Iron ： Pediatric Immune Support

Iron supplementation in deficient children may help restore lymphocyte and neutrophil function. However, excess iron may feed pathogens and worsen infections. Supplementation should be guided by documented deficiency status.

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結論

Key Study Findings

Review

Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities.

Dose: None vs: None Outcome: None 効果: None None

対象集団: None

Systematic Review and Meta-Analysis n=7014

Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis.

Dose: None vs: Placebo 効果: Standardized mean differences reported for each element and disease combination (specific values not None

In Vitro

Microenvironment-responsive recombinant collagen XVII-based composite microneedles for the treatment of androgenetic alopecia.

Dose: None vs: Minoxidil Outcome: Hair regeneration in AGA mice 効果: None None

対象集団: AGA mouse model

Review

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?

Dose: None vs: None Outcome: Micronutrient deficiency management in pediatric IBD 効果: None None

対象集団: Children with inflammatory bowel disease (review)

Other

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis.

Dose: None vs: Uncoated EcN and UC model mice Outcome: UC inflammation and probiotic intestinal retention 効果: None None

対象集団: Obese C57 mice with DSS-induced UC

Review

Frontal Fibrosing Alopecia in Men: A Review of the Literature.

Dose: None vs: None Outcome: None 効果: None None

対象集団: Review of frontal fibrosing alopecia in men

Key Statistics

研究数

400

参加者数

↑

Positive

グレード

Referenced Papers

Microenvironment-responsive recombinant collagen XVII-based composite microneedles for the treatment of androgenetic alopecia. Other

Acta biomaterialia 2025 13 件の引用

Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities. Review

Cureus 2025 8 件の引用

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do? Review

Nutrients 2025 4 件の引用

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis. Other

Colloids and surfaces. … 2025 4 件の引用

Frontal Fibrosing Alopecia in Men: A Review of the Literature. Review

Journal of clinical … 2025 1 件の引用

Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis. Meta-Analysis

Nutrition reviews 2025

Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice. Other

Journal of pineal … 2024 9 件の引用

Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies. Other

International journal of … 2024 3 件の引用

Interventions for preventing the progression of autosomal dominant polycystic kidney disease. Systematic Review

The Cochrane database … 2024 1 件の引用

Retrospective evaluation of clinical profile and comorbidities in patients with alopecia areata. Other

Northern clinics of … 2022 7 件の引用

Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management. Review

Clinical reviews in … 2021 304 件の引用

Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike Protein. Other

Biomedicines 2021 27 件の引用

Role of circadian rhythm disorders on EMT and tumour-immune interactions in endocrine-related cancers. Review

Endocrine-related cancer 2021 26 件の引用

The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in … RCT

BMC veterinary research 2021 24 件の引用

Treatment of alopecia totalis/universalis/focalis with vitamin D and analogs: Three case reports and a literature review. Case Report

World journal of … 2021 10 件の引用

Hypokalaemic paralysis and metabolic alkalosis in a patient with Sjögren syndrome: a case report and literature review. Case Report

BMC nephrology 2021 2 件の引用

Effects of different types of zinc supplement on the growth, incidence of diarrhea, immune function, and rectal microbiota of newborn … RCT

Journal of dairy … 2020 58 件の引用

Restless Legs Syndrome in Chronic Kidney Disease: Is Iron or Inflammatory Status To Blame? Other

Journal of clinical … 2019 13 件の引用

Clinical Pearls on Sleep Management in Atopic Dermatitis. Review

Dermatitis : contact, … 2019 7 件の引用

Effects of combined low-dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non-invasive indices of steatosis and … RCT

Diabetes, obesity & … 2017 69 件の引用

Diet and nutritional factors in inflammatory bowel diseases. Review

World journal of … 2016 238 件の引用

The Diagnosis and Treatment of Hair and Scalp Diseases. Review

Deutsches Arzteblatt international 2016 99 件の引用

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? Review

Digestive diseases (Basel, … 2016 41 件の引用

Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia. Other

Annals of dermatology 2016 27 件の引用

The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise. Other

Journal of sports … 2016 13 件の引用

Protective Effects of AGE and Its Components on Neuroinflammation and Neurodegeneration. Other

Neuromolecular medicine 2016

Interventions for central serous chorioretinopathy: a network meta-analysis. Meta-Analysis

The Cochrane database … 2015 147 件の引用

[Drug treatment of alopecia]. Other

Der Internist 2015

Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine. Review

Journal of immunological … 2014 13 件の引用

Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Review

International journal of … 2013 104 件の引用

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 件の引用

Micronutrient deficiencies in inflammatory bowel disease: from A to zinc. Review

Inflammatory bowel diseases 2012 224 件の引用

Restless legs syndrome--theoretical roles of inflammatory and immune mechanisms. Review

Sleep medicine reviews 2012 139 件の引用

Effects of maternal zinc supplementation on pregnancy and lactation outcomes. Review

Food and nutrition … 2009 122 件の引用

Uses of proton pump inhibitors and serum potassium levels. Other

Pharmacoepidemiology and drug … 2009 22 件の引用

Management strategies for premenstrual syndrome/premenstrual dysphoric disorder. Meta-Analysis

The Annals of … 2008 82 件の引用

Hyperferritinemia in autoimmunity. Review

The Israel Medical … 2008 61 件の引用

Nonhematological benefits of iron. Review

American journal of … 2007 61 件の引用

Premenstrual syndrome. Systematic Review

BMJ clinical evidence 2007

Oxidative stress in aldosteronism. Review

Cardiovascular research 2006 42 件の引用

Eplerenone prevents adverse cardiac remodelling induced by pressure overload in atrial natriuretic peptide-null mice. Other

Clinical and experimental … 2006 22 件の引用

Metabolic and immunologic derangements in cardiac cachexia: where to from here? Review

Heart failure reviews 2006 22 件の引用

Premenstrual syndrome and premenstrual dysphoric disorder in adolescence. Review

Journal of pediatric … 2006 7 件の引用

The immune system: a target for functional foods? Review

The British journal … 2002 358 件の引用

Unsafe and potentially safe herbal therapies. Meta-Analysis

American journal of … 1999 226 件の引用

Hair regrowth. Therapeutic agents. Review

Dermatologic clinics 1998 121 件の引用

Glucocorticoid- and mineralocorticoid receptors in microglial cells: the two receptors mediate differential effects of corticosteroids. Other

Glia 1997 232 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 8-18 mg/day
deficiency:: Per medical guidance based on ferritin levels

上限量： 45 mg/day (elemental iron)

研究で検討された用量

用量	期間	効果	N
None	--	Mixed	--
None	--	Mixed	7014
None	--	Positive	--
None	--	Neutral	--
None	--	Positive	--
None	--	Mixed	--
Disease-modifying agents (tolvaptan, etc.)	--	Positive	--
None	--	Positive	--

推奨摂取タイミング： On empty stomach with vitamin C for best absorption; avoid with calcium, coffee, or tea

Safety & Side Effects

報告されている副作用

⚠ Constipation (most common)
⚠ Nausea and stomach cramps
⚠ Dark or black stools
⚠ Iron overload with excessive supplementation (hemochromatosis risk)

既知の相互作用

● Calcium supplements and dairy (reduce iron absorption by 50-60%)
● Proton pump inhibitors and H2 blockers (reduce absorption)
● Tetracycline and quinolone antibiotics (mutual absorption reduction)
● Levothyroxine (iron reduces thyroid hormone absorption)

耐容上限摂取量： 45 mg/day (elemental iron)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Iron help with Pediatric Immune Support?

Based on 5 studies with 400 participants, there is limited but promising evidence that Iron may support Pediatric Immune Support management. Our evidence grade is C (Some Evidence).

How much Iron should I take for Pediatric Immune Support?

Studies have used various dosages. A commonly studied range is 8-18 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Iron?

Reported side effects may include Constipation (most common), Nausea and stomach cramps, Dark or black stools, Iron overload with excessive supplementation (hemochromatosis risk). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Iron and Pediatric Immune Support?

We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Pediatric Immune Support

Vitamin A B

総合評価

Evidence Strength52%

Moderate confidence

研究の内訳

RCT (3)Meta (4)Other (0)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Pediatric Immune Support

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。