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ImmuneCited

Chaga Mushroom for Chronic Inflammation

D

Preclinical models show chaga triterpenes may reduce secretion of pro-inflammatory cytokines in macrophages. Beta-glucan polysaccharides demonstrate immunomodulatory activity in vitro. Robust human clinical trials are still needed to confirm benefits.

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The Bottom Line

            
            
Preclinical models show chaga triterpenes may reduce secretion of pro-inflammatory cytokines in macrophages. Beta-glucan polysaccharides demonstrate immunomodulatory activity in vitro. Robust human clinical trials are still needed to confirm benefits.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                2 weeks
                
                
                Double-blind
                
            

            
                Beet supplementation mitigates post-exercise inflammation.
            
            

                
                Dose: 212 mg
                
                
                vs: Placebo
                
                
                Outcome: Inflammatory markers
                
                
                Effect: None
                
                
                p < 0.001
                
            

            
            
Population: None

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
3

        
Studies

    

    

        
50

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        D

        
Grade

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Beet supplementation mitigates post-exercise inflammation.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Frontiers in nutrition
                        2024
                        
                        8 citations
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
500-1,500 mg extract/day

                    

                    
                    

                        
traditional:

                        
1-2 cups tea/day

                    

                    
                

                
                

                    Upper limit: No established UL; caution with blood thinners and kidney disease
                

                
            

            

            
            

                
Dosages Studied in Research

                

                    

                        
                            

                                Dosage
                                Duration
                                Effect
                                N
                            

                        
                        
                            
                            

                                212 mg
                                2 weeks
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Best taken: With or without food
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
  • 
                            ⚠
                            Oxalate content may contribute to kidney stones
                        
    • 
                        
                        
  • 
                            ⚠
                            Hypoglycemia risk
                        
    • 
                        
                        
  • 
                            ⚠
                            Potential anticoagulant effects
                        
    • 
                        
                        
  • 
                            ⚠
                            Limited safety data for long-term use
                        
    • 
                        
                    

                

                

                
                

                    
Known Interactions

                    
    
                        
                        
  • 
                            ●
                            Anticoagulants and antiplatelet drugs (may increase bleeding risk)
                        
    • 
                        
                        
  • 
                            ●
                            Diabetes medications (may lower blood sugar)
                        
    • 
                        
                        
  • 
                            ●
                            Immunosuppressant medications (may counteract immunosuppression)
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerable upper intake: No established UL; caution with blood thinners and kidney disease
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Chaga Mushroom help with Chronic Inflammation?
            
        
        

            Based on 3 studies with 50 participants, there is preliminary evidence that needs more research that Chaga Mushroom may support Chronic Inflammation management. Our evidence grade is D (Very Early Research).
        

    

    
    

        
            How much Chaga Mushroom should I take for Chronic Inflammation?
            
        
        

            Studies have used various dosages. A commonly studied range is 500-1,500 mg extract/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Chaga Mushroom?
            
        
        

            Reported side effects may include Oxalate content may contribute to kidney stones, Hypoglycemia risk, Potential anticoagulant effects, Limited safety data for long-term use. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Chaga Mushroom and Chronic Inflammation?
            
        
        

            We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 50 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
            

        

        

    


    
    












    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.