Resveratrol for Chronic Inflammation
CPreclinical models demonstrate immunomodulatory and anti-inflammatory effects through SIRT1 and NF-kB modulation. Human trials show reduction in CRP and other inflammatory markers, though low oral bioavailability remains a key limitation.
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C
The Bottom Line
Preclinical models demonstrate immunomodulatory and anti-inflammatory effects through SIRT1 and NF-kB modulation. Human trials show reduction in CRP and other inflammatory markers, though low oral bioavailability remains a key limitation.
Key Study Findings
Review
Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol.
Dose: None
vs: None
Outcome: None
Effect: None
None
Population: None
Review
Modulating Ferroptosis in Aging: The Therapeutic Potential of Natural Products.
Dose: None
vs: None
Outcome: None
Effect: None
None
Population: None
Review
Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer's Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty …
Dose: None
vs: None
Outcome: None
Effect: None
None
Population: None
Review
Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovascular Drugs and Future Directions.
Dose: None
vs: None
Outcome: None
Effect: None
None
Population: None
In Vitro
Resveratrol derivative SH-707 inhibits NLRP3 inflammasome activation via a sirtuin 1-dependent pathway.
Dose: None
vs: LPS-induced septic mouse model vs control
Outcome: IL-1β secretion and NLRP3 inflammasome activation
Effect: None
None
Population: Macrophages and LPS-induced septic mouse model
Other
Gut microbiota-metabolite crosstalk mediates icariin's protection against obesity-induced spermatogenic dysfunction through NF-κB/AMH axis in Sertoli …
Dose: None
vs: HFD mouse model vs control
Outcome: Testicular morphology and spermatogenesis markers
Effect: None
None
Population: HFD-induced obese mouse model (spermatogenesis)
Key Statistics
5
Studies
300
Participants
↑
Positive
C
Grade
Referenced Papers
ESC heart failure
2025
58 citations
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Review
Nutrients
2025
32 citations
Nutrients
2025
32 citations
International journal of …
2025
32 citations
Pathology, research and …
2025
26 citations
Immunity & ageing …
2025
25 citations
Molecular neurobiology
2025
23 citations
Nutrients
2025
10 citations
Journal of aging …
2025
10 citations
Biomedicines
2025
8 citations
International journal of …
2025
5 citations
Current issues in …
2025
5 citations
International immunopharmacology
2025
3 citations
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Systematic Review
Frontiers in immunology
2025
1 citations
Phytomedicine : international …
2025
1 citations
International journal of …
2024
27 citations
Journal of hazardous …
2024
20 citations
Journal of ovarian …
2024
13 citations
Antitumor Effects of Resveratrol Opposing Mechanisms of Helicobacter pylori in Gastric Cancer.
Review
Nutrients
2024
12 citations
Biology of reproduction
2024
9 citations
Oncology research
2024
8 citations
International journal of …
2024
3 citations
Zhonghua wei zhong …
2024
1 citations
Voprosy pitaniia
2023
19 citations
Cancer investigation
2023
6 citations
Complementary therapies in …
2022
115 citations
Nutrition research (New …
2022
75 citations
Nutrients
2022
26 citations
The Journal of …
2021
117 citations
International journal of …
2021
20 citations
Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease.
Review
Frontiers in pharmacology
2020
144 citations
European journal of …
2020
91 citations
American journal of …
2020
47 citations
Naunyn-Schmiedeberg's archives of …
2020
37 citations
GeroScience
2020
31 citations
Scientific reports
2020
22 citations
Nutrients
2020
16 citations
Iranian journal of …
2020
5 citations
Molecules (Basel, Switzerland)
2019
126 citations
International journal of …
2018
248 citations
Frontiers in immunology
2018
200 citations
Journal of ovarian …
2018
197 citations
Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy.
Review
Pharmacological research
2018
107 citations
MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol.
Review
Medicines (Basel, Switzerland)
2018
23 citations
Current medicinal chemistry
2018
13 citations
Pharmacological research
2017
63 citations
Frontiers in neurology
2017
48 citations
BioMed research international
2015
22 citations
Current pharmacology reports
2015
Nutrition research (New …
2013
73 citations
Current pharmaceutical design
2012
54 citations
Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals.
Review
Nutrition reviews
2011
97 citations
Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.
Review
Molecular nutrition & …
2008
56 citations
Current drug targets
2006
92 citations
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Commonly Used Dosages
- general:
- 150-500 mg/day
- immunesupport:
- 250-500 mg/day trans-resveratrol
Upper limit: No established UL; generally well-tolerated up to 1,500 mg/day
Dosages Studied in Research
| Dosage | Duration | Effect | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
Best taken: With meals
Safety & Side Effects
Reported Side Effects
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Headache
- ⚠ Joint pain at very high doses (>2.5 g/day)
- ⚠ Kidney issues at extremely high doses (case reports)
Known Interactions
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk)
- ● CYP1A2, CYP3A4 substrates (may inhibit metabolism)
- ● Estrogen-sensitive conditions (weak estrogenic activity)
Tolerable upper intake: No established UL; generally well-tolerated up to 1,500 mg/day
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
Does Resveratrol help with Chronic Inflammation?
Based on 5 studies with 300 participants, there is limited but promising evidence that Resveratrol may support Chronic Inflammation management. Our evidence grade is C (Some Evidence).
How much Resveratrol should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Resveratrol?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Headache, Joint pain at very high doses (>2.5 g/day), Kidney issues at extremely high doses (case reports). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Resveratrol and Chronic Inflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
Related Evidence
Other ingredients for Chronic Inflammation
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.