What is the recommended dosage for Pelargonium sidoides?

General: 30 drops (1.5 mL) liquid extract 3x/day or 20 mg EPs 7630 tablets 3x/day; Duration: 7-14 days

What are the side effects of Pelargonium sidoides?

Potential side effects include: Gastrointestinal discomfort (rare), Allergic skin reactions (rare), Nosebleeds (rare), Hepatotoxicity (very rare, case reports).

What is Pelargonium sidoides and how does it support immune health?

Pelargonium sidoides is a South African medicinal plant whose root extract (EPs 7630) has been clinically studied for acute upper respiratory infections, including bronchitis and the common cold. It may exert immunomodulatory and mild antibacterial effects.

What dosage of Pelargonium sidoides has been used in clinical trials?

The standardized extract EPs 7630 has been studied at doses of 30–90 mg per day in adults and 10–30 mg per day in children, typically for 5 to 10 days during acute respiratory infections. It is one of the better-studied herbal immune supplements.

What are the potential side effects of Pelargonium sidoides?

Common side effects include gastrointestinal complaints and occasional allergic skin reactions. Rare cases of liver injury have been reported in post-marketing surveillance. It may interact with anticoagulant medications.

Pelargonium sidoides

herb

Also known as: South African Geranium, Umckaloabo, EPs 7630

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About

Pelargonium sidoides (EPs 7630) is a South African plant extract approved as a medicine for respiratory infections in multiple countries. Its coumarins and gallic acid derivatives stimulate interferon production, enhance phagocytic activity, and modulate cytokine release with combined immunomodulatory, antibacterial, and antiviral properties.

How It Works

Root extract stimulates interferon production, enhances phagocytic activity, and modulates cytokine release; exhibits combined immunomodulatory, antibacterial, and antiviral properties through coumarins and gallic acid derivatives.

Evidence For Conditions

Condition	Grade	Studies	Participants
Acute Bronchitis	A	8	2000	View →

Side Effects

Gastrointestinal discomfort (rare)
Allergic skin reactions (rare)
Nosebleeds (rare)
Hepatotoxicity (very rare, case reports)

Drug & Supplement Interactions

Anticoagulants (theoretical increased bleeding risk due to coumarin content)
Immunosuppressant medications (may modulate immune function)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Andrographis Astragalus Echinacea Elderberry Garlic

Quick Facts

Dosage: General: 30 drops (1.5 mL) liquid extract 3x/day or 20 mg EPs 7630 tablets 3x/day; Duration: 7-14 days
Forms: liquid extract tablet
Natural Sources: South African native plant (supplement form only)
Upper Limit: No established UL
Best Time: At onset of respiratory symptoms; 3x daily for up to 14 days

Evidence Summary

Acute Bronchitis A

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.