Resveratrol لـ Chronic Inflammation
C الأدلة أدلة محدودة من دراسات صغيرة، غير أن ثمة بعض الإشارات الإيجابية.Preclinical models demonstrate immunomodulatory and anti-inflammatory effects through SIRT1 and NF-kB modulation. Human trials show reduction in CRP and other inflammatory markers, though low oral bioavailability remains a key limitation.
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C
الخلاصة
Preclinical models demonstrate immunomodulatory and anti-inflammatory effects through SIRT1 and NF-kB modulation. Human trials show reduction in CRP and other inflammatory markers, though low oral bioavailability remains a key limitation.
Key Study Findings
Review
Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
Review
Modulating Ferroptosis in Aging: The Therapeutic Potential of Natural Products.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
Review
Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer's Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty …
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
Review
Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovascular Drugs and Future Directions.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
In Vitro
Resveratrol derivative SH-707 inhibits NLRP3 inflammasome activation via a sirtuin 1-dependent pathway.
Dose: None
مقابل: LPS-induced septic mouse model vs control
Outcome: IL-1β secretion and NLRP3 inflammasome activation
التأثير: None
None
المجتمع المدروس: Macrophages and LPS-induced septic mouse model
Other
Gut microbiota-metabolite crosstalk mediates icariin's protection against obesity-induced spermatogenic dysfunction through NF-κB/AMH axis in Sertoli …
Dose: None
مقابل: HFD mouse model vs control
Outcome: Testicular morphology and spermatogenesis markers
التأثير: None
None
المجتمع المدروس: HFD-induced obese mouse model (spermatogenesis)
Key Statistics
5
الدراسات
300
المشاركون
↑
Positive
C
التقييم
Referenced Papers
ESC heart failure
2025
58 اقتباسات
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Review
Nutrients
2025
32 اقتباسات
Nutrients
2025
32 اقتباسات
International journal of …
2025
32 اقتباسات
Pathology, research and …
2025
26 اقتباسات
Immunity & ageing …
2025
25 اقتباسات
Molecular neurobiology
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Nutrients
2025
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Journal of aging …
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Biomedicines
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5 اقتباسات
Current issues in …
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5 اقتباسات
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Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Systematic Review
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1 اقتباسات
Phytomedicine : international …
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1 اقتباسات
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2024
27 اقتباسات
Journal of hazardous …
2024
20 اقتباسات
Journal of ovarian …
2024
13 اقتباسات
Antitumor Effects of Resveratrol Opposing Mechanisms of Helicobacter pylori in Gastric Cancer.
Review
Nutrients
2024
12 اقتباسات
Biology of reproduction
2024
9 اقتباسات
Oncology research
2024
8 اقتباسات
International journal of …
2024
3 اقتباسات
Zhonghua wei zhong …
2024
1 اقتباسات
Voprosy pitaniia
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19 اقتباسات
Cancer investigation
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6 اقتباسات
Complementary therapies in …
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115 اقتباسات
Nutrition research (New …
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Nutrients
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26 اقتباسات
The Journal of …
2021
117 اقتباسات
International journal of …
2021
20 اقتباسات
Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease.
Review
Frontiers in pharmacology
2020
144 اقتباسات
European journal of …
2020
91 اقتباسات
American journal of …
2020
47 اقتباسات
Naunyn-Schmiedeberg's archives of …
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37 اقتباسات
GeroScience
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31 اقتباسات
Scientific reports
2020
22 اقتباسات
Nutrients
2020
16 اقتباسات
Iranian journal of …
2020
5 اقتباسات
Molecules (Basel, Switzerland)
2019
126 اقتباسات
International journal of …
2018
248 اقتباسات
Frontiers in immunology
2018
200 اقتباسات
Journal of ovarian …
2018
197 اقتباسات
Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy.
Review
Pharmacological research
2018
107 اقتباسات
MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol.
Review
Medicines (Basel, Switzerland)
2018
23 اقتباسات
Current medicinal chemistry
2018
13 اقتباسات
Pharmacological research
2017
63 اقتباسات
Frontiers in neurology
2017
48 اقتباسات
BioMed research international
2015
22 اقتباسات
Current pharmacology reports
2015
Nutrition research (New …
2013
73 اقتباسات
Current pharmaceutical design
2012
54 اقتباسات
Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals.
Review
Nutrition reviews
2011
97 اقتباسات
Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.
Review
Molecular nutrition & …
2008
56 اقتباسات
Current drug targets
2006
92 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 150-500 mg/day
- immunesupport:
- 250-500 mg/day trans-resveratrol
الحد الأعلى: No established UL; generally well-tolerated up to 1,500 mg/day
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
أفضل وقت للتناول: With meals
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Headache
- ⚠ Joint pain at very high doses (>2.5 g/day)
- ⚠ Kidney issues at extremely high doses (case reports)
التفاعلات المعروفة
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk)
- ● CYP1A2, CYP3A4 substrates (may inhibit metabolism)
- ● Estrogen-sensitive conditions (weak estrogenic activity)
الحد الأقصى المسموح به: No established UL; generally well-tolerated up to 1,500 mg/day
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Resveratrol help with Chronic Inflammation?
Based on 5 studies with 300 participants, there is limited but promising evidence that Resveratrol may support Chronic Inflammation management. Our evidence grade is C (Some Evidence).
How much Resveratrol should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Resveratrol?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Headache, Joint pain at very high doses (>2.5 g/day), Kidney issues at extremely high doses (case reports). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Resveratrol and Chronic Inflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Chronic Inflammation
References
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