक | अवधि | प्रभाव | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 1% zinc chloride solution | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 200 mg | 5 weeks | Positive | -- |
| None | -- | Positive | -- |
सेवन का सर्वोत्तम समय: With meals
Safety & Side Effects
रिपोर्ट किए गए दुष्प्रभाव
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Fatigue
- ⚠ May worsen insulin sensitivity in some individuals
- ⚠ Liver fat accumulation (some formulations)
ज्ञात अंतःक्रियाएँ
- ● Diabetes medications (may affect insulin sensitivity)
- ● Anticoagulants (may have additive effects)
सहनीय अधिकतम सेवन: No established UL
कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।
Frequently Asked Questions
Does Conjugated Linoleic Acid help with Chronic Inflammation?
Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that Conjugated Linoleic Acid may support Chronic Inflammation management. Our evidence grade is D (Very Early Research).
How much Conjugated Linoleic Acid should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 1.5-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Conjugated Linoleic Acid?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Fatigue, May worsen insulin sensitivity in some individuals, Liver fat accumulation (some formulations). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Conjugated Linoleic Acid and Chronic Inflammation?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.
Related Evidence
इसके लिए अन्य सामग्री Chronic Inflammation
References
- [1] Monika Martiniakova et al.. Nutrients. 2025. Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus. doi:10.3390/nu17020275 PubMed
- [2] Angela Falvino et al.. Int J Mol Sci. 2025. Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of Exercise. doi:10.3390/ijms26157573 PubMed
- [3] Lujie Zhu et al.. Int J Oncol. 2025. A perspective on the chemical structures and molecular mechanisms of curcumin and its derivatives and analogs in cancer treatment (Review). doi:10.3892/ijo.2025.5782 PubMed
- [4] Yuhan Wang et al.. Front Immunol. 2025. Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases. doi:10.3389/fimmu.2025.1629288 PubMed
- [5] Jacques D Barth. Atherosclerosis. 2025. The omega effect: Harnessing fish oil for health. doi:10.1016/j.atherosclerosis.2025.120461 PubMed
- [6] Yasuaki Harabuchi et al.. JMA J. 2025. Retracted: Chronic Epipharyngitis Treated with Epipharyngeal Abrasion Therapy: Symptoms, Diagnosis, Pathogenesis, and Treatment Outcomes. doi:10.31662/jmaj.2024-0437 PubMed
- [7] Houriah Yasir Nukaly et al.. J Clin Med. 2024. Oral Lichen Planus: A Narrative Review Navigating Etiologies, Clinical Manifestations, Diagnostics, and Therapeutic Approaches. doi:10.3390/jcm13175280 PubMed
- [8] Qi Sun et al.. Mol Nutr Food Res. 2024. Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis Mice. doi:10.1002/mnfr.202300446 PubMed
- [9] Akhil Maheshwari et al.. Newborn (Clarksville). 2024. Milk Fat Globules: 2024 Updates. doi:10.5005/jp-journals-11002-0085 PubMed
- [10] Lucas de Freitas Pedrosa et al.. Nutrients. 2024. From Structure to Function: How Prebiotic Diversity Shapes Gut Integrity and Immune Balance. doi:10.3390/nu16244286 PubMed
- [11] Daniele Scherer et al.. Adv Rheumatol. 2024. Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial-the DIETA trial. doi:10.1186/s42358-024-00389-5 PubMed
- [12] Elham Abdollahi et al.. Curr Mol Pharmacol. 2023. Immunomodulatory Therapeutic Effects of Curcumin on M1/M2 Macrophage Polarization in Inflammatory Diseases. doi:10.2174/1874467215666220324114624 PubMed
- [13] Alexandre Kleber Silveira et al.. Immunol Invest. 2023. Sodium Butyrate Protects Against Intestinal Oxidative Damage and Neuroinflammation in the Prefrontal Cortex of Ulcerative Colitis Mice Model. doi:10.1080/08820139.2023.2244967 PubMed
- [14] Zhanwei Zhang et al.. Int Immunopharmacol. 2023. Maresin1: A multifunctional regulator in inflammatory bone diseases. doi:10.1016/j.intimp.2023.110308 PubMed
- [15] Mark F McCarty et al.. Int J Mol Sci. 2022. Targeting Sirt1, AMPK, Nrf2, CK2, and Soluble Guanylate Cyclase with Nutraceuticals: A Practical Strategy for Preserving Bone Mass. doi:10.3390/ijms23094776 PubMed
- [16] Sawan Ali et al.. Biomol Concepts. 2022. Effect of omega-3 fatty acids on the telomere length: A mini meta-analysis of clinical trials. doi:10.1515/bmc-2021-0024 PubMed
- [17] Monica Tognocchi et al.. Foods. 2022. Supplementation of Enriched Polyunsaturated Fatty Acids and CLA Cheese on High Fat Diet: Effects on Lipid Metabolism and Fat Profile. doi:10.3390/foods11030398 PubMed
- [18] Rosaria Varì et al.. Nutrients. 2021. Obesity-Associated Inflammation: Does Curcumin Exert a Beneficial Role? doi:10.3390/nu13031021 PubMed
- [19] Sanja Lalic-Cosic et al.. Front Med (Lausanne). 2021. Phosphatidylserine Exposing Extracellular Vesicles in Pre-eclamptic Patients. doi:10.3389/fmed.2021.761453 PubMed
- [20] Yuxin Xian et al.. Naunyn Schmiedebergs Arch Pharmacol. 2020. Resveratrol prevents diabetic nephropathy by reducing chronic inflammation and improving the blood glucose memory effect in non-obese diabetic mice. doi:10.1007/s00210-019-01777-1 PubMed
- [21] Mohita Sharma et al.. Toxicol Mech Methods. 2019. Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis. doi:10.1080/15376516.2018.1553220 PubMed
- [22] Gregory C Shearer et al.. Prostaglandins Leukot Essent Fatty Acids. 2018. Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids. doi:10.1016/j.plefa.2017.10.006 PubMed
- [23] Jean-Jacques Michaille et al.. Medicines (Basel). 2018. MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol. doi:10.3390/medicines5030074 PubMed
- [24] Morteza Ghandadi et al.. Curr Pharm Des. 2017. Curcumin: An Effective Inhibitor of Interleukin-6. doi:10.2174/1381612822666161006151605 PubMed
- [25] Jake M Olson et al.. Lipids. 2017. A Comparison of the Anti-Inflammatory Effects of Cis-9, Trans-11 Conjugated Linoleic Acid to Celecoxib in the Collagen-Induced Arthritis Model. doi:10.1007/s11745-016-4228-8 PubMed
- [26] Gerwyn Morris et al.. BMC Med. 2015. The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders. doi:10.1186/s12916-015-0310-y PubMed
- [27] Ahmed A Daak et al.. Blood Cells Mol Dis. 2015. Omega 3 (n-3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with … doi:10.1016/j.bcmd.2015.03.014 PubMed
- [28] Meaghan Reardon et al.. Lipids. 2012. Oleic acid attenuates trans-10,cis-12 conjugated linoleic acid-mediated inflammatory gene expression in human adipocytes. doi:10.1007/s11745-012-3711-0 PubMed
- [29] Shane M Huebner et al.. J Nutr. 2010. Individual isomers of conjugated linoleic acid reduce inflammation associated with established collagen-induced arthritis in DBA/1 mice. doi:10.3945/jn.109.120527 PubMed
- [30] Aurelio Ocaña et al.. Lipids Health Dis. 2010. In vitro study of the effect of diesterified alkoxyglycerols with conjugated linoleic acid on adipocyte inflammatory mediators. doi:10.1186/1476-511X-9-36 PubMed
FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।