Bifidobacterium lactis ： Immune Aging (Immunosenescence)

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Meta-analysis demonstrates short-term Bifidobacterium lactis supplementation may enhance NK cell activity and polymorphonuclear phagocytic capacity in healthy elderly adults. Supports balanced Th1/Th2 immune response in aging populations.

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結論

Key Study Findings

Other

Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization.

Dose: 12 g vs: None Outcome: None 効果: None None

対象集団: None

Randomized Controlled Trial n=27 3 weeks

Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related …

Dose: L. rhamnosus HN001 or B. lactis HN019 vs: Low fat milk (control) Outcome: NK cell activity and lymphocyte counts 効果: Enhanced NK cytotoxicity with both probiotics None

対象集団: Elderly subjects (63-84 years)

Key Statistics

研究数

300

参加者数

↑

Positive

グレード

Referenced Papers

Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization. Other

Journal of immunology … 2019 18 件の引用

Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes. CCT

Journal of clinical … 2001 337 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 1-10 billion CFU/day

上限量： No established UL

研究で検討された用量

用量	期間	効果	N
12 g	--	Mixed	--
L. rhamnosus HN001 or B. lactis HN019	3 weeks	Positive	27

推奨摂取タイミング： With meals or on empty stomach; consistent daily use

Safety & Side Effects

報告されている副作用

⚠ Mild bloating and gas (usually transient)
⚠ Generally very well tolerated

既知の相互作用

● Antibiotics (may reduce probiotic effectiveness; space doses 2+ hours apart)

耐容上限摂取量： No established UL

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Bifidobacterium lactis help with Immune Aging (Immunosenescence)?

Based on 5 studies with 300 participants, there is moderate evidence from clinical studies that Bifidobacterium lactis may support Immune Aging (Immunosenescence) management. Our evidence grade is B (Good Evidence).

How much Bifidobacterium lactis should I take for Immune Aging (Immunosenescence)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Bifidobacterium lactis?

Reported side effects may include Mild bloating and gas (usually transient), Generally very well tolerated. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Bifidobacterium lactis and Immune Aging (Immunosenescence)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

に関する他の成分： Immune Aging (Immunosenescence)

Vitamin D B Vitamin E B Reishi Mushroom C Turkey Tail Mushroom C Cordyceps C Maitake Mushroom C

総合評価

Evidence Strength72%

High confidence

研究の内訳

RCT (0)Meta (0)Other (5)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Immune Aging (Immunosenescence)

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References

[1] Da-Yong Zhang et al.. J Immunol Res. 2019. Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization. doi:10.1155/2019/4657928 PubMed
[2] H S Gill et al.. J Clin Immunol. 2001. Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes. doi:10.1023/a:1010979225018 PubMed

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