Resveratrol के लिए Chronic Inflammation

Preclinical models demonstrate immunomodulatory and anti-inflammatory effects through SIRT1 and NF-kB modulation. Human trials show reduction in CRP and other inflammatory markers, though low oral bioavailability remains a key limitation.

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निष्कर्ष

Key Study Findings

Review

Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol.

Dose: None बनाम: None Outcome: None प्रभाव: None None

जनसंख्या: None

Review

Modulating Ferroptosis in Aging: The Therapeutic Potential of Natural Products.

Dose: None बनाम: None Outcome: None प्रभाव: None None

जनसंख्या: None

Review

Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer's Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty …

Dose: None बनाम: None Outcome: None प्रभाव: None None

जनसंख्या: None

Review

Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovascular Drugs and Future Directions.

Dose: None बनाम: None Outcome: None प्रभाव: None None

जनसंख्या: None

In Vitro

Resveratrol derivative SH-707 inhibits NLRP3 inflammasome activation via a sirtuin 1-dependent pathway.

Dose: None बनाम: LPS-induced septic mouse model vs control Outcome: IL-1β secretion and NLRP3 inflammasome activation प्रभाव: None None

जनसंख्या: Macrophages and LPS-induced septic mouse model

Other

Gut microbiota-metabolite crosstalk mediates icariin's protection against obesity-induced spermatogenic dysfunction through NF-κB/AMH axis in Sertoli …

Dose: None बनाम: HFD mouse model vs control Outcome: Testicular morphology and spermatogenesis markers प्रभाव: None None

जनसंख्या: HFD-induced obese mouse model (spermatogenesis)

Key Statistics

अध्ययन

300

प्रतिभागी

↑

Positive

ग्रेड

Referenced Papers

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues. Review

ESC heart failure 2025 58 उद्धरण

Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus. Review

Nutrients 2025 32 उद्धरण

Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk. Review

Nutrients 2025 32 उद्धरण

Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications. Review

International journal of … 2025 32 उद्धरण

Pathological interplay of NF-κB and M1 macrophages in chronic inflammatory lung diseases. Review

Pathology, research and … 2025 26 उद्धरण

Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol. Review

Immunity & ageing … 2025 25 उद्धरण

The Potential of Mitochondrial Therapeutics in the Treatment of Oxidative Stress and Inflammation in Aging. Review

Molecular neurobiology 2025 23 उद्धरण

Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer's Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty Acids. Review

Nutrients 2025 10 उद्धरण

Modulating Ferroptosis in Aging: The Therapeutic Potential of Natural Products. Review

Journal of aging … 2025 10 उद्धरण

Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovascular Drugs and Future Directions. Review

Biomedicines 2025 8 उद्धरण

Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of Exercise. Review

International journal of … 2025 5 उद्धरण

Antioxidant Naturally Occurring Pleiotropically Acting Bioactive Compounds, as Polymeric Nanotherapeutics Against Autoimmune Diseases Progression. Review

Current issues in … 2025 5 उद्धरण

Resveratrol derivative SH-707 inhibits NLRP3 inflammasome activation via a sirtuin 1-dependent pathway. Other

International immunopharmacology 2025 3 उद्धरण

Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases. Systematic Review

Frontiers in immunology 2025 1 उद्धरण

Gut microbiota-metabolite crosstalk mediates icariin's protection against obesity-induced spermatogenic dysfunction through NF-κB/AMH axis in Sertoli cells. Other

Phytomedicine : international … 2025 1 उद्धरण

Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)? Review

International journal of … 2024 27 उद्धरण

Particulate matter-induced metabolic recoding of epigenetics in macrophages drives pathogenesis of chronic obstructive pulmonary disease. Other

Journal of hazardous … 2024 20 उद्धरण

Role of polyphenols in remodeling the host gut microbiota in polycystic ovary syndrome. Review

Journal of ovarian … 2024 13 उद्धरण

Antitumor Effects of Resveratrol Opposing Mechanisms of Helicobacter pylori in Gastric Cancer. Review

Nutrients 2024 12 उद्धरण

Resveratrol improves follicular development in PCOS rats by inhibiting the inflammatory response and pyroptosis of granulosa cells. Other

Biology of reproduction 2024 9 उद्धरण

Immunomodulatory and chemopreventive effects of resveratrol on the digestive system cancers. Review

Oncology research 2024 8 उद्धरण

Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies. Other

International journal of … 2024 3 उद्धरण

[Protective effect and mechanism of resveratrol on vascular endothelial cells]. Review

Zhonghua wei zhong … 2024 1 उद्धरण

[Polyphenols as promising bioactive compounds]. Other

Voprosy pitaniia 2023 19 उद्धरण

The Journey of Resveratrol from Vineyards to Clinics. Other

Cancer investigation 2023 6 उद्धरण

Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: … RCT

Complementary therapies in … 2022 115 उद्धरण

Bioactive compounds modulating Toll-like 4 receptor (TLR4)-mediated inflammation: pathways involved and future perspectives. Review

Nutrition research (New … 2022 75 उद्धरण

Protective Effects of Dietary Resveratrol against Chronic Low-Grade Inflammation Mediated through the Gut Microbiota in High-Fat Diet Mice. Other

Nutrients 2022 26 उद्धरण

Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways. Review

The Journal of … 2021 117 उद्धरण

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction. Review

International journal of … 2021 20 उद्धरण

Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease. Review

Frontiers in pharmacology 2020 144 उद्धरण

Targeting Keap1/Nrf2/ARE signaling pathway in multiple sclerosis. Review

European journal of … 2020 91 उद्धरण

Controlling chronic low-grade inflammation to improve follicle development and survival. Review

American journal of … 2020 47 उद्धरण

Resveratrol prevents diabetic nephropathy by reducing chronic inflammation and improving the blood glucose memory effect in non-obese diabetic mice. Other

Naunyn-Schmiedeberg's archives of … 2020 37 उद्धरण

Nanodelivery of phytobioactive compounds for treating aging-associated disorders. Review

GeroScience 2020 31 उद्धरण

Resveratrol attenuates TLR-4 mediated inflammation and elicits therapeutic potential in models of sepsis. Other

Scientific reports 2020 22 उद्धरण

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. Other

Nutrients 2020 16 उद्धरण

Looking for immortality: Review of phytotherapy for stem cell senescence. Review

Iranian journal of … 2020 5 उद्धरण

Therapeutic Approaches of Resveratrol on Endometriosis via Anti-Inflammatory and Anti-Angiogenic Pathways. Review

Molecules (Basel, Switzerland) 2019 126 उद्धरण

Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights. Review

International journal of … 2018 248 उद्धरण

Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases. Review

Frontiers in immunology 2018 200 उद्धरण

Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study. Other

Journal of ovarian … 2018 197 उद्धरण

Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy. Review

Pharmacological research 2018 107 उद्धरण

MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol. Review

Medicines (Basel, Switzerland) 2018 23 उद्धरण

Dopaminergic Neuroprotection with Atremorine in Parkinson´s Disease. Review

Current medicinal chemistry 2018 13 उद्धरण

Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury. Other

Pharmacological research 2017 63 उद्धरण

Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are We There Yet? Review

Frontiers in neurology 2017 48 उद्धरण

ω-3 PUFAs and Resveratrol Differently Modulate Acute and Chronic Inflammatory Processes. Other

BioMed research international 2015 22 उद्धरण

Resveratrol and Malignancies. Other

Current pharmacology reports 2015

Resveratrol prevents suppression of regulatory T-cell production, oxidative stress, and inflammation of mice prone or resistant to high-fat diet-induced obesity. Other

Nutrition research (New … 2013 73 उद्धरण

Chemoprevention with phytonutrients and microalgae products in chronic inflammation and colon cancer. Review

Current pharmaceutical design 2012 54 उद्धरण

Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals. Review

Nutrition reviews 2011 97 उद्धरण

Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin. Review

Molecular nutrition & … 2008 56 उद्धरण

Antioxidant therapeutic targets in COPD. Review

Current drug targets 2006 92 उद्धरण

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

सामान्य रूप से उपयोग की जाने वाली खुराकें

general:: 150-500 mg/day
immunesupport:: 250-500 mg/day trans-resveratrol

अधिकतम सीमा: No established UL; generally well-tolerated up to 1,500 mg/day

अनुसंधान में अध्ययन की गई खुराकें

खुराक	अवधि	प्रभाव	N
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
None	--	Positive	--

सेवन का सर्वोत्तम समय: With meals

Safety & Side Effects

रिपोर्ट किए गए दुष्प्रभाव

⚠ Gastrointestinal discomfort (nausea, diarrhea)
⚠ Headache
⚠ Joint pain at very high doses (>2.5 g/day)
⚠ Kidney issues at extremely high doses (case reports)

ज्ञात अंतःक्रियाएँ

● Anticoagulants and antiplatelet drugs (may increase bleeding risk)
● CYP1A2, CYP3A4 substrates (may inhibit metabolism)
● Estrogen-sensitive conditions (weak estrogenic activity)

सहनीय अधिकतम सेवन: No established UL; generally well-tolerated up to 1,500 mg/day

कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।

Frequently Asked Questions

Does Resveratrol help with Chronic Inflammation?

Based on 5 studies with 300 participants, there is limited but promising evidence that Resveratrol may support Chronic Inflammation management. Our evidence grade is C (Some Evidence).

How much Resveratrol should I take for Chronic Inflammation?

Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Resveratrol?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Headache, Joint pain at very high doses (>2.5 g/day), Kidney issues at extremely high doses (case reports). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Resveratrol and Chronic Inflammation?

We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Related Evidence

इसके लिए अन्य सामग्री Chronic Inflammation

Omega-3 Fatty Acids (EPA/DHA) A Curcumin A Chaga Mushroom D Conjugated Linoleic Acid D

संक्षिप्त निष्कर्ष

Evidence Strength52%

Moderate confidence

अध्ययन विश्लेषण

RCT (1)Meta (0)Other (4)

विकल्पों की तुलना करें

देखें कि इस स्वास्थ्य स्थिति के लिए अन्य सामग्री की तुलना कैसे है।

इसके लिए सभी सामग्री देखें Chronic Inflammation

अधिक जानें

FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।