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Bifidobacterium lactis für Immune Aging (Immunosenescence)

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Meta-analysis demonstrates short-term Bifidobacterium lactis supplementation may enhance NK cell activity and polymorphonuclear phagocytic capacity in healthy elderly adults. Supports balanced Th1/Th2 immune response in aging populations.

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Meta-analysis demonstrates short-term Bifidobacterium lactis supplementation may enhance NK cell activity and polymorphonuclear phagocytic capacity in healthy elderly adults. Supports balanced Th1/Th2 immune response in aging populations.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Other
                
                
                
                
            

            
                Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization.
            
            

                
                Dose: 12 g
                
                
                vs.: None
                
                
                Outcome: None
                
                
                Wirkung: None
                
                
                None
                
            

            
            
Population: None

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=27
                
                
                3 weeks
                
                
            

            
                Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related …
            
            

                
                Dose: L. rhamnosus HN001 or B. lactis HN019
                
                
                vs.: Low fat milk (control)
                
                
                Outcome: NK cell activity and lymphocyte counts
                
                
                Wirkung: Enhanced NK cytotoxicity with both probiotics
                
                
                None
                
            

            
            
Population: Elderly subjects (63-84 years)

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
5

        
Studien

    

    

        
300

        
Teilnehmer

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
Bewertung

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of immunology …
                        2019
                        
                        18 Zitierungen
                        
                    

                

                
                

                    

                        
                            Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes.
                        
                        
                            
                                CCT
                            
                            
                            
                        
                    

                    

                        Journal of clinical …
                        2001
                        
                        337 Zitierungen
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Übliche Dosierungen

                

                    
                    

                        
general:

                        
1-10 billion CFU/day

                    

                    
                

                
                

                    Obergrenze: No established UL
                

                
            

            

            
            

                
In der Forschung untersuchte Dosierungen

                

                    

                        
                            

                                Dosierung
                                Dauer
                                Wirkung
                                N
                            

                        
                        
                            
                            

                                12 g
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                L. rhamnosus HN001 or B. lactis HN019
                                3 weeks
                                
                                    
                                    Positive
                                    
                                
                                27
                            

                            
                        
                    

                

            

            

            
            

                Beste Einnahmezeit: With meals or on empty stomach; consistent daily use
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Gemeldete Nebenwirkungen

                    
    
                        
                        
  • 
                            ⚠
                            Mild bloating and gas (usually transient)
                        
    • 
                        
                        
  • 
                            ⚠
                            Generally very well tolerated
                        
    • 
                        
                    

                

                

                
                

                    
Bekannte Wechselwirkungen

                    
    
                        
                        
  • 
                            ●
                            Antibiotics (may reduce probiotic effectiveness; space doses 2+ hours apart)
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerierbare Höchstaufnahmemenge: No established UL
                    

                

                
            

            

                Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Bifidobacterium lactis help with Immune Aging (Immunosenescence)?
            
        
        

            Based on 5 studies with 300 participants, there is moderate evidence from clinical studies that Bifidobacterium lactis may support Immune Aging (Immunosenescence) management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Bifidobacterium lactis should I take for Immune Aging (Immunosenescence)?
            
        
        

            Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Bifidobacterium lactis?
            
        
        

            Reported side effects may include Mild bloating and gas (usually transient), Generally very well tolerated. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Bifidobacterium lactis and Immune Aging (Immunosenescence)?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
            

        

        

    


    
    












    

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