Vitamin E ： Immune Aging (Immunosenescence)
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。Clinical trials in elderly populations demonstrate vitamin E supplementation at 200 IU/day may enhance delayed-type hypersensitivity (DTH) skin test response and antibody production. Recognized as one of the most effective single nutrients for modulating immune function in older adults.
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B
結論
Clinical trials in elderly populations demonstrate vitamin E supplementation at 200 IU/day may enhance delayed-type hypersensitivity (DTH) skin test response and antibody production. Recognized as one of the most effective single nutrients for modulating immune function in older adults.
Key Study Findings
Review
Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?
Dose: None
vs: None
Outcome: Micronutrient deficiency management in pediatric IBD
効果: None
None
対象集団: Children with inflammatory bowel disease (review)
Observational Study
n=2065
Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE …
Dose: None
vs: None
Outcome: CMV IgG association with oxidative stress markers
効果: None
None
対象集団: Age-stratified general population (MARK-AGE RASIG cohort)
In Vitro
Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction.
Dose: None
vs: Untreated HFDPCs; finasteride, dutasteride, minoxidil
Outcome: SRD5A1-3 and TGF-beta1 expression
効果: HFDPC proliferation 139.4+/-1.1% at 72h
p<0.05
対象集団: Human hair follicle dermal papilla cells (in vitro)
Review
Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Elderly with immunosenescence
Other
The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels …
Dose: 100 mg
vs: control
Outcome: None
効果: or 1
None
対象集団: None
Review
n=26282
988 weeks
Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES.
Dose: 45%
vs: None
Outcome: None
効果: None
None
対象集団: None
Key Statistics
5
研究数
600
参加者数
↑
Positive
B
グレード
Referenced Papers
Nutrients
2025
4 件の引用
Biogerontology
2025
Foods (Basel, Switzerland)
2025
Advances in nutrition …
2022
1 件の引用
BMC veterinary research
2021
24 件の引用
Nutrients
2020
75 件の引用
Experimental gerontology
2020
49 件の引用
Multifactorial immunodeficiency in frail elderly patients: Contributing factors and management.
Review
Medecine et maladies …
2019
44 件の引用
Experimental gerontology
2019
24 件の引用
Diabetes, obesity & …
2017
69 件の引用
Nutrition research (New …
2017
67 件の引用
Vaccine
2016
27 件の引用
World journal of …
2015
62 件の引用
Endocrine, metabolic & …
2014
84 件の引用
Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease.
Other
Journal of pediatric …
2014
38 件の引用
Annual review of …
2014
9 件の引用
Aging and disease
2012
209 件の引用
The British journal …
2012
40 件の引用
Journal of comparative …
2010
17 件の引用
Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention.
Review
Journal of leukocyte …
2008
177 件の引用
The immune response to herpes simplex virus encephalitis in mice is modulated by dietary vitamin E.
Other
The Journal of …
2008
34 件の引用
Antioxidants & redox …
2003
26 件の引用
The British journal …
2002
358 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 15 mg/day (22.4 IU)
- immunesupportelderly:
- 200 IU/day
上限量： 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Neutral | -- |
| None | -- | Negative | 2065 |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| 100 mg | -- | Positive | -- |
| 45% | 988 weeks | Positive | 26282 |
| 500 mg | 12 weeks | Mixed | -- |
| None | -- | Mixed | -- |
推奨摂取タイミング： With meals containing fat
Safety & Side Effects
報告されている副作用
- ⚠ Increased bleeding risk at high doses (>400 IU/day)
- ⚠ Nausea and gastrointestinal distress
- ⚠ Fatigue and muscle weakness at very high doses
- ⚠ Potential increased mortality risk at chronic high doses (meta-analysis finding, debated)
既知の相互作用
- ● Anticoagulants and antiplatelet drugs (increased bleeding risk)
- ● Statins (may reduce statin effectiveness)
- ● Chemotherapy agents (may interfere with oxidative mechanisms)
- ● Vitamin K (high-dose vitamin E may antagonize vitamin K)
耐容上限摂取量： 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Vitamin E help with Immune Aging (Immunosenescence)?
Based on 5 studies with 600 participants, there is moderate evidence from clinical studies that Vitamin E may support Immune Aging (Immunosenescence) management. Our evidence grade is B (Good Evidence).
How much Vitamin E should I take for Immune Aging (Immunosenescence)?
Studies have used various dosages. A commonly studied range is 15 mg/day (22.4 IU). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin E?
Reported side effects may include Increased bleeding risk at high doses (>400 IU/day), Nausea and gastrointestinal distress, Fatigue and muscle weakness at very high doses, Potential increased mortality risk at chronic high doses (meta-analysis finding, debated). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin E and Immune Aging (Immunosenescence)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Immune Aging (Immunosenescence)
References
- [1] Tiziana Galeazzi et al.. Nutrients. 2025. Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do? doi:10.3390/nu17091425 PubMed
- [2] Laura Cianfruglia et al.. Biogerontology. 2025. Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE population. doi:10.1007/s10522-025-10288-x PubMed
- [3] Anurak Muangsanguan et al.. Foods. 2025. Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction. doi:10.3390/foods14152583 PubMed
- [4] Philip C Calder et al.. Adv Nutr. 2022. Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota. doi:10.1093/advances/nmac052 PubMed
- [5] Olla A Khalifa et al.. BMC Vet Res. 2021. The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in … doi:10.1186/s12917-021-02963-1 PubMed
- [6] Carroll A Reider et al.. Nutrients. 2020. Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES. doi:10.3390/nu12061735 PubMed
- [7] Mónica De la Fuente et al.. Exp Gerontol. 2020. Vitamin C and vitamin C plus E improve the immune function in the elderly. doi:10.1016/j.exger.2020.111118 PubMed
- [8] T Tannou et al.. Med Mal Infect. 2019. Multifactorial immunodeficiency in frail elderly patients: Contributing factors and management. doi:10.1016/j.medmal.2019.01.012 PubMed
- [9] Ji-Young Lee et al.. Exp Gerontol. 2019. Voluntary exercise reverses immune aging induced by oxidative stress in aging mice. doi:10.1016/j.exger.2018.08.009 PubMed
- [10] Stergios A Polyzos et al.. Diabetes Obes Metab. 2017. Effects of combined low-dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non-invasive indices of steatosis and … doi:10.1111/dom.12989 PubMed
- [11] Munkyong Pae et al.. Nutr Res. 2017. Nutritional modulation of age-related changes in the immune system and risk of infection. doi:10.1016/j.nutres.2017.02.001 PubMed
- [12] Karen K Yam et al.. Vaccine. 2016. Comparison of AS03 and Alum on immune responses elicited by A/H3N2 split influenza vaccine in young, mature and aged BALB/c … doi:10.1016/j.vaccine.2016.02.012 PubMed
- [13] Omar A Masri et al.. World J Gastroenterol. 2015. Role of vitamins in gastrointestinal diseases. doi:10.3748/wjg.v21.i17.5191 PubMed
- [14] Dayong Wu et al.. Endocr Metab Immune Disord Drug Targets. 2014. Age-associated changes in immune function: impact of vitamin E intervention and the underlying mechanisms. doi:10.2174/1871530314666140922143950 PubMed
- [15] Neha R Santucci et al.. J Pediatr Gastroenterol Nutr. 2014. Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease. doi:10.1097/MPG.0000000000000477 PubMed
- [16] Goutham Vemana et al.. Annu Rev Med. 2014. Chemoprevention of prostate cancer. doi:10.1146/annurev-med-121211-091759 PubMed
- [17] Munkyong Pae et al.. Aging Dis. 2012. The role of nutrition in enhancing immunity in aging. PubMed
- [18] Denise C Hunter et al.. Br J Nutr. 2012. Consumption of gold kiwifruit reduces severity and duration of selected upper respiratory tract infection symptoms and increases plasma vitamin C … doi:10.1017/S0007114511006659 PubMed
- [19] T L Muirhead et al.. J Comp Pathol. 2010. The effect of age on the immune response of horses to vaccination. doi:10.1016/j.jcpa.2009.10.010 PubMed
- [20] Dayong Wu et al.. J Leukoc Biol. 2008. Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. doi:10.1189/jlb.0108023 PubMed
- [21] Patricia A Sheridan et al.. J Nutr. 2008. The immune response to herpes simplex virus encephalitis in mice is modulated by dietary vitamin E. doi:10.1093/jn/138.1.130 PubMed
- [22] Raymond A Daynes et al.. Antioxid Redox Signal. 2003. Role of redox imbalance in the molecular mechanisms responsible for immunosenescence. doi:10.1089/152308603770310185 PubMed
- [23] Philip C Calder et al.. Br J Nutr. 2002. The immune system: a target for functional foods? doi:10.1079/BJN2002682 PubMed
- [24] E Y Enioutina et al.. Vaccine. 2000. Enhancement of common mucosal immunity in aged mice following their supplementation with various antioxidants. doi:10.1016/s0264-410x(00)00008-6 PubMed
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