Iron 用于 儿童免疫支持
C 证据 来自小型研究的证据有限，但存在一些积极信号。Iron supplementation in deficient children may help restore lymphocyte and neutrophil function. However, excess iron may feed pathogens and worsen infections. Supplementation should be guided by documented deficiency status.
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C
结论
Iron supplementation in deficient children may help restore lymphocyte and neutrophil function. However, excess iron may feed pathogens and worsen infections. Supplementation should be guided by documented deficiency status.
Key Study Findings
Review
Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Systematic Review and Meta-Analysis
n=7014
Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis.
Dose: None
vs: Placebo
效果: Standardized mean differences reported for each element and disease combination (specific values not
None
In Vitro
Microenvironment-responsive recombinant collagen XVII-based composite microneedles for the treatment of androgenetic alopecia.
Dose: None
vs: Minoxidil
Outcome: Hair regeneration in AGA mice
效果: None
None
研究人群: AGA mouse model
Review
Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?
Dose: None
vs: None
Outcome: Micronutrient deficiency management in pediatric IBD
效果: None
None
研究人群: Children with inflammatory bowel disease (review)
Other
Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis.
Dose: None
vs: Uncoated EcN and UC model mice
Outcome: UC inflammation and probiotic intestinal retention
效果: None
None
研究人群: Obese C57 mice with DSS-induced UC
Review
Frontal Fibrosing Alopecia in Men: A Review of the Literature.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Review of frontal fibrosing alopecia in men
Key Statistics
5
研究数量
400
受试者
↑
Positive
C
等级
Referenced Papers
Acta biomaterialia
2025
13 次引用
Cureus
2025
8 次引用
Nutrients
2025
4 次引用
Colloids and surfaces. …
2025
4 次引用
Journal of clinical …
2025
1 次引用
Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis.
Meta-Analysis
Nutrition reviews
2025
Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice.
Other
Journal of pineal …
2024
9 次引用
International journal of …
2024
3 次引用
Interventions for preventing the progression of autosomal dominant polycystic kidney disease.
Systematic Review
The Cochrane database …
2024
1 次引用
Retrospective evaluation of clinical profile and comorbidities in patients with alopecia areata.
Other
Northern clinics of …
2022
7 次引用
Clinical reviews in …
2021
304 次引用
Biomedicines
2021
27 次引用
Endocrine-related cancer
2021
26 次引用
BMC veterinary research
2021
24 次引用
World journal of …
2021
10 次引用
BMC nephrology
2021
2 次引用
Journal of dairy …
2020
58 次引用
Journal of clinical …
2019
13 次引用
Dermatitis : contact, …
2019
7 次引用
Diabetes, obesity & …
2017
69 次引用
World journal of …
2016
238 次引用
Deutsches Arzteblatt international
2016
99 次引用
Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not?
Review
Digestive diseases (Basel, …
2016
41 次引用
Annals of dermatology
2016
27 次引用
Journal of sports …
2016
13 次引用
Neuromolecular medicine
2016
The Cochrane database …
2015
147 次引用
Der Internist
2015
Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine.
Review
Journal of immunological …
2014
13 次引用
International journal of …
2013
104 次引用
European journal of …
2012
225 次引用
Inflammatory bowel diseases
2012
224 次引用
Sleep medicine reviews
2012
139 次引用
Food and nutrition …
2009
122 次引用
Pharmacoepidemiology and drug …
2009
22 次引用
The Annals of …
2008
82 次引用
The Israel Medical …
2008
61 次引用
American journal of …
2007
61 次引用
Premenstrual syndrome.
Systematic Review
BMJ clinical evidence
2007
Cardiovascular research
2006
42 次引用
Clinical and experimental …
2006
22 次引用
Heart failure reviews
2006
22 次引用
Journal of pediatric …
2006
7 次引用
The British journal …
2002
358 次引用
Unsafe and potentially safe herbal therapies.
Meta-Analysis
American journal of …
1999
226 次引用
Dermatologic clinics
1998
121 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 8-18 mg/day
- deficiency:
- Per medical guidance based on ferritin levels
上限： 45 mg/day (elemental iron)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | 7014 |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| Disease-modifying agents (tolvaptan, etc.) | -- | Positive | -- |
| None | -- | Positive | -- |
最佳服用时间： On empty stomach with vitamin C for best absorption; avoid with calcium, coffee, or tea
Safety & Side Effects
已报告的副作用
- ⚠ Constipation (most common)
- ⚠ Nausea and stomach cramps
- ⚠ Dark or black stools
- ⚠ Iron overload with excessive supplementation (hemochromatosis risk)
已知相互作用
- ● Calcium supplements and dairy (reduce iron absorption by 50-60%)
- ● Proton pump inhibitors and H2 blockers (reduce absorption)
- ● Tetracycline and quinolone antibiotics (mutual absorption reduction)
- ● Levothyroxine (iron reduces thyroid hormone absorption)
可耐受最高摄入量： 45 mg/day (elemental iron)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Iron help with 儿童免疫支持?
Based on 5 studies with 400 participants, there is limited but promising evidence that Iron may support 儿童免疫支持 management. Our evidence grade is C (Some Evidence).
How much Iron should I take for 儿童免疫支持?
Studies have used various dosages. A commonly studied range is 8-18 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Iron?
Reported side effects may include Constipation (most common), Nausea and stomach cramps, Dark or black stools, Iron overload with excessive supplementation (hemochromatosis risk). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Iron and 儿童免疫支持?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 儿童免疫支持
References
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