Resveratrol untuk Chronic Inflammation
C Bukti Bukti terbatas dari studi kecil, namun beberapa sinyal positif ada.Preclinical models demonstrate immunomodulatory and anti-inflammatory effects through SIRT1 and NF-kB modulation. Human trials show reduction in CRP and other inflammatory markers, though low oral bioavailability remains a key limitation.
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C
Kesimpulan
Preclinical models demonstrate immunomodulatory and anti-inflammatory effects through SIRT1 and NF-kB modulation. Human trials show reduction in CRP and other inflammatory markers, though low oral bioavailability remains a key limitation.
Key Study Findings
Review
Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol.
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: None
Review
Modulating Ferroptosis in Aging: The Therapeutic Potential of Natural Products.
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: None
Review
Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer's Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty …
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: None
Review
Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovascular Drugs and Future Directions.
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: None
In Vitro
Resveratrol derivative SH-707 inhibits NLRP3 inflammasome activation via a sirtuin 1-dependent pathway.
Dose: None
vs: LPS-induced septic mouse model vs control
Outcome: IL-1β secretion and NLRP3 inflammasome activation
Efek: None
None
Populasi: Macrophages and LPS-induced septic mouse model
Other
Gut microbiota-metabolite crosstalk mediates icariin's protection against obesity-induced spermatogenic dysfunction through NF-κB/AMH axis in Sertoli …
Dose: None
vs: HFD mouse model vs control
Outcome: Testicular morphology and spermatogenesis markers
Efek: None
None
Populasi: HFD-induced obese mouse model (spermatogenesis)
Key Statistics
5
Studi
300
Peserta
↑
Positive
C
Peringkat
Referenced Papers
ESC heart failure
2025
58 sitasi
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Review
Nutrients
2025
32 sitasi
Nutrients
2025
32 sitasi
International journal of …
2025
32 sitasi
Pathology, research and …
2025
26 sitasi
Immunity & ageing …
2025
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Molecular neurobiology
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Nutrients
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Journal of aging …
2025
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Biomedicines
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International journal of …
2025
5 sitasi
Current issues in …
2025
5 sitasi
International immunopharmacology
2025
3 sitasi
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Systematic Review
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2025
1 sitasi
Phytomedicine : international …
2025
1 sitasi
International journal of …
2024
27 sitasi
Journal of hazardous …
2024
20 sitasi
Journal of ovarian …
2024
13 sitasi
Antitumor Effects of Resveratrol Opposing Mechanisms of Helicobacter pylori in Gastric Cancer.
Review
Nutrients
2024
12 sitasi
Biology of reproduction
2024
9 sitasi
Oncology research
2024
8 sitasi
International journal of …
2024
3 sitasi
Zhonghua wei zhong …
2024
1 sitasi
Voprosy pitaniia
2023
19 sitasi
Cancer investigation
2023
6 sitasi
Complementary therapies in …
2022
115 sitasi
Nutrition research (New …
2022
75 sitasi
Nutrients
2022
26 sitasi
The Journal of …
2021
117 sitasi
International journal of …
2021
20 sitasi
Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease.
Review
Frontiers in pharmacology
2020
144 sitasi
European journal of …
2020
91 sitasi
American journal of …
2020
47 sitasi
Naunyn-Schmiedeberg's archives of …
2020
37 sitasi
GeroScience
2020
31 sitasi
Scientific reports
2020
22 sitasi
Nutrients
2020
16 sitasi
Iranian journal of …
2020
5 sitasi
Molecules (Basel, Switzerland)
2019
126 sitasi
International journal of …
2018
248 sitasi
Frontiers in immunology
2018
200 sitasi
Journal of ovarian …
2018
197 sitasi
Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy.
Review
Pharmacological research
2018
107 sitasi
MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol.
Review
Medicines (Basel, Switzerland)
2018
23 sitasi
Current medicinal chemistry
2018
13 sitasi
Pharmacological research
2017
63 sitasi
Frontiers in neurology
2017
48 sitasi
BioMed research international
2015
22 sitasi
Current pharmacology reports
2015
Nutrition research (New …
2013
73 sitasi
Current pharmaceutical design
2012
54 sitasi
Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals.
Review
Nutrition reviews
2011
97 sitasi
Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.
Review
Molecular nutrition & …
2008
56 sitasi
Current drug targets
2006
92 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 150-500 mg/day
- immunesupport:
- 250-500 mg/day trans-resveratrol
Batas atas: No established UL; generally well-tolerated up to 1,500 mg/day
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
Waktu terbaik diminum: With meals
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Headache
- ⚠ Joint pain at very high doses (>2.5 g/day)
- ⚠ Kidney issues at extremely high doses (case reports)
Interaksi yang Diketahui
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk)
- ● CYP1A2, CYP3A4 substrates (may inhibit metabolism)
- ● Estrogen-sensitive conditions (weak estrogenic activity)
Asupan atas yang dapat ditoleransi: No established UL; generally well-tolerated up to 1,500 mg/day
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Resveratrol help with Chronic Inflammation?
Based on 5 studies with 300 participants, there is limited but promising evidence that Resveratrol may support Chronic Inflammation management. Our evidence grade is C (Some Evidence).
How much Resveratrol should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Resveratrol?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Headache, Joint pain at very high doses (>2.5 g/day), Kidney issues at extremely high doses (case reports). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Resveratrol and Chronic Inflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
Related Evidence
Bahan lain untuk Chronic Inflammation
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