Iron для Pediatric Immune Support

C Доказательства Доказательства ограничены небольшими исследованиями, однако имеются некоторые положительные сигналы.

Iron supplementation in deficient children may help restore lymphocyte and neutrophil function. However, excess iron may feed pathogens and worsen infections. Supplementation should be guided by documented deficiency status.

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Итог

Key Study Findings

Review

Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities.

Dose: None или: None Outcome: None Эффект: None None

Популяция: None

Systematic Review and Meta-Analysis n=7014

Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis.

Dose: None или: Placebo Эффект: Standardized mean differences reported for each element and disease combination (specific values not None

In Vitro

Microenvironment-responsive recombinant collagen XVII-based composite microneedles for the treatment of androgenetic alopecia.

Dose: None или: Minoxidil Outcome: Hair regeneration in AGA mice Эффект: None None

Популяция: AGA mouse model

Review

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?

Dose: None или: None Outcome: Micronutrient deficiency management in pediatric IBD Эффект: None None

Популяция: Children with inflammatory bowel disease (review)

Other

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis.

Dose: None или: Uncoated EcN and UC model mice Outcome: UC inflammation and probiotic intestinal retention Эффект: None None

Популяция: Obese C57 mice with DSS-induced UC

Review

Frontal Fibrosing Alopecia in Men: A Review of the Literature.

Dose: None или: None Outcome: None Эффект: None None

Популяция: Review of frontal fibrosing alopecia in men

Key Statistics

Исследования

400

Участники

↑

Positive

Оценка

Referenced Papers

Microenvironment-responsive recombinant collagen XVII-based composite microneedles for the treatment of androgenetic alopecia. Other

Acta biomaterialia 2025 13 цитирований

Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities. Review

Cureus 2025 8 цитирований

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do? Review

Nutrients 2025 4 цитирований

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis. Other

Colloids and surfaces. … 2025 4 цитирований

Frontal Fibrosing Alopecia in Men: A Review of the Literature. Review

Journal of clinical … 2025 1 цитирований

Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis. Meta-Analysis

Nutrition reviews 2025

Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice. Other

Journal of pineal … 2024 9 цитирований

Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies. Other

International journal of … 2024 3 цитирований

Interventions for preventing the progression of autosomal dominant polycystic kidney disease. Systematic Review

The Cochrane database … 2024 1 цитирований

Retrospective evaluation of clinical profile and comorbidities in patients with alopecia areata. Other

Northern clinics of … 2022 7 цитирований

Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management. Review

Clinical reviews in … 2021 304 цитирований

Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike Protein. Other

Biomedicines 2021 27 цитирований

Role of circadian rhythm disorders on EMT and tumour-immune interactions in endocrine-related cancers. Review

Endocrine-related cancer 2021 26 цитирований

The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in … RCT

BMC veterinary research 2021 24 цитирований

Treatment of alopecia totalis/universalis/focalis with vitamin D and analogs: Three case reports and a literature review. Case Report

World journal of … 2021 10 цитирований

Hypokalaemic paralysis and metabolic alkalosis in a patient with Sjögren syndrome: a case report and literature review. Case Report

BMC nephrology 2021 2 цитирований

Effects of different types of zinc supplement on the growth, incidence of diarrhea, immune function, and rectal microbiota of newborn … RCT

Journal of dairy … 2020 58 цитирований

Restless Legs Syndrome in Chronic Kidney Disease: Is Iron or Inflammatory Status To Blame? Other

Journal of clinical … 2019 13 цитирований

Clinical Pearls on Sleep Management in Atopic Dermatitis. Review

Dermatitis : contact, … 2019 7 цитирований

Effects of combined low-dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non-invasive indices of steatosis and … RCT

Diabetes, obesity & … 2017 69 цитирований

Diet and nutritional factors in inflammatory bowel diseases. Review

World journal of … 2016 238 цитирований

The Diagnosis and Treatment of Hair and Scalp Diseases. Review

Deutsches Arzteblatt international 2016 99 цитирований

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? Review

Digestive diseases (Basel, … 2016 41 цитирований

Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia. Other

Annals of dermatology 2016 27 цитирований

The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise. Other

Journal of sports … 2016 13 цитирований

Protective Effects of AGE and Its Components on Neuroinflammation and Neurodegeneration. Other

Neuromolecular medicine 2016

Interventions for central serous chorioretinopathy: a network meta-analysis. Meta-Analysis

The Cochrane database … 2015 147 цитирований

[Drug treatment of alopecia]. Other

Der Internist 2015

Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine. Review

Journal of immunological … 2014 13 цитирований

Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Review

International journal of … 2013 104 цитирований

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 цитирований

Micronutrient deficiencies in inflammatory bowel disease: from A to zinc. Review

Inflammatory bowel diseases 2012 224 цитирований

Restless legs syndrome--theoretical roles of inflammatory and immune mechanisms. Review

Sleep medicine reviews 2012 139 цитирований

Effects of maternal zinc supplementation on pregnancy and lactation outcomes. Review

Food and nutrition … 2009 122 цитирований

Uses of proton pump inhibitors and serum potassium levels. Other

Pharmacoepidemiology and drug … 2009 22 цитирований

Management strategies for premenstrual syndrome/premenstrual dysphoric disorder. Meta-Analysis

The Annals of … 2008 82 цитирований

Hyperferritinemia in autoimmunity. Review

The Israel Medical … 2008 61 цитирований

Nonhematological benefits of iron. Review

American journal of … 2007 61 цитирований

Premenstrual syndrome. Systematic Review

BMJ clinical evidence 2007

Oxidative stress in aldosteronism. Review

Cardiovascular research 2006 42 цитирований

Eplerenone prevents adverse cardiac remodelling induced by pressure overload in atrial natriuretic peptide-null mice. Other

Clinical and experimental … 2006 22 цитирований

Metabolic and immunologic derangements in cardiac cachexia: where to from here? Review

Heart failure reviews 2006 22 цитирований

Premenstrual syndrome and premenstrual dysphoric disorder in adolescence. Review

Journal of pediatric … 2006 7 цитирований

The immune system: a target for functional foods? Review

The British journal … 2002 358 цитирований

Unsafe and potentially safe herbal therapies. Meta-Analysis

American journal of … 1999 226 цитирований

Hair regrowth. Therapeutic agents. Review

Dermatologic clinics 1998 121 цитирований

Glucocorticoid- and mineralocorticoid receptors in microglial cells: the two receptors mediate differential effects of corticosteroids. Other

Glia 1997 232 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:: 8-18 mg/day
deficiency:: Per medical guidance based on ferritin levels

Верхний предел: 45 mg/day (elemental iron)

Дозировки, изученные в исследованиях

Дозировка	Длительность	Эффект	N
None	--	Mixed	--
None	--	Mixed	7014
None	--	Positive	--
None	--	Neutral	--
None	--	Positive	--
None	--	Mixed	--
Disease-modifying agents (tolvaptan, etc.)	--	Positive	--
None	--	Positive	--

Лучшее время приёма: On empty stomach with vitamin C for best absorption; avoid with calcium, coffee, or tea

Safety & Side Effects

Зарегистрированные побочные эффекты

⚠ Constipation (most common)
⚠ Nausea and stomach cramps
⚠ Dark or black stools
⚠ Iron overload with excessive supplementation (hemochromatosis risk)

Известные взаимодействия

● Calcium supplements and dairy (reduce iron absorption by 50-60%)
● Proton pump inhibitors and H2 blockers (reduce absorption)
● Tetracycline and quinolone antibiotics (mutual absorption reduction)
● Levothyroxine (iron reduces thyroid hormone absorption)

Допустимый верхний уровень потребления: 45 mg/day (elemental iron)

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Iron help with Pediatric Immune Support?

Based on 5 studies with 400 participants, there is limited but promising evidence that Iron may support Pediatric Immune Support management. Our evidence grade is C (Some Evidence).

How much Iron should I take for Pediatric Immune Support?

Studies have used various dosages. A commonly studied range is 8-18 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Iron?

Reported side effects may include Constipation (most common), Nausea and stomach cramps, Dark or black stools, Iron overload with excessive supplementation (hemochromatosis risk). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Iron and Pediatric Immune Support?

We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Другие ингредиенты для Pediatric Immune Support

Vitamin A B

Краткий вывод

Evidence Strength52%

Moderate confidence

Разбор исследований

RCT (3)Meta (4)Other (0)

Сравнить альтернативы

Узнайте, как другие ингредиенты сравниваются при данном состоянии.

Посмотреть все ингредиенты для Pediatric Immune Support

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References

[1] Zheng Xing et al.. Acta Biomater. 2025. Microenvironment-responsive recombinant collagen XVII-based composite microneedles for the treatment of androgenetic alopecia. doi:10.1016/j.actbio.2025.05.039 PubMed
[2] Yozahandy A Abarca et al.. Cureus. 2025. Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities. doi:10.7759/cureus.78298 PubMed
[3] Tiziana Galeazzi et al.. Nutrients. 2025. Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do? doi:10.3390/nu17091425 PubMed
[4] Xie Chengfeng et al.. Colloids Surf B Biointerfaces. 2025. Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis. doi:10.1016/j.colsurfb.2025.115035 PubMed
[5] Ana Melián-Olivera et al.. J Clin Med. 2025. Frontal Fibrosing Alopecia in Men: A Review of the Literature. doi:10.3390/jcm14061914 PubMed
[6] Xinyi Shao et al.. Nutr Rev. 2025. Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis. doi:10.1093/nutrit/nuaf015 PubMed
[7] Jiayang Zhang et al.. J Pineal Res. 2024. Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice. doi:10.1111/jpi.12964 PubMed
[8] Xuefei Zhang et al.. Int J Nanomedicine. 2024. Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies. doi:10.2147/IJN.S477820 PubMed
[9] Kitty St Pierre et al.. Cochrane Database Syst Rev. 2024. Interventions for preventing the progression of autosomal dominant polycystic kidney disease. doi:10.1002/14651858.CD010294.pub3 PubMed
[10] Sule Goksin. North Clin Istanb. 2022. Retrospective evaluation of clinical profile and comorbidities in patients with alopecia areata. doi:10.14744/nci.2022.78790 PubMed
[11] Cheng Zhou et al.. Clin Rev Allergy Immunol. 2021. Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management. doi:10.1007/s12016-021-08883-0 PubMed
[12] Eva Jover et al.. Biomedicines. 2021. Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike Protein. doi:10.3390/biomedicines9060639 PubMed
[13] Eva Hadadi et al.. Endocr Relat Cancer. 2021. Role of circadian rhythm disorders on EMT and tumour-immune interactions in endocrine-related cancers. doi:10.1530/ERC-20-0390 PubMed
[14] Olla A Khalifa et al.. BMC Vet Res. 2021. The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in … doi:10.1186/s12917-021-02963-1 PubMed
[15] Dimitrios T Papadimitriou et al.. World J Clin Pediatr. 2021. Treatment of alopecia totalis/universalis/focalis with vitamin D and analogs: Three case reports and a literature review. doi:10.5409/wjcp.v10.i6.192 PubMed
[16] Rasika Ranaweerage et al.. BMC Nephrol. 2021. Hypokalaemic paralysis and metabolic alkalosis in a patient with Sjögren syndrome: a case report and literature review. doi:10.1186/s12882-021-02371-5 PubMed
[17] M N Chang et al.. J Dairy Sci. 2020. Effects of different types of zinc supplement on the growth, incidence of diarrhea, immune function, and rectal microbiota of newborn … doi:10.3168/jds.2019-17610 PubMed
[18] Sandeep K Riar et al.. J Clin Sleep Med. 2019. Restless Legs Syndrome in Chronic Kidney Disease: Is Iron or Inflammatory Status To Blame? doi:10.5664/jcsm.8028 PubMed
[19] Aleksi J Hendricks et al.. Dermatitis. 2019. Clinical Pearls on Sleep Management in Atopic Dermatitis. doi:10.1097/DER.0000000000000523 PubMed
[20] Stergios A Polyzos et al.. Diabetes Obes Metab. 2017. Effects of combined low-dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non-invasive indices of steatosis and … doi:10.1111/dom.12989 PubMed
[21] Danuta Owczarek et al.. World J Gastroenterol. 2016. Diet and nutritional factors in inflammatory bowel diseases. doi:10.3748/wjg.v22.i3.895 PubMed
[22] Hans Wolff et al.. Dtsch Arztebl Int. 2016. The Diagnosis and Treatment of Hair and Scalp Diseases. doi:10.3238/arztebl.2016.0377 PubMed
[23] Wolfgang Kruis et al.. Dig Dis. 2016. Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? doi:10.1159/000443012 PubMed
[24] Gwang Seong Choi et al.. Ann Dermatol. 2016. Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia. doi:10.5021/ad.2016.28.4.444 PubMed
[25] Mariè van der Merwe et al.. J Sports Med (Hindawi Publ Corp). 2016. The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise. doi:10.1155/2016/7498359 PubMed
[26] Zhe Qu et al.. Neuromolecular Med. 2016. Protective Effects of AGE and Its Components on Neuroinflammation and Neurodegeneration. doi:10.1007/s12017-016-8410-1 PubMed
[27] Mahsa Salehi et al.. Cochrane Database Syst Rev. 2015. Interventions for central serous chorioretinopathy: a network meta-analysis. doi:10.1002/14651858.CD011841.pub2 PubMed
[28] H Wolff. Internist (Berl). 2015. [Drug treatment of alopecia]. doi:10.1007/s00108-015-3763-3 PubMed
[29] Robert E Click. J Immunol Methods. 2014. Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine. doi:10.1016/j.jim.2013.11.007 PubMed
[30] Priya Batra et al.. Int J Med Mushrooms. 2013. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. doi:10.1615/intjmedmushr.v15.i2.20 PubMed
[31] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
[32] Caroline Hwang et al.. Inflamm Bowel Dis. 2012. Micronutrient deficiencies in inflammatory bowel disease: from A to zinc. doi:10.1002/ibd.22906 PubMed
[33] Leonard B Weinstock et al.. Sleep Med Rev. 2012. Restless legs syndrome--theoretical roles of inflammatory and immune mechanisms. doi:10.1016/j.smrv.2011.09.003 PubMed
[34] Sonja Y Hess et al.. Food Nutr Bull. 2009. Effects of maternal zinc supplementation on pregnancy and lactation outcomes. doi:10.1177/15648265090301S105 PubMed
[35] Jen-Tzer Gau et al.. Pharmacoepidemiol Drug Saf. 2009. Uses of proton pump inhibitors and serum potassium levels. doi:10.1002/pds.1795 PubMed
[36] Courtney I Jarvis et al.. Ann Pharmacother. 2008. Management strategies for premenstrual syndrome/premenstrual dysphoric disorder. doi:10.1345/aph.1K673 PubMed
[37] Gisele Zandman-Goddard et al.. Isr Med Assoc J. 2008. Hyperferritinemia in autoimmunity. PubMed
[38] Rajiv Agarwal. Am J Nephrol. 2007. Nonhematological benefits of iron. doi:10.1159/000107927 PubMed
[39] Irene Kwan et al.. BMJ Clin Evid. 2007. Premenstrual syndrome. PubMed
[40] Yao Sun et al.. Cardiovasc Res. 2006. Oxidative stress in aldosteronism. doi:10.1016/j.cardiores.2006.03.007 PubMed
[41] Veronica Franco et al.. Clin Exp Pharmacol Physiol. 2006. Eplerenone prevents adverse cardiac remodelling induced by pressure overload in atrial natriuretic peptide-null mice. doi:10.1111/j.1440-1681.2006.04434.x PubMed
[42] Sabine Strassburg et al.. Heart Fail Rev. 2006. Metabolic and immunologic derangements in cardiac cachexia: where to from here? doi:10.1007/s10741-006-9193-5 PubMed
[43] Faith Claman et al.. J Pediatr Health Care. 2006. Premenstrual syndrome and premenstrual dysphoric disorder in adolescence. doi:10.1016/j.pedhc.2006.06.001 PubMed
[44] Philip C Calder et al.. Br J Nutr. 2002. The immune system: a target for functional foods? doi:10.1079/BJN2002682 PubMed
[45] T B Klepser et al.. Am J Health Syst Pharm. 1999. Unsafe and potentially safe herbal therapies. doi:10.1093/ajhp/56.2.125 PubMed
[46] J Shapiro et al.. Dermatol Clin. 1998. Hair regrowth. Therapeutic agents. doi:10.1016/s0733-8635(05)70017-6 PubMed
[47] J Tanaka et al.. Glia. 1997. Glucocorticoid- and mineralocorticoid receptors in microglial cells: the two receptors mediate differential effects of corticosteroids. PubMed

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Iron для Pediatric Immune Support

Embed This Widget

Итог

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Часто используемые дозировки

Дозировки, изученные в исследованиях

Safety & Side Effects

Зарегистрированные побочные эффекты

Известные взаимодействия

Frequently Asked Questions

Related Evidence

Другие ингредиенты для Pediatric Immune Support

References