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ImmuneCited

Resveratrol для Chronic Inflammation

C

Preclinical models demonstrate immunomodulatory and anti-inflammatory effects through SIRT1 and NF-kB modulation. Human trials show reduction in CRP and other inflammatory markers, though low oral bioavailability remains a key limitation.

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C

Итог

Preclinical models demonstrate immunomodulatory and anti-inflammatory effects through SIRT1 and NF-kB modulation. Human trials show reduction in CRP and other inflammatory markers, though low oral bioavailability remains a key limitation.

Key Study Findings

Review
Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol.
Dose: None или: None Outcome: None Эффект: None None

Популяция: None

Review
Modulating Ferroptosis in Aging: The Therapeutic Potential of Natural Products.
Dose: None или: None Outcome: None Эффект: None None

Популяция: None

Review
Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer's Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty …
Dose: None или: None Outcome: None Эффект: None None

Популяция: None

Review
Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovascular Drugs and Future Directions.
Dose: None или: None Outcome: None Эффект: None None

Популяция: None

In Vitro
Resveratrol derivative SH-707 inhibits NLRP3 inflammasome activation via a sirtuin 1-dependent pathway.
Dose: None или: LPS-induced septic mouse model vs control Outcome: IL-1β secretion and NLRP3 inflammasome activation Эффект: None None

Популяция: Macrophages and LPS-induced septic mouse model

Other
Gut microbiota-metabolite crosstalk mediates icariin's protection against obesity-induced spermatogenic dysfunction through NF-κB/AMH axis in Sertoli …
Dose: None или: HFD mouse model vs control Outcome: Testicular morphology and spermatogenesis markers Эффект: None None

Популяция: HFD-induced obese mouse model (spermatogenesis)

Key Statistics

5

Исследования

300

Участники

Positive

C

Оценка

Referenced Papers

ESC heart failure 2025 58 цитирований
Pathology, research and … 2025 26 цитирований
Journal of aging … 2025 10 цитирований
Frontiers in immunology 2025 1 цитирований
International journal of … 2024 27 цитирований
Journal of ovarian … 2024 13 цитирований
International journal of … 2024 3 цитирований
Zhonghua wei zhong … 2024 1 цитирований
Voprosy pitaniia 2023 19 цитирований
Cancer investigation 2023 6 цитирований
Frontiers in pharmacology 2020 144 цитирований
European journal of … 2020 91 цитирований
American journal of … 2020 47 цитирований
Iranian journal of … 2020 5 цитирований
International journal of … 2018 248 цитирований
Frontiers in immunology 2018 200 цитирований
Pharmacological research 2018 107 цитирований
Medicines (Basel, Switzerland) 2018 23 цитирований
Current medicinal chemistry 2018 13 цитирований
BioMed research international 2015 22 цитирований
Current pharmacology reports 2015
Current drug targets 2006 92 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:
150-500 mg/day
immunesupport:
250-500 mg/day trans-resveratrol

Верхний предел: No established UL; generally well-tolerated up to 1,500 mg/day

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Mixed --
None -- Mixed --
None -- Mixed --
None -- Mixed --
None -- Positive --
None -- Positive --
None -- Mixed --
None -- Positive --

Лучшее время приёма: With meals

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Gastrointestinal discomfort (nausea, diarrhea)
  • Headache
  • Joint pain at very high doses (>2.5 g/day)
  • Kidney issues at extremely high doses (case reports)

Известные взаимодействия

  • Anticoagulants and antiplatelet drugs (may increase bleeding risk)
  • CYP1A2, CYP3A4 substrates (may inhibit metabolism)
  • Estrogen-sensitive conditions (weak estrogenic activity)

Допустимый верхний уровень потребления: No established UL; generally well-tolerated up to 1,500 mg/day

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Resveratrol help with Chronic Inflammation?
Based on 5 studies with 300 participants, there is limited but promising evidence that Resveratrol may support Chronic Inflammation management. Our evidence grade is C (Some Evidence).
How much Resveratrol should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Resveratrol?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Headache, Joint pain at very high doses (>2.5 g/day), Kidney issues at extremely high doses (case reports). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Resveratrol and Chronic Inflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Related Evidence

Другие ингредиенты для Chronic Inflammation

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