Iron para Pediatric Immune Support

C Evidencia Evidencia limitada de estudios pequeños, pero existen algunas señales positivas.

Iron supplementation in deficient children may help restore lymphocyte and neutrophil function. However, excess iron may feed pathogens and worsen infections. Supplementation should be guided by documented deficiency status.

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Conclusión

Key Study Findings

Review

Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities.

Dose: None vs: None Outcome: None Efecto: None None

Población: None

Systematic Review and Meta-Analysis n=7014

Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis.

Dose: None vs: Placebo Efecto: Standardized mean differences reported for each element and disease combination (specific values not None

In Vitro

Microenvironment-responsive recombinant collagen XVII-based composite microneedles for the treatment of androgenetic alopecia.

Dose: None vs: Minoxidil Outcome: Hair regeneration in AGA mice Efecto: None None

Población: AGA mouse model

Review

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?

Dose: None vs: None Outcome: Micronutrient deficiency management in pediatric IBD Efecto: None None

Población: Children with inflammatory bowel disease (review)

Other

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis.

Dose: None vs: Uncoated EcN and UC model mice Outcome: UC inflammation and probiotic intestinal retention Efecto: None None

Población: Obese C57 mice with DSS-induced UC

Review

Frontal Fibrosing Alopecia in Men: A Review of the Literature.

Dose: None vs: None Outcome: None Efecto: None None

Población: Review of frontal fibrosing alopecia in men

Key Statistics

Estudios

400

Participantes

↑

Positive

Calificación

Referenced Papers

Microenvironment-responsive recombinant collagen XVII-based composite microneedles for the treatment of androgenetic alopecia. Other

Acta biomaterialia 2025 13 citas

Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities. Review

Cureus 2025 8 citas

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do? Review

Nutrients 2025 4 citas

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis. Other

Colloids and surfaces. … 2025 4 citas

Frontal Fibrosing Alopecia in Men: A Review of the Literature. Review

Journal of clinical … 2025 1 citas

Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis. Meta-Analysis

Nutrition reviews 2025

Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice. Other

Journal of pineal … 2024 9 citas

Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies. Other

International journal of … 2024 3 citas

Interventions for preventing the progression of autosomal dominant polycystic kidney disease. Systematic Review

The Cochrane database … 2024 1 citas

Retrospective evaluation of clinical profile and comorbidities in patients with alopecia areata. Other

Northern clinics of … 2022 7 citas

Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management. Review

Clinical reviews in … 2021 304 citas

Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike Protein. Other

Biomedicines 2021 27 citas

Role of circadian rhythm disorders on EMT and tumour-immune interactions in endocrine-related cancers. Review

Endocrine-related cancer 2021 26 citas

The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in … RCT

BMC veterinary research 2021 24 citas

Treatment of alopecia totalis/universalis/focalis with vitamin D and analogs: Three case reports and a literature review. Case Report

World journal of … 2021 10 citas

Hypokalaemic paralysis and metabolic alkalosis in a patient with Sjögren syndrome: a case report and literature review. Case Report

BMC nephrology 2021 2 citas

Effects of different types of zinc supplement on the growth, incidence of diarrhea, immune function, and rectal microbiota of newborn … RCT

Journal of dairy … 2020 58 citas

Restless Legs Syndrome in Chronic Kidney Disease: Is Iron or Inflammatory Status To Blame? Other

Journal of clinical … 2019 13 citas

Clinical Pearls on Sleep Management in Atopic Dermatitis. Review

Dermatitis : contact, … 2019 7 citas

Effects of combined low-dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non-invasive indices of steatosis and … RCT

Diabetes, obesity & … 2017 69 citas

Diet and nutritional factors in inflammatory bowel diseases. Review

World journal of … 2016 238 citas

The Diagnosis and Treatment of Hair and Scalp Diseases. Review

Deutsches Arzteblatt international 2016 99 citas

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? Review

Digestive diseases (Basel, … 2016 41 citas

Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia. Other

Annals of dermatology 2016 27 citas

The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise. Other

Journal of sports … 2016 13 citas

Protective Effects of AGE and Its Components on Neuroinflammation and Neurodegeneration. Other

Neuromolecular medicine 2016

Interventions for central serous chorioretinopathy: a network meta-analysis. Meta-Analysis

The Cochrane database … 2015 147 citas

[Drug treatment of alopecia]. Other

Der Internist 2015

Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine. Review

Journal of immunological … 2014 13 citas

Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Review

International journal of … 2013 104 citas

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 citas

Micronutrient deficiencies in inflammatory bowel disease: from A to zinc. Review

Inflammatory bowel diseases 2012 224 citas

Restless legs syndrome--theoretical roles of inflammatory and immune mechanisms. Review

Sleep medicine reviews 2012 139 citas

Effects of maternal zinc supplementation on pregnancy and lactation outcomes. Review

Food and nutrition … 2009 122 citas

Uses of proton pump inhibitors and serum potassium levels. Other

Pharmacoepidemiology and drug … 2009 22 citas

Management strategies for premenstrual syndrome/premenstrual dysphoric disorder. Meta-Analysis

The Annals of … 2008 82 citas

Hyperferritinemia in autoimmunity. Review

The Israel Medical … 2008 61 citas

Nonhematological benefits of iron. Review

American journal of … 2007 61 citas

Premenstrual syndrome. Systematic Review

BMJ clinical evidence 2007

Oxidative stress in aldosteronism. Review

Cardiovascular research 2006 42 citas

Eplerenone prevents adverse cardiac remodelling induced by pressure overload in atrial natriuretic peptide-null mice. Other

Clinical and experimental … 2006 22 citas

Metabolic and immunologic derangements in cardiac cachexia: where to from here? Review

Heart failure reviews 2006 22 citas

Premenstrual syndrome and premenstrual dysphoric disorder in adolescence. Review

Journal of pediatric … 2006 7 citas

The immune system: a target for functional foods? Review

The British journal … 2002 358 citas

Unsafe and potentially safe herbal therapies. Meta-Analysis

American journal of … 1999 226 citas

Hair regrowth. Therapeutic agents. Review

Dermatologic clinics 1998 121 citas

Glucocorticoid- and mineralocorticoid receptors in microglial cells: the two receptors mediate differential effects of corticosteroids. Other

Glia 1997 232 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:: 8-18 mg/day
deficiency:: Per medical guidance based on ferritin levels

Límite superior: 45 mg/day (elemental iron)

Dosificaciones estudiadas en la investigación

Dosificación	Duración	Efecto	N
None	--	Mixed	--
None	--	Mixed	7014
None	--	Positive	--
None	--	Neutral	--
None	--	Positive	--
None	--	Mixed	--
Disease-modifying agents (tolvaptan, etc.)	--	Positive	--
None	--	Positive	--

Mejor momento para tomar: On empty stomach with vitamin C for best absorption; avoid with calcium, coffee, or tea

Safety & Side Effects

Efectos secundarios reportados

⚠ Constipation (most common)
⚠ Nausea and stomach cramps
⚠ Dark or black stools
⚠ Iron overload with excessive supplementation (hemochromatosis risk)

Interacciones conocidas

● Calcium supplements and dairy (reduce iron absorption by 50-60%)
● Proton pump inhibitors and H2 blockers (reduce absorption)
● Tetracycline and quinolone antibiotics (mutual absorption reduction)
● Levothyroxine (iron reduces thyroid hormone absorption)

Ingesta máxima tolerable: 45 mg/day (elemental iron)

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Iron help with Pediatric Immune Support?

Based on 5 studies with 400 participants, there is limited but promising evidence that Iron may support Pediatric Immune Support management. Our evidence grade is C (Some Evidence).

How much Iron should I take for Pediatric Immune Support?

Studies have used various dosages. A commonly studied range is 8-18 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Iron?

Reported side effects may include Constipation (most common), Nausea and stomach cramps, Dark or black stools, Iron overload with excessive supplementation (hemochromatosis risk). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Iron and Pediatric Immune Support?

We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Otros ingredientes para Pediatric Immune Support

Vitamin A B

Veredicto rápido

Evidence Strength52%

Moderate confidence

Desglose de estudios

RCT (3)Meta (4)Other (0)

Comparar alternativas

Vea cómo se comparan otros ingredientes para esta condición.

Ver todos los ingredientes para Pediatric Immune Support

Más información

References

[1] Zheng Xing et al.. Acta Biomater. 2025. Microenvironment-responsive recombinant collagen XVII-based composite microneedles for the treatment of androgenetic alopecia. doi:10.1016/j.actbio.2025.05.039 PubMed
[2] Yozahandy A Abarca et al.. Cureus. 2025. Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities. doi:10.7759/cureus.78298 PubMed
[3] Tiziana Galeazzi et al.. Nutrients. 2025. Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do? doi:10.3390/nu17091425 PubMed
[4] Xie Chengfeng et al.. Colloids Surf B Biointerfaces. 2025. Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis. doi:10.1016/j.colsurfb.2025.115035 PubMed
[5] Ana Melián-Olivera et al.. J Clin Med. 2025. Frontal Fibrosing Alopecia in Men: A Review of the Literature. doi:10.3390/jcm14061914 PubMed
[6] Xinyi Shao et al.. Nutr Rev. 2025. Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis. doi:10.1093/nutrit/nuaf015 PubMed
[7] Jiayang Zhang et al.. J Pineal Res. 2024. Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice. doi:10.1111/jpi.12964 PubMed
[8] Xuefei Zhang et al.. Int J Nanomedicine. 2024. Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies. doi:10.2147/IJN.S477820 PubMed
[9] Kitty St Pierre et al.. Cochrane Database Syst Rev. 2024. Interventions for preventing the progression of autosomal dominant polycystic kidney disease. doi:10.1002/14651858.CD010294.pub3 PubMed
[10] Sule Goksin. North Clin Istanb. 2022. Retrospective evaluation of clinical profile and comorbidities in patients with alopecia areata. doi:10.14744/nci.2022.78790 PubMed
[11] Cheng Zhou et al.. Clin Rev Allergy Immunol. 2021. Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management. doi:10.1007/s12016-021-08883-0 PubMed
[12] Eva Jover et al.. Biomedicines. 2021. Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike Protein. doi:10.3390/biomedicines9060639 PubMed
[13] Eva Hadadi et al.. Endocr Relat Cancer. 2021. Role of circadian rhythm disorders on EMT and tumour-immune interactions in endocrine-related cancers. doi:10.1530/ERC-20-0390 PubMed
[14] Olla A Khalifa et al.. BMC Vet Res. 2021. The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in … doi:10.1186/s12917-021-02963-1 PubMed
[15] Dimitrios T Papadimitriou et al.. World J Clin Pediatr. 2021. Treatment of alopecia totalis/universalis/focalis with vitamin D and analogs: Three case reports and a literature review. doi:10.5409/wjcp.v10.i6.192 PubMed
[16] Rasika Ranaweerage et al.. BMC Nephrol. 2021. Hypokalaemic paralysis and metabolic alkalosis in a patient with Sjögren syndrome: a case report and literature review. doi:10.1186/s12882-021-02371-5 PubMed
[17] M N Chang et al.. J Dairy Sci. 2020. Effects of different types of zinc supplement on the growth, incidence of diarrhea, immune function, and rectal microbiota of newborn … doi:10.3168/jds.2019-17610 PubMed
[18] Sandeep K Riar et al.. J Clin Sleep Med. 2019. Restless Legs Syndrome in Chronic Kidney Disease: Is Iron or Inflammatory Status To Blame? doi:10.5664/jcsm.8028 PubMed
[19] Aleksi J Hendricks et al.. Dermatitis. 2019. Clinical Pearls on Sleep Management in Atopic Dermatitis. doi:10.1097/DER.0000000000000523 PubMed
[20] Stergios A Polyzos et al.. Diabetes Obes Metab. 2017. Effects of combined low-dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non-invasive indices of steatosis and … doi:10.1111/dom.12989 PubMed
[21] Danuta Owczarek et al.. World J Gastroenterol. 2016. Diet and nutritional factors in inflammatory bowel diseases. doi:10.3748/wjg.v22.i3.895 PubMed
[22] Hans Wolff et al.. Dtsch Arztebl Int. 2016. The Diagnosis and Treatment of Hair and Scalp Diseases. doi:10.3238/arztebl.2016.0377 PubMed
[23] Wolfgang Kruis et al.. Dig Dis. 2016. Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? doi:10.1159/000443012 PubMed
[24] Gwang Seong Choi et al.. Ann Dermatol. 2016. Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia. doi:10.5021/ad.2016.28.4.444 PubMed
[25] Mariè van der Merwe et al.. J Sports Med (Hindawi Publ Corp). 2016. The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise. doi:10.1155/2016/7498359 PubMed
[26] Zhe Qu et al.. Neuromolecular Med. 2016. Protective Effects of AGE and Its Components on Neuroinflammation and Neurodegeneration. doi:10.1007/s12017-016-8410-1 PubMed
[27] Mahsa Salehi et al.. Cochrane Database Syst Rev. 2015. Interventions for central serous chorioretinopathy: a network meta-analysis. doi:10.1002/14651858.CD011841.pub2 PubMed
[28] H Wolff. Internist (Berl). 2015. [Drug treatment of alopecia]. doi:10.1007/s00108-015-3763-3 PubMed
[29] Robert E Click. J Immunol Methods. 2014. Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine. doi:10.1016/j.jim.2013.11.007 PubMed
[30] Priya Batra et al.. Int J Med Mushrooms. 2013. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. doi:10.1615/intjmedmushr.v15.i2.20 PubMed
[31] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
[32] Caroline Hwang et al.. Inflamm Bowel Dis. 2012. Micronutrient deficiencies in inflammatory bowel disease: from A to zinc. doi:10.1002/ibd.22906 PubMed
[33] Leonard B Weinstock et al.. Sleep Med Rev. 2012. Restless legs syndrome--theoretical roles of inflammatory and immune mechanisms. doi:10.1016/j.smrv.2011.09.003 PubMed
[34] Sonja Y Hess et al.. Food Nutr Bull. 2009. Effects of maternal zinc supplementation on pregnancy and lactation outcomes. doi:10.1177/15648265090301S105 PubMed
[35] Jen-Tzer Gau et al.. Pharmacoepidemiol Drug Saf. 2009. Uses of proton pump inhibitors and serum potassium levels. doi:10.1002/pds.1795 PubMed
[36] Courtney I Jarvis et al.. Ann Pharmacother. 2008. Management strategies for premenstrual syndrome/premenstrual dysphoric disorder. doi:10.1345/aph.1K673 PubMed
[37] Gisele Zandman-Goddard et al.. Isr Med Assoc J. 2008. Hyperferritinemia in autoimmunity. PubMed
[38] Rajiv Agarwal. Am J Nephrol. 2007. Nonhematological benefits of iron. doi:10.1159/000107927 PubMed
[39] Irene Kwan et al.. BMJ Clin Evid. 2007. Premenstrual syndrome. PubMed
[40] Yao Sun et al.. Cardiovasc Res. 2006. Oxidative stress in aldosteronism. doi:10.1016/j.cardiores.2006.03.007 PubMed
[41] Veronica Franco et al.. Clin Exp Pharmacol Physiol. 2006. Eplerenone prevents adverse cardiac remodelling induced by pressure overload in atrial natriuretic peptide-null mice. doi:10.1111/j.1440-1681.2006.04434.x PubMed
[42] Sabine Strassburg et al.. Heart Fail Rev. 2006. Metabolic and immunologic derangements in cardiac cachexia: where to from here? doi:10.1007/s10741-006-9193-5 PubMed
[43] Faith Claman et al.. J Pediatr Health Care. 2006. Premenstrual syndrome and premenstrual dysphoric disorder in adolescence. doi:10.1016/j.pedhc.2006.06.001 PubMed
[44] Philip C Calder et al.. Br J Nutr. 2002. The immune system: a target for functional foods? doi:10.1079/BJN2002682 PubMed
[45] T B Klepser et al.. Am J Health Syst Pharm. 1999. Unsafe and potentially safe herbal therapies. doi:10.1093/ajhp/56.2.125 PubMed
[46] J Shapiro et al.. Dermatol Clin. 1998. Hair regrowth. Therapeutic agents. doi:10.1016/s0733-8635(05)70017-6 PubMed
[47] J Tanaka et al.. Glia. 1997. Glucocorticoid- and mineralocorticoid receptors in microglial cells: the two receptors mediate differential effects of corticosteroids. PubMed

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.

Iron para Pediatric Immune Support

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Conclusión

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Dosificaciones de uso común

Dosificaciones estudiadas en la investigación

Safety & Side Effects

Efectos secundarios reportados

Interacciones conocidas

Frequently Asked Questions

Related Evidence

Otros ingredientes para Pediatric Immune Support

References