Vitamin E 用于 Immune Aging (Immunosenescence)

Clinical trials in elderly populations demonstrate vitamin E supplementation at 200 IU/day may enhance delayed-type hypersensitivity (DTH) skin test response and antibody production. Recognized as one of the most effective single nutrients for modulating immune function in older adults.

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结论

Key Study Findings

Review

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?

Dose: None vs: None Outcome: Micronutrient deficiency management in pediatric IBD 效果: None None

研究人群: Children with inflammatory bowel disease (review)

Observational Study n=2065

Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE …

Dose: None vs: None Outcome: CMV IgG association with oxidative stress markers 效果: None None

研究人群: Age-stratified general population (MARK-AGE RASIG cohort)

In Vitro

Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction.

Dose: None vs: Untreated HFDPCs; finasteride, dutasteride, minoxidil Outcome: SRD5A1-3 and TGF-beta1 expression 效果: HFDPC proliferation 139.4+/-1.1% at 72h p<0.05

研究人群: Human hair follicle dermal papilla cells (in vitro)

Review

Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on …

Dose: None vs: None Outcome: None 效果: None None

研究人群: Elderly with immunosenescence

Other

The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels …

Dose: 100 mg vs: control Outcome: None 效果: or 1 None

研究人群: None

Review n=26282 988 weeks

Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES.

Dose: 45% vs: None Outcome: None 效果: None None

研究人群: None

Key Statistics

研究数量

600

受试者

↑

Positive

等级

Referenced Papers

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do? Review

Nutrients 2025 4 次引用

Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE population. Other

Biogerontology 2025

Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction. Other

Foods (Basel, Switzerland) 2025

Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota. Review

Advances in nutrition … 2022 1 次引用

The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in … RCT

BMC veterinary research 2021 24 次引用

Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES. Review

Nutrients 2020 75 次引用

Vitamin C and vitamin C plus E improve the immune function in the elderly. Other

Experimental gerontology 2020 49 次引用

Multifactorial immunodeficiency in frail elderly patients: Contributing factors and management. Review

Medecine et maladies … 2019 44 次引用

Voluntary exercise reverses immune aging induced by oxidative stress in aging mice. Other

Experimental gerontology 2019 24 次引用

Effects of combined low-dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non-invasive indices of steatosis and … RCT

Diabetes, obesity & … 2017 69 次引用

Nutritional modulation of age-related changes in the immune system and risk of infection. Review

Nutrition research (New … 2017 67 次引用

Comparison of AS03 and Alum on immune responses elicited by A/H3N2 split influenza vaccine in young, mature and aged BALB/c … Other

Vaccine 2016 27 次引用

Role of vitamins in gastrointestinal diseases. Review

World journal of … 2015 62 次引用

Age-associated changes in immune function: impact of vitamin E intervention and the underlying mechanisms. Review

Endocrine, metabolic & … 2014 84 次引用

Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease. Other

Journal of pediatric … 2014 38 次引用

Chemoprevention of prostate cancer. Review

Annual review of … 2014 9 次引用

The role of nutrition in enhancing immunity in aging. Other

Aging and disease 2012 209 次引用

Consumption of gold kiwifruit reduces severity and duration of selected upper respiratory tract infection symptoms and increases plasma vitamin C … RCT

The British journal … 2012 40 次引用

The effect of age on the immune response of horses to vaccination. Other

Journal of comparative … 2010 17 次引用

Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. Review

Journal of leukocyte … 2008 177 次引用

The immune response to herpes simplex virus encephalitis in mice is modulated by dietary vitamin E. Other

The Journal of … 2008 34 次引用

Role of redox imbalance in the molecular mechanisms responsible for immunosenescence. Other

Antioxidants & redox … 2003 26 次引用

The immune system: a target for functional foods? Review

The British journal … 2002 358 次引用

Enhancement of common mucosal immunity in aged mice following their supplementation with various antioxidants. Other

Vaccine 2000 35 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 15 mg/day (22.4 IU)
immunesupportelderly:: 200 IU/day

上限： 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Neutral	--
None	--	Negative	2065
None	--	Positive	--
None	--	Mixed	--
100 mg	--	Positive	--
45%	988 weeks	Positive	26282
500 mg	12 weeks	Mixed	--
None	--	Mixed	--

最佳服用时间： With meals containing fat

Safety & Side Effects

已报告的副作用

⚠ Increased bleeding risk at high doses (>400 IU/day)
⚠ Nausea and gastrointestinal distress
⚠ Fatigue and muscle weakness at very high doses
⚠ Potential increased mortality risk at chronic high doses (meta-analysis finding, debated)

已知相互作用

● Anticoagulants and antiplatelet drugs (increased bleeding risk)
● Statins (may reduce statin effectiveness)
● Chemotherapy agents (may interfere with oxidative mechanisms)
● Vitamin K (high-dose vitamin E may antagonize vitamin K)

可耐受最高摄入量： 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Vitamin E help with Immune Aging (Immunosenescence)?

Based on 5 studies with 600 participants, there is moderate evidence from clinical studies that Vitamin E may support Immune Aging (Immunosenescence) management. Our evidence grade is B (Good Evidence).

How much Vitamin E should I take for Immune Aging (Immunosenescence)?

Studies have used various dosages. A commonly studied range is 15 mg/day (22.4 IU). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin E?

Reported side effects may include Increased bleeding risk at high doses (>400 IU/day), Nausea and gastrointestinal distress, Fatigue and muscle weakness at very high doses, Potential increased mortality risk at chronic high doses (meta-analysis finding, debated). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin E and Immune Aging (Immunosenescence)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于 Immune Aging (Immunosenescence)

Vitamin D B Bifidobacterium lactis B Reishi Mushroom C Turkey Tail Mushroom C Cordyceps C Maitake Mushroom C

快速结论

Evidence Strength72%

High confidence

研究分析

RCT (3)Meta (0)Other (2)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于 Immune Aging (Immunosenescence)

了解更多

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