What is the recommended dosage for Saccharomyces boulardii?

Acute: 250 mg 2x/day; General: 250-500 mg/day (5-10 billion CFU)

What are the side effects of Saccharomyces boulardii?

Potential side effects include: Mild bloating and gas, Rare: fungemia in severely immunocompromised or ICU patients with central lines, Constipation (rare).

What is Saccharomyces boulardii and how does it support immune health?

Saccharomyces boulardii is a probiotic yeast with extensive clinical evidence for gastrointestinal and immune support. It may help maintain gut barrier integrity, stimulate secretory IgA production, and modulate inflammatory responses in the intestinal mucosa.

What dosage of Saccharomyces boulardii has been used in studies?

Clinical trials have used S. boulardii at doses of 250–1,000 mg per day (equivalent to 5–10 billion CFU), typically for 1 to 4 weeks. It is one of the most extensively studied probiotic organisms for antibiotic-associated and infectious diarrhea.

What are the potential side effects of Saccharomyces boulardii?

S. boulardii is generally well tolerated. Mild flatulence may occur. It should be avoided in critically ill patients with central venous catheters due to a small risk of fungemia. Unlike bacterial probiotics, it is not affected by antibiotics.

Saccharomyces boulardii

probiotic

Also known as: S. boulardii, Saccharomyces boulardii CNCM I-745

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About

S. boulardii is a non-pathogenic yeast that supports intestinal immune barrier function, enhances secretory IgA production, and modulates the inflammatory response. Uniquely resistant to antibiotics, enabling concurrent use during antibiotic therapy. Meta-analyses support efficacy for antibiotic-associated diarrhea and C. difficile prevention.

How It Works

Non-pathogenic yeast that supports intestinal immune barrier function; enhances secretory IgA production; uniquely antibiotic-resistant; neutralizes bacterial toxins and supports commensal flora recovery.

Evidence For Conditions

Condition	Grade	Studies	Participants
Gut Immune Health	B	15	3000	View →

Side Effects

Mild bloating and gas
Rare: fungemia in severely immunocompromised or ICU patients with central lines
Constipation (rare)

Drug & Supplement Interactions

Antifungal medications (will kill S. boulardii; do not combine)
Uniquely safe to use with antibiotics (inherent antibiotic resistance)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Bifidobacterium lactis Lactobacillus rhamnosus GG

Quick Facts

Dosage: Acute: 250 mg 2x/day; General: 250-500 mg/day (5-10 billion CFU)
Forms: capsule powder sachet
Natural Sources: Lychee fruit skin, Mangosteen (natural source of the strain)
Upper Limit: No established UL
Best Time: Can be taken with antibiotics (uniquely antibiotic-resistant)

Evidence Summary

Gut Immune Health B

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.