Conjugated Linoleic Acid ： Chronic Inflammation
D 研究 予備的な研究（実験室研究、症例報告）のみが存在します。Animal studies show CLA may have immunomodulatory effects via PPAR-gamma activation. Human evidence for immune-specific outcomes is limited and inconsistent, with some studies showing no significant benefit.
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D
結論
Animal studies show CLA may have immunomodulatory effects via PPAR-gamma activation. Human evidence for immune-specific outcomes is limited and inconsistent, with some studies showing no significant benefit.
Key Study Findings
Review
A perspective on the chemical structures and molecular mechanisms of curcumin and its derivatives and …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Review of curcumin derivatives in cancer treatment
Review
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: review of dietary polyphenols in type 2 diabetes mellitus management
Review
Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects …
Dose: None
vs: None
Outcome: Musculoskeletal aging and cellular senescence
効果: None
None
対象集団: Aging adults with musculoskeletal decline (review)
Review
Retracted: Chronic Epipharyngitis Treated with Epipharyngeal Abrasion Therapy: Symptoms, Diagnosis, Pathogenesis, and Treatment Outcomes.
Dose: 1% zinc chloride solution
vs: None
Outcome: Chronic epipharyngitis symptom improvement
効果: None
None
対象集団: Patients with chronic epipharyngitis (retracted publication)
Systematic Review
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Review of TCM compounds in autoimmune skin diseases
Other
The omega effect: Harnessing fish oil for health.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Key Statistics
3
研究数
150
参加者数
↔
Mixed
D
グレード
Referenced Papers
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Review
Nutrients
2025
32 件の引用
International journal of …
2025
5 件の引用
International journal of …
2025
2 件の引用
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Systematic Review
Frontiers in immunology
2025
1 件の引用
Atherosclerosis
2025
JMA journal
2025
Journal of clinical …
2024
29 件の引用
Molecular nutrition & …
2024
15 件の引用
Newborn (Clarksville, Md.)
2024
9 件の引用
Nutrients
2024
7 件の引用
Advances in rheumatology …
2024
Current molecular pharmacology
2023
72 件の引用
Immunological investigations
2023
13 件の引用
International immunopharmacology
2023
8 件の引用
International journal of …
2022
26 件の引用
Effect of omega-3 fatty acids on the telomere length: A mini meta-analysis of clinical trials.
Meta-Analysis
Biomolecular concepts
2022
18 件の引用
Foods (Basel, Switzerland)
2022
9 件の引用
Nutrients
2021
36 件の引用
Frontiers in medicine
2021
6 件の引用
Naunyn-Schmiedeberg's archives of …
2020
37 件の引用
Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis.
Other
Toxicology mechanisms and …
2019
33 件の引用
Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids.
RCT
Prostaglandins, leukotrienes, and …
2018
38 件の引用
MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol.
Review
Medicines (Basel, Switzerland)
2018
23 件の引用
Current pharmaceutical design
2017
168 件の引用
Lipids
2017
21 件の引用
BMC medicine
2015
230 件の引用
Blood cells, molecules …
2015
53 件の引用
Lipids
2012
28 件の引用
The Journal of …
2010
32 件の引用
Lipids in health …
2010
7 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 1.5-3 g/day
上限量： No established UL
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 1% zinc chloride solution | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 200 mg | 5 weeks | Positive | -- |
| None | -- | Positive | -- |
推奨摂取タイミング： With meals
Safety & Side Effects
報告されている副作用
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Fatigue
- ⚠ May worsen insulin sensitivity in some individuals
- ⚠ Liver fat accumulation (some formulations)
既知の相互作用
- ● Diabetes medications (may affect insulin sensitivity)
- ● Anticoagulants (may have additive effects)
耐容上限摂取量： No established UL
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Conjugated Linoleic Acid help with Chronic Inflammation?
Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that Conjugated Linoleic Acid may support Chronic Inflammation management. Our evidence grade is D (Very Early Research).
How much Conjugated Linoleic Acid should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 1.5-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Conjugated Linoleic Acid?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Fatigue, May worsen insulin sensitivity in some individuals, Liver fat accumulation (some formulations). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Conjugated Linoleic Acid and Chronic Inflammation?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.
Related Evidence
に関する他の成分： Chronic Inflammation
References
- [1] Monika Martiniakova et al.. Nutrients. 2025. Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus. doi:10.3390/nu17020275 PubMed
- [2] Angela Falvino et al.. Int J Mol Sci. 2025. Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of Exercise. doi:10.3390/ijms26157573 PubMed
- [3] Lujie Zhu et al.. Int J Oncol. 2025. A perspective on the chemical structures and molecular mechanisms of curcumin and its derivatives and analogs in cancer treatment (Review). doi:10.3892/ijo.2025.5782 PubMed
- [4] Yuhan Wang et al.. Front Immunol. 2025. Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases. doi:10.3389/fimmu.2025.1629288 PubMed
- [5] Jacques D Barth. Atherosclerosis. 2025. The omega effect: Harnessing fish oil for health. doi:10.1016/j.atherosclerosis.2025.120461 PubMed
- [6] Yasuaki Harabuchi et al.. JMA J. 2025. Retracted: Chronic Epipharyngitis Treated with Epipharyngeal Abrasion Therapy: Symptoms, Diagnosis, Pathogenesis, and Treatment Outcomes. doi:10.31662/jmaj.2024-0437 PubMed
- [7] Houriah Yasir Nukaly et al.. J Clin Med. 2024. Oral Lichen Planus: A Narrative Review Navigating Etiologies, Clinical Manifestations, Diagnostics, and Therapeutic Approaches. doi:10.3390/jcm13175280 PubMed
- [8] Qi Sun et al.. Mol Nutr Food Res. 2024. Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis Mice. doi:10.1002/mnfr.202300446 PubMed
- [9] Akhil Maheshwari et al.. Newborn (Clarksville). 2024. Milk Fat Globules: 2024 Updates. doi:10.5005/jp-journals-11002-0085 PubMed
- [10] Lucas de Freitas Pedrosa et al.. Nutrients. 2024. From Structure to Function: How Prebiotic Diversity Shapes Gut Integrity and Immune Balance. doi:10.3390/nu16244286 PubMed
- [11] Daniele Scherer et al.. Adv Rheumatol. 2024. Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial-the DIETA trial. doi:10.1186/s42358-024-00389-5 PubMed
- [12] Elham Abdollahi et al.. Curr Mol Pharmacol. 2023. Immunomodulatory Therapeutic Effects of Curcumin on M1/M2 Macrophage Polarization in Inflammatory Diseases. doi:10.2174/1874467215666220324114624 PubMed
- [13] Alexandre Kleber Silveira et al.. Immunol Invest. 2023. Sodium Butyrate Protects Against Intestinal Oxidative Damage and Neuroinflammation in the Prefrontal Cortex of Ulcerative Colitis Mice Model. doi:10.1080/08820139.2023.2244967 PubMed
- [14] Zhanwei Zhang et al.. Int Immunopharmacol. 2023. Maresin1: A multifunctional regulator in inflammatory bone diseases. doi:10.1016/j.intimp.2023.110308 PubMed
- [15] Mark F McCarty et al.. Int J Mol Sci. 2022. Targeting Sirt1, AMPK, Nrf2, CK2, and Soluble Guanylate Cyclase with Nutraceuticals: A Practical Strategy for Preserving Bone Mass. doi:10.3390/ijms23094776 PubMed
- [16] Sawan Ali et al.. Biomol Concepts. 2022. Effect of omega-3 fatty acids on the telomere length: A mini meta-analysis of clinical trials. doi:10.1515/bmc-2021-0024 PubMed
- [17] Monica Tognocchi et al.. Foods. 2022. Supplementation of Enriched Polyunsaturated Fatty Acids and CLA Cheese on High Fat Diet: Effects on Lipid Metabolism and Fat Profile. doi:10.3390/foods11030398 PubMed
- [18] Rosaria Varì et al.. Nutrients. 2021. Obesity-Associated Inflammation: Does Curcumin Exert a Beneficial Role? doi:10.3390/nu13031021 PubMed
- [19] Sanja Lalic-Cosic et al.. Front Med (Lausanne). 2021. Phosphatidylserine Exposing Extracellular Vesicles in Pre-eclamptic Patients. doi:10.3389/fmed.2021.761453 PubMed
- [20] Yuxin Xian et al.. Naunyn Schmiedebergs Arch Pharmacol. 2020. Resveratrol prevents diabetic nephropathy by reducing chronic inflammation and improving the blood glucose memory effect in non-obese diabetic mice. doi:10.1007/s00210-019-01777-1 PubMed
- [21] Mohita Sharma et al.. Toxicol Mech Methods. 2019. Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis. doi:10.1080/15376516.2018.1553220 PubMed
- [22] Gregory C Shearer et al.. Prostaglandins Leukot Essent Fatty Acids. 2018. Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids. doi:10.1016/j.plefa.2017.10.006 PubMed
- [23] Jean-Jacques Michaille et al.. Medicines (Basel). 2018. MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol. doi:10.3390/medicines5030074 PubMed
- [24] Morteza Ghandadi et al.. Curr Pharm Des. 2017. Curcumin: An Effective Inhibitor of Interleukin-6. doi:10.2174/1381612822666161006151605 PubMed
- [25] Jake M Olson et al.. Lipids. 2017. A Comparison of the Anti-Inflammatory Effects of Cis-9, Trans-11 Conjugated Linoleic Acid to Celecoxib in the Collagen-Induced Arthritis Model. doi:10.1007/s11745-016-4228-8 PubMed
- [26] Gerwyn Morris et al.. BMC Med. 2015. The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders. doi:10.1186/s12916-015-0310-y PubMed
- [27] Ahmed A Daak et al.. Blood Cells Mol Dis. 2015. Omega 3 (n-3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with … doi:10.1016/j.bcmd.2015.03.014 PubMed
- [28] Meaghan Reardon et al.. Lipids. 2012. Oleic acid attenuates trans-10,cis-12 conjugated linoleic acid-mediated inflammatory gene expression in human adipocytes. doi:10.1007/s11745-012-3711-0 PubMed
- [29] Shane M Huebner et al.. J Nutr. 2010. Individual isomers of conjugated linoleic acid reduce inflammation associated with established collagen-induced arthritis in DBA/1 mice. doi:10.3945/jn.109.120527 PubMed
- [30] Aurelio Ocaña et al.. Lipids Health Dis. 2010. In vitro study of the effect of diesterified alkoxyglycerols with conjugated linoleic acid on adipocyte inflammatory mediators. doi:10.1186/1476-511X-9-36 PubMed
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