エビデンスに基づいた サプリメントレビュー
Every immune claim cited.
We read the immune health studies so you don't have to.
Evidence-based supplement research you can trust. We analyze peer-reviewed clinical studies from PubMed and grade every supplement ingredient on a transparent A–D scale. No sponsored rankings, no manufacturer influence — just science.
Featured Ingredients
Vitamin D
vitaminModulates both innate and adaptive immune responses by maintaining epithelial barrier integrity and boosting production of antimicrobial peptides (cathelicidin LL-37 …
Zinc
mineralEssential trace mineral required for development and function of neutrophils, NK cells, and T lymphocytes; acts as a signaling molecule …
Garlic
herbOrganosulfur compounds (allicin, diallyl disulfide) stimulate macrophage, lymphocyte, and NK cell activity; modulate cytokine secretion; exhibit broad-spectrum antimicrobial activity via …
Pelargonium sidoides
herbRoot extract stimulates interferon production, enhances phagocytic activity, and modulates cytokine release; exhibits combined immunomodulatory, antibacterial, and antiviral properties through …
Reishi Mushroom
mushroomBeta-glucans bind to pattern recognition receptors (Dectin-1, CR3) on macrophages and dendritic cells, activating innate immune cascades; triterpenes modulate NF-kB …
Lactobacillus rhamnosus GG
probioticEnhances intestinal barrier integrity and stimulates GALT; promotes IgA secretion; modulates systemic immune responses by balancing pro- and anti-inflammatory cytokines; …
Top Conditions
Acute Bronchitis
5% of adults annually
Allergic Rhinitis
10-30% of adults globally; 40% of children
Gut Immune Health
Gut dysbiosis affects an estimated 25-45% of adults
Post-Viral Fatigue
10-35% of individuals after certain viral infections; ~10% post-COVID
Chronic Inflammation
Estimated 50-60% of adults have at least one inflammatory biomarker elevation
Recurrent Infections
~25% of primary care patients report recurrent infections
Recent Evidence Updates
Popular Comparisons
Latest Research
Am J Clin Nutr · 1991
Omega-3 fatty acids in health and disease and in growth and development.
J Am Coll Nutr · 2002
Omega-3 fatty acids in inflammation and autoimmune diseases.
Arch Intern Med · 2009
Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey.
Crit Rev Immunol · 2012
M1 and M2 Macrophages: Oracles of Health and Disease.
Adv Nutr · 2013
Discovery of human zinc deficiency: its impact on human health and disease.
J Autoimmun · 2019
Systemic lupus erythematosus: Diagnosis and clinical management.
Guides & Resources
Exercise and Immune Function: The J-Curve, Recovery, and Nutritional Support
The relationship between exercise and immune function has been a subject of scientific inquiry since the observation in the 1980s and 1990s that elite endurance …
lifestyleSeasonal Immune Support: Evidence-Based Strategies for Fall, Winter, and Beyond
The human immune system does not operate in isolation from the environment, and seasonal changes in temperature, humidity, daylight hours, and pathogen circulation patterns all …
safetyImmune Supplement and Medication Interactions: What You Need to Know
Dietary supplements are often perceived as inherently safe because they are derived from natural sources, but many immune-support supplements contain pharmacologically active compounds that can …
Evidence Grading System
Every supplement claim on this site is graded on an A–D scale based on peer-reviewed clinical research from PubMed. Our algorithm evaluates study design (RCTs rank highest), consistency of results, sample sizes, and the overall body of evidence. No manufacturer sponsorship influences our grades.
Multiple randomized controlled trials (RCTs) or meta-analyses with consistent positive results and large sample sizes.
At least one RCT with mostly consistent results across studies. Evidence suggests benefit but more research may be needed.
Small studies or observational data with some positive signals. Promising but insufficient for strong recommendations.
In vitro studies, case reports, or pilot studies only. Early-stage research that requires clinical validation.
How It Works
広告なし。スポンサーランキングなし。科学だけ。
リサーチハブ
サプリメント成分に関するすべての臨床研究を PubMed で検索しています。
抽出
主要な知見（サンプルサイズ、研究タイプ、結果）を抽出しています。
グレード A から F
エビデンスを通知表のようにグレード付けします — A（強い）から F（否定的）まで。
明確な答え
数秒で明確な答えが得られます — このサプリメントは実際に効果が期待できるのか？
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FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。