What are the side effects of Lactobacillus rhamnosus GG?

Potential side effects include: Mild bloating and gas (usually transient), Rare: bacteremia in severely immunocompromised patients, Generally very well tolerated.

What is Lactobacillus rhamnosus GG and how does it support immunity?

Lactobacillus rhamnosus GG (LGG) is one of the most extensively studied probiotic strains. Research suggests it may strengthen gut barrier function, stimulate secretory IgA production, and reduce the incidence and duration of respiratory and gastrointestinal infections.

What dosage of Lactobacillus rhamnosus GG has been used in studies?

Clinical trials have used LGG at doses of 1 billion to 10 billion CFU per day, with most pediatric studies using 1–5 billion CFU and adult studies using 5–10 billion CFU. Supplementation periods typically range from 4 weeks to 6 months.

What are the potential side effects of Lactobacillus rhamnosus GG?

LGG is generally recognized as safe for most populations, including children. Mild bloating or gas may occur initially. Caution is advised for severely immunocompromised individuals or those with central venous catheters, where rare cases of bacteremia have been reported.

Lactobacillus rhamnosus GG

probiotic

Also known as: LGG, Lacticaseibacillus rhamnosus GG

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About

LGG is one of the most extensively studied probiotic strains worldwide. It enhances intestinal barrier integrity and stimulates gut-associated lymphoid tissue (GALT), promotes IgA secretion, and modulates systemic immune responses by balancing pro- and anti-inflammatory cytokines. Systematic reviews show reduced incidence and duration of upper respiratory infections.

How It Works

Enhances intestinal barrier integrity and stimulates GALT; promotes IgA secretion; modulates systemic immune responses by balancing pro- and anti-inflammatory cytokines; competitively excludes pathogens from intestinal epithelium.

Evidence For Conditions

Condition	Grade	Studies	Participants
Gut Immune Health	B	20	3000	View →

Side Effects

Mild bloating and gas (usually transient)
Rare: bacteremia in severely immunocompromised patients
Generally very well tolerated

Drug & Supplement Interactions

Antibiotics (may reduce probiotic effectiveness; space doses 2+ hours apart)
Immunosuppressant medications (caution in severely immunocompromised patients)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Bifidobacterium lactis Saccharomyces boulardii

Quick Facts

Dosage: General: 10-20 billion CFU/day
Forms: capsule powder chewable sachet
Natural Sources: Fermented dairy products (specific strain requires supplementation)
Upper Limit: No established UL
Best Time: With or without food; consistency matters more than timing

Evidence Summary

Gut Immune Health B

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.