Vitamin A 用于 儿童免疫支持
B 证据 至少一项随机试验支持这一结论，结果基本一致。Vitamin A supplementation in deficient children may significantly reduce morbidity and mortality from measles and diarrheal disease. No nutritional deficiency is more consistently associated with increased infectious disease susceptibility than vitamin A deficiency.
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B
结论
Vitamin A supplementation in deficient children may significantly reduce morbidity and mortality from measles and diarrheal disease. No nutritional deficiency is more consistently associated with increased infectious disease susceptibility than vitamin A deficiency.
Key Study Findings
Review
n=26282
988 weeks
Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES.
Dose: 45%
vs: None
Outcome: None
效果: None
None
研究人群: None
Review
Diet and nutritional factors in inflammatory bowel diseases.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: IBD patients (diet and nutrition)
Observational Study
n=61
260 weeks
Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease.
Dose: None
vs: None
Outcome: Vitamin and zinc status in IBD patients
效果: None
None
研究人群: Patients with inflammatory bowel disease
Review
Influence of mineral and vitamin supplements on pregnancy outcome.
Dose: None
vs: None
Outcome: Pregnancy outcome (birth weight, preeclampsia, NTD)
效果: None
None
研究人群: Pregnant women
Review
Cod liver oil, young children, and upper respiratory tract infections.
Dose: None
vs: None
Outcome: vitamin D levels
效果: None
None
研究人群: children
Randomized Controlled Trial
n=584
52 weeks
Double-blind
Interaction of zinc or vitamin A supplementation and specific parasite infections on Mexican infants' growth: …
Dose: Zinc 20mg/day; VitA 20000-45000 IU every 2 months
vs: Placebo
Outcome: Interaction of zinc or vitamin A supplementation and …
效果: None
p<0.05
研究人群: None
Key Statistics
10
研究数量
5000
受试者
↑
Positive
B
等级
Referenced Papers
Nutrients
2020
75 次引用
World journal of …
2016
238 次引用
Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease.
Other
Journal of pediatric …
2014
38 次引用
European journal of …
2012
225 次引用
Journal of the …
2010
11 次引用
European journal of …
2009
24 次引用
The British journal …
2002
358 次引用
The Urologic clinics …
2002
20 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 700-900 mcg RAE/day
- immunesupport:
- 900 mcg RAE/day
上限： 3,000 mcg RAE/day (preformed vitamin A)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| 45% | 988 weeks | Positive | 26282 |
| None | -- | Mixed | -- |
| None | 260 weeks | Positive | 61 |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| Zinc 20mg/day; VitA 20000-45000 IU every 2 months | 52 weeks | Mixed | 584 |
| Probiotics, prebiotics, fatty acids, vitamins | -- | Positive | -- |
| Various nutrients (selenium, vitamins, green tea) | -- | Positive | -- |
最佳服用时间： With meals containing fat
Safety & Side Effects
已报告的副作用
- ⚠ Hepatotoxicity at chronic high doses
- ⚠ Birth defects (teratogenic at high doses during pregnancy)
- ⚠ Nausea and headache
- ⚠ Bone density reduction with long-term excess
已知相互作用
- ● Retinoid medications (additive toxicity risk)
- ● Orlistat (reduces absorption of fat-soluble vitamins)
- ● Alcohol (increases hepatotoxicity risk)
- ● Tetracycline antibiotics (increased intracranial pressure risk)
可耐受最高摄入量： 3,000 mcg RAE/day (preformed vitamin A)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Vitamin A help with 儿童免疫支持?
Based on 10 studies with 5,000 participants, there is moderate evidence from clinical studies that Vitamin A may support 儿童免疫支持 management. Our evidence grade is B (Good Evidence).
How much Vitamin A should I take for 儿童免疫支持?
Studies have used various dosages. A commonly studied range is 700-900 mcg RAE/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin A?
Reported side effects may include Hepatotoxicity at chronic high doses, Birth defects (teratogenic at high doses during pregnancy), Nausea and headache, Bone density reduction with long-term excess. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin A and 儿童免疫支持?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 5,000 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 儿童免疫支持
References
- [1] Carroll A Reider et al.. Nutrients. 2020. Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES. doi:10.3390/nu12061735 PubMed
- [2] Danuta Owczarek et al.. World J Gastroenterol. 2016. Diet and nutritional factors in inflammatory bowel diseases. doi:10.3748/wjg.v22.i3.895 PubMed
- [3] Neha R Santucci et al.. J Pediatr Gastroenterol Nutr. 2014. Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease. doi:10.1097/MPG.0000000000000477 PubMed
- [4] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
- [5] Linda A Linday. J Am Coll Nutr. 2010. Cod liver oil, young children, and upper respiratory tract infections. doi:10.1080/07315724.2010.10719894 PubMed
- [6] J L Rosado et al.. Eur J Clin Nutr. 2009. Interaction of zinc or vitamin A supplementation and specific parasite infections on Mexican infants' growth: a randomized clinical trial. doi:10.1038/ejcn.2009.53 PubMed
- [7] Philip C Calder et al.. Br J Nutr. 2002. The immune system: a target for functional foods? doi:10.1079/BJN2002682 PubMed
- [8] Ashish M Kamat et al.. Urol Clin North Am. 2002. Chemoprevention of bladder cancer. doi:10.1016/s0094-0143(02)00022-8 PubMed
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