Vitamin A ： Pediatric Immune Support
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。Vitamin A supplementation in deficient children may significantly reduce morbidity and mortality from measles and diarrheal disease. No nutritional deficiency is more consistently associated with increased infectious disease susceptibility than vitamin A deficiency.
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B
結論
Vitamin A supplementation in deficient children may significantly reduce morbidity and mortality from measles and diarrheal disease. No nutritional deficiency is more consistently associated with increased infectious disease susceptibility than vitamin A deficiency.
Key Study Findings
Review
n=26282
988 weeks
Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES.
Dose: 45%
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
Diet and nutritional factors in inflammatory bowel diseases.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: IBD patients (diet and nutrition)
Observational Study
n=61
260 weeks
Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease.
Dose: None
vs: None
Outcome: Vitamin and zinc status in IBD patients
効果: None
None
対象集団: Patients with inflammatory bowel disease
Review
Influence of mineral and vitamin supplements on pregnancy outcome.
Dose: None
vs: None
Outcome: Pregnancy outcome (birth weight, preeclampsia, NTD)
効果: None
None
対象集団: Pregnant women
Review
Cod liver oil, young children, and upper respiratory tract infections.
Dose: None
vs: None
Outcome: vitamin D levels
効果: None
None
対象集団: children
Randomized Controlled Trial
n=584
52 weeks
Double-blind
Interaction of zinc or vitamin A supplementation and specific parasite infections on Mexican infants' growth: …
Dose: Zinc 20mg/day; VitA 20000-45000 IU every 2 months
vs: Placebo
Outcome: Interaction of zinc or vitamin A supplementation and …
効果: None
p<0.05
対象集団: None
Key Statistics
10
研究数
5000
参加者数
↑
Positive
B
グレード
Referenced Papers
Nutrients
2020
75 件の引用
World journal of …
2016
238 件の引用
Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease.
Other
Journal of pediatric …
2014
38 件の引用
European journal of …
2012
225 件の引用
Journal of the …
2010
11 件の引用
European journal of …
2009
24 件の引用
The British journal …
2002
358 件の引用
The Urologic clinics …
2002
20 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 700-900 mcg RAE/day
- immunesupport:
- 900 mcg RAE/day
上限量： 3,000 mcg RAE/day (preformed vitamin A)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| 45% | 988 weeks | Positive | 26282 |
| None | -- | Mixed | -- |
| None | 260 weeks | Positive | 61 |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| Zinc 20mg/day; VitA 20000-45000 IU every 2 months | 52 weeks | Mixed | 584 |
| Probiotics, prebiotics, fatty acids, vitamins | -- | Positive | -- |
| Various nutrients (selenium, vitamins, green tea) | -- | Positive | -- |
推奨摂取タイミング： With meals containing fat
Safety & Side Effects
報告されている副作用
- ⚠ Hepatotoxicity at chronic high doses
- ⚠ Birth defects (teratogenic at high doses during pregnancy)
- ⚠ Nausea and headache
- ⚠ Bone density reduction with long-term excess
既知の相互作用
- ● Retinoid medications (additive toxicity risk)
- ● Orlistat (reduces absorption of fat-soluble vitamins)
- ● Alcohol (increases hepatotoxicity risk)
- ● Tetracycline antibiotics (increased intracranial pressure risk)
耐容上限摂取量： 3,000 mcg RAE/day (preformed vitamin A)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Vitamin A help with Pediatric Immune Support?
Based on 10 studies with 5,000 participants, there is moderate evidence from clinical studies that Vitamin A may support Pediatric Immune Support management. Our evidence grade is B (Good Evidence).
How much Vitamin A should I take for Pediatric Immune Support?
Studies have used various dosages. A commonly studied range is 700-900 mcg RAE/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin A?
Reported side effects may include Hepatotoxicity at chronic high doses, Birth defects (teratogenic at high doses during pregnancy), Nausea and headache, Bone density reduction with long-term excess. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin A and Pediatric Immune Support?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 5,000 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Pediatric Immune Support
References
- [1] Carroll A Reider et al.. Nutrients. 2020. Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES. doi:10.3390/nu12061735 PubMed
- [2] Danuta Owczarek et al.. World J Gastroenterol. 2016. Diet and nutritional factors in inflammatory bowel diseases. doi:10.3748/wjg.v22.i3.895 PubMed
- [3] Neha R Santucci et al.. J Pediatr Gastroenterol Nutr. 2014. Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease. doi:10.1097/MPG.0000000000000477 PubMed
- [4] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
- [5] Linda A Linday. J Am Coll Nutr. 2010. Cod liver oil, young children, and upper respiratory tract infections. doi:10.1080/07315724.2010.10719894 PubMed
- [6] J L Rosado et al.. Eur J Clin Nutr. 2009. Interaction of zinc or vitamin A supplementation and specific parasite infections on Mexican infants' growth: a randomized clinical trial. doi:10.1038/ejcn.2009.53 PubMed
- [7] Philip C Calder et al.. Br J Nutr. 2002. The immune system: a target for functional foods? doi:10.1079/BJN2002682 PubMed
- [8] Ashish M Kamat et al.. Urol Clin North Am. 2002. Chemoprevention of bladder cancer. doi:10.1016/s0094-0143(02)00022-8 PubMed
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