Vitamin E ： Immune Aging (Immunosenescence)

Clinical trials in elderly populations demonstrate vitamin E supplementation at 200 IU/day may enhance delayed-type hypersensitivity (DTH) skin test response and antibody production. Recognized as one of the most effective single nutrients for modulating immune function in older adults.

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結論

Key Study Findings

Review

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?

Dose: None vs: None Outcome: Micronutrient deficiency management in pediatric IBD 効果: None None

対象集団: Children with inflammatory bowel disease (review)

Observational Study n=2065

Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE …

Dose: None vs: None Outcome: CMV IgG association with oxidative stress markers 効果: None None

対象集団: Age-stratified general population (MARK-AGE RASIG cohort)

In Vitro

Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction.

Dose: None vs: Untreated HFDPCs; finasteride, dutasteride, minoxidil Outcome: SRD5A1-3 and TGF-beta1 expression 効果: HFDPC proliferation 139.4+/-1.1% at 72h p<0.05

対象集団: Human hair follicle dermal papilla cells (in vitro)

Review

Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on …

Dose: None vs: None Outcome: None 効果: None None

対象集団: Elderly with immunosenescence

Other

The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels …

Dose: 100 mg vs: control Outcome: None 効果: or 1 None

対象集団: None

Review n=26282 988 weeks

Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES.

Dose: 45% vs: None Outcome: None 効果: None None

対象集団: None

Key Statistics

研究数

600

参加者数

↑

Positive

グレード

Referenced Papers

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do? Review

Nutrients 2025 4 件の引用

Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE population. Other

Biogerontology 2025

Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction. Other

Foods (Basel, Switzerland) 2025

Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota. Review

Advances in nutrition … 2022 1 件の引用

The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in … RCT

BMC veterinary research 2021 24 件の引用

Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES. Review

Nutrients 2020 75 件の引用

Vitamin C and vitamin C plus E improve the immune function in the elderly. Other

Experimental gerontology 2020 49 件の引用

Multifactorial immunodeficiency in frail elderly patients: Contributing factors and management. Review

Medecine et maladies … 2019 44 件の引用

Voluntary exercise reverses immune aging induced by oxidative stress in aging mice. Other

Experimental gerontology 2019 24 件の引用

Effects of combined low-dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non-invasive indices of steatosis and … RCT

Diabetes, obesity & … 2017 69 件の引用

Nutritional modulation of age-related changes in the immune system and risk of infection. Review

Nutrition research (New … 2017 67 件の引用

Comparison of AS03 and Alum on immune responses elicited by A/H3N2 split influenza vaccine in young, mature and aged BALB/c … Other

Vaccine 2016 27 件の引用

Role of vitamins in gastrointestinal diseases. Review

World journal of … 2015 62 件の引用

Age-associated changes in immune function: impact of vitamin E intervention and the underlying mechanisms. Review

Endocrine, metabolic & … 2014 84 件の引用

Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease. Other

Journal of pediatric … 2014 38 件の引用

Chemoprevention of prostate cancer. Review

Annual review of … 2014 9 件の引用

The role of nutrition in enhancing immunity in aging. Other

Aging and disease 2012 209 件の引用

Consumption of gold kiwifruit reduces severity and duration of selected upper respiratory tract infection symptoms and increases plasma vitamin C … RCT

The British journal … 2012 40 件の引用

The effect of age on the immune response of horses to vaccination. Other

Journal of comparative … 2010 17 件の引用

Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. Review

Journal of leukocyte … 2008 177 件の引用

The immune response to herpes simplex virus encephalitis in mice is modulated by dietary vitamin E. Other

The Journal of … 2008 34 件の引用

Role of redox imbalance in the molecular mechanisms responsible for immunosenescence. Other

Antioxidants & redox … 2003 26 件の引用

The immune system: a target for functional foods? Review

The British journal … 2002 358 件の引用

Enhancement of common mucosal immunity in aged mice following their supplementation with various antioxidants. Other

Vaccine 2000 35 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 15 mg/day (22.4 IU)
immunesupportelderly:: 200 IU/day

上限量： 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

研究で検討された用量

用量	期間	効果	N
None	--	Neutral	--
None	--	Negative	2065
None	--	Positive	--
None	--	Mixed	--
100 mg	--	Positive	--
45%	988 weeks	Positive	26282
500 mg	12 weeks	Mixed	--
None	--	Mixed	--

推奨摂取タイミング： With meals containing fat

Safety & Side Effects

報告されている副作用

⚠ Increased bleeding risk at high doses (>400 IU/day)
⚠ Nausea and gastrointestinal distress
⚠ Fatigue and muscle weakness at very high doses
⚠ Potential increased mortality risk at chronic high doses (meta-analysis finding, debated)

既知の相互作用

● Anticoagulants and antiplatelet drugs (increased bleeding risk)
● Statins (may reduce statin effectiveness)
● Chemotherapy agents (may interfere with oxidative mechanisms)
● Vitamin K (high-dose vitamin E may antagonize vitamin K)

耐容上限摂取量： 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Vitamin E help with Immune Aging (Immunosenescence)?

Based on 5 studies with 600 participants, there is moderate evidence from clinical studies that Vitamin E may support Immune Aging (Immunosenescence) management. Our evidence grade is B (Good Evidence).

How much Vitamin E should I take for Immune Aging (Immunosenescence)?

Studies have used various dosages. A commonly studied range is 15 mg/day (22.4 IU). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin E?

Reported side effects may include Increased bleeding risk at high doses (>400 IU/day), Nausea and gastrointestinal distress, Fatigue and muscle weakness at very high doses, Potential increased mortality risk at chronic high doses (meta-analysis finding, debated). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin E and Immune Aging (Immunosenescence)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Immune Aging (Immunosenescence)

Vitamin D B Bifidobacterium lactis B Reishi Mushroom C Turkey Tail Mushroom C Cordyceps C Maitake Mushroom C

総合評価

Evidence Strength72%

High confidence

研究の内訳

RCT (3)Meta (0)Other (2)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Immune Aging (Immunosenescence)

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FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。