Conjugated Linoleic Acid لـ Chronic Inflammation
D الأبحاث توجد أبحاث أولية فحسب (دراسات مختبرية، تقارير حالات).Animal studies show CLA may have immunomodulatory effects via PPAR-gamma activation. Human evidence for immune-specific outcomes is limited and inconsistent, with some studies showing no significant benefit.
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D
الخلاصة
Animal studies show CLA may have immunomodulatory effects via PPAR-gamma activation. Human evidence for immune-specific outcomes is limited and inconsistent, with some studies showing no significant benefit.
Key Study Findings
Review
A perspective on the chemical structures and molecular mechanisms of curcumin and its derivatives and …
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: Review of curcumin derivatives in cancer treatment
Review
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: review of dietary polyphenols in type 2 diabetes mellitus management
Review
Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects …
Dose: None
مقابل: None
Outcome: Musculoskeletal aging and cellular senescence
التأثير: None
None
المجتمع المدروس: Aging adults with musculoskeletal decline (review)
Review
Retracted: Chronic Epipharyngitis Treated with Epipharyngeal Abrasion Therapy: Symptoms, Diagnosis, Pathogenesis, and Treatment Outcomes.
Dose: 1% zinc chloride solution
مقابل: None
Outcome: Chronic epipharyngitis symptom improvement
التأثير: None
None
المجتمع المدروس: Patients with chronic epipharyngitis (retracted publication)
Systematic Review
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: Review of TCM compounds in autoimmune skin diseases
Other
The omega effect: Harnessing fish oil for health.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
Key Statistics
3
الدراسات
150
المشاركون
↔
Mixed
D
التقييم
Referenced Papers
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Review
Nutrients
2025
32 اقتباسات
International journal of …
2025
5 اقتباسات
International journal of …
2025
2 اقتباسات
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Systematic Review
Frontiers in immunology
2025
1 اقتباسات
Atherosclerosis
2025
JMA journal
2025
Journal of clinical …
2024
29 اقتباسات
Molecular nutrition & …
2024
15 اقتباسات
Newborn (Clarksville, Md.)
2024
9 اقتباسات
Nutrients
2024
7 اقتباسات
Advances in rheumatology …
2024
Current molecular pharmacology
2023
72 اقتباسات
Immunological investigations
2023
13 اقتباسات
International immunopharmacology
2023
8 اقتباسات
International journal of …
2022
26 اقتباسات
Effect of omega-3 fatty acids on the telomere length: A mini meta-analysis of clinical trials.
Meta-Analysis
Biomolecular concepts
2022
18 اقتباسات
Foods (Basel, Switzerland)
2022
9 اقتباسات
Nutrients
2021
36 اقتباسات
Frontiers in medicine
2021
6 اقتباسات
Naunyn-Schmiedeberg's archives of …
2020
37 اقتباسات
Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis.
Other
Toxicology mechanisms and …
2019
33 اقتباسات
Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids.
RCT
Prostaglandins, leukotrienes, and …
2018
38 اقتباسات
MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol.
Review
Medicines (Basel, Switzerland)
2018
23 اقتباسات
Current pharmaceutical design
2017
168 اقتباسات
Lipids
2017
21 اقتباسات
BMC medicine
2015
230 اقتباسات
Blood cells, molecules …
2015
53 اقتباسات
Lipids
2012
28 اقتباسات
The Journal of …
2010
32 اقتباسات
Lipids in health …
2010
7 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 1.5-3 g/day
الحد الأعلى: No established UL
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 1% zinc chloride solution | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 200 mg | 5 weeks | Positive | -- |
| None | -- | Positive | -- |
أفضل وقت للتناول: With meals
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Fatigue
- ⚠ May worsen insulin sensitivity in some individuals
- ⚠ Liver fat accumulation (some formulations)
التفاعلات المعروفة
- ● Diabetes medications (may affect insulin sensitivity)
- ● Anticoagulants (may have additive effects)
الحد الأقصى المسموح به: No established UL
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Conjugated Linoleic Acid help with Chronic Inflammation?
Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that Conjugated Linoleic Acid may support Chronic Inflammation management. Our evidence grade is D (Very Early Research).
How much Conjugated Linoleic Acid should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 1.5-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Conjugated Linoleic Acid?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Fatigue, May worsen insulin sensitivity in some individuals, Liver fat accumulation (some formulations). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Conjugated Linoleic Acid and Chronic Inflammation?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.
Related Evidence
مكونات أخرى لـ Chronic Inflammation
References
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- [2] Angela Falvino et al.. Int J Mol Sci. 2025. Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of Exercise. doi:10.3390/ijms26157573 PubMed
- [3] Lujie Zhu et al.. Int J Oncol. 2025. A perspective on the chemical structures and molecular mechanisms of curcumin and its derivatives and analogs in cancer treatment (Review). doi:10.3892/ijo.2025.5782 PubMed
- [4] Yuhan Wang et al.. Front Immunol. 2025. Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases. doi:10.3389/fimmu.2025.1629288 PubMed
- [5] Jacques D Barth. Atherosclerosis. 2025. The omega effect: Harnessing fish oil for health. doi:10.1016/j.atherosclerosis.2025.120461 PubMed
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- [7] Houriah Yasir Nukaly et al.. J Clin Med. 2024. Oral Lichen Planus: A Narrative Review Navigating Etiologies, Clinical Manifestations, Diagnostics, and Therapeutic Approaches. doi:10.3390/jcm13175280 PubMed
- [8] Qi Sun et al.. Mol Nutr Food Res. 2024. Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis Mice. doi:10.1002/mnfr.202300446 PubMed
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- [16] Sawan Ali et al.. Biomol Concepts. 2022. Effect of omega-3 fatty acids on the telomere length: A mini meta-analysis of clinical trials. doi:10.1515/bmc-2021-0024 PubMed
- [17] Monica Tognocchi et al.. Foods. 2022. Supplementation of Enriched Polyunsaturated Fatty Acids and CLA Cheese on High Fat Diet: Effects on Lipid Metabolism and Fat Profile. doi:10.3390/foods11030398 PubMed
- [18] Rosaria Varì et al.. Nutrients. 2021. Obesity-Associated Inflammation: Does Curcumin Exert a Beneficial Role? doi:10.3390/nu13031021 PubMed
- [19] Sanja Lalic-Cosic et al.. Front Med (Lausanne). 2021. Phosphatidylserine Exposing Extracellular Vesicles in Pre-eclamptic Patients. doi:10.3389/fmed.2021.761453 PubMed
- [20] Yuxin Xian et al.. Naunyn Schmiedebergs Arch Pharmacol. 2020. Resveratrol prevents diabetic nephropathy by reducing chronic inflammation and improving the blood glucose memory effect in non-obese diabetic mice. doi:10.1007/s00210-019-01777-1 PubMed
- [21] Mohita Sharma et al.. Toxicol Mech Methods. 2019. Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis. doi:10.1080/15376516.2018.1553220 PubMed
- [22] Gregory C Shearer et al.. Prostaglandins Leukot Essent Fatty Acids. 2018. Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids. doi:10.1016/j.plefa.2017.10.006 PubMed
- [23] Jean-Jacques Michaille et al.. Medicines (Basel). 2018. MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol. doi:10.3390/medicines5030074 PubMed
- [24] Morteza Ghandadi et al.. Curr Pharm Des. 2017. Curcumin: An Effective Inhibitor of Interleukin-6. doi:10.2174/1381612822666161006151605 PubMed
- [25] Jake M Olson et al.. Lipids. 2017. A Comparison of the Anti-Inflammatory Effects of Cis-9, Trans-11 Conjugated Linoleic Acid to Celecoxib in the Collagen-Induced Arthritis Model. doi:10.1007/s11745-016-4228-8 PubMed
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- [28] Meaghan Reardon et al.. Lipids. 2012. Oleic acid attenuates trans-10,cis-12 conjugated linoleic acid-mediated inflammatory gene expression in human adipocytes. doi:10.1007/s11745-012-3711-0 PubMed
- [29] Shane M Huebner et al.. J Nutr. 2010. Individual isomers of conjugated linoleic acid reduce inflammation associated with established collagen-induced arthritis in DBA/1 mice. doi:10.3945/jn.109.120527 PubMed
- [30] Aurelio Ocaña et al.. Lipids Health Dis. 2010. In vitro study of the effect of diesterified alkoxyglycerols with conjugated linoleic acid on adipocyte inflammatory mediators. doi:10.1186/1476-511X-9-36 PubMed
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