Resveratrol 用于 慢性炎症
C 证据 来自小型研究的证据有限，但存在一些积极信号。Preclinical models demonstrate immunomodulatory and anti-inflammatory effects through SIRT1 and NF-kB modulation. Human trials show reduction in CRP and other inflammatory markers, though low oral bioavailability remains a key limitation.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'immunecited.com';
const params = 'ingredient\u003Dresveratrol\u0026condition\u003Dchronic\u002Dinflammation';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
C
结论
Preclinical models demonstrate immunomodulatory and anti-inflammatory effects through SIRT1 and NF-kB modulation. Human trials show reduction in CRP and other inflammatory markers, though low oral bioavailability remains a key limitation.
Key Study Findings
Review
Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Review
Modulating Ferroptosis in Aging: The Therapeutic Potential of Natural Products.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Review
Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer's Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Review
Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovascular Drugs and Future Directions.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
In Vitro
Resveratrol derivative SH-707 inhibits NLRP3 inflammasome activation via a sirtuin 1-dependent pathway.
Dose: None
vs: LPS-induced septic mouse model vs control
Outcome: IL-1β secretion and NLRP3 inflammasome activation
效果: None
None
研究人群: Macrophages and LPS-induced septic mouse model
Other
Gut microbiota-metabolite crosstalk mediates icariin's protection against obesity-induced spermatogenic dysfunction through NF-κB/AMH axis in Sertoli …
Dose: None
vs: HFD mouse model vs control
Outcome: Testicular morphology and spermatogenesis markers
效果: None
None
研究人群: HFD-induced obese mouse model (spermatogenesis)
Key Statistics
5
研究数量
300
受试者
↑
Positive
C
等级
Referenced Papers
ESC heart failure
2025
58 次引用
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Review
Nutrients
2025
32 次引用
Nutrients
2025
32 次引用
International journal of …
2025
32 次引用
Pathology, research and …
2025
26 次引用
Immunity & ageing …
2025
25 次引用
Molecular neurobiology
2025
23 次引用
Nutrients
2025
10 次引用
Journal of aging …
2025
10 次引用
Biomedicines
2025
8 次引用
International journal of …
2025
5 次引用
Current issues in …
2025
5 次引用
International immunopharmacology
2025
3 次引用
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Systematic Review
Frontiers in immunology
2025
1 次引用
Phytomedicine : international …
2025
1 次引用
International journal of …
2024
27 次引用
Journal of hazardous …
2024
20 次引用
Journal of ovarian …
2024
13 次引用
Antitumor Effects of Resveratrol Opposing Mechanisms of Helicobacter pylori in Gastric Cancer.
Review
Nutrients
2024
12 次引用
Biology of reproduction
2024
9 次引用
Oncology research
2024
8 次引用
International journal of …
2024
3 次引用
Zhonghua wei zhong …
2024
1 次引用
Voprosy pitaniia
2023
19 次引用
Cancer investigation
2023
6 次引用
Complementary therapies in …
2022
115 次引用
Nutrition research (New …
2022
75 次引用
Nutrients
2022
26 次引用
The Journal of …
2021
117 次引用
International journal of …
2021
20 次引用
Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease.
Review
Frontiers in pharmacology
2020
144 次引用
European journal of …
2020
91 次引用
American journal of …
2020
47 次引用
Naunyn-Schmiedeberg's archives of …
2020
37 次引用
GeroScience
2020
31 次引用
Scientific reports
2020
22 次引用
Nutrients
2020
16 次引用
Iranian journal of …
2020
5 次引用
Molecules (Basel, Switzerland)
2019
126 次引用
International journal of …
2018
248 次引用
Frontiers in immunology
2018
200 次引用
Journal of ovarian …
2018
197 次引用
Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy.
Review
Pharmacological research
2018
107 次引用
MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol.
Review
Medicines (Basel, Switzerland)
2018
23 次引用
Current medicinal chemistry
2018
13 次引用
Pharmacological research
2017
63 次引用
Frontiers in neurology
2017
48 次引用
BioMed research international
2015
22 次引用
Current pharmacology reports
2015
Nutrition research (New …
2013
73 次引用
Current pharmaceutical design
2012
54 次引用
Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals.
Review
Nutrition reviews
2011
97 次引用
Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.
Review
Molecular nutrition & …
2008
56 次引用
Current drug targets
2006
92 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 150-500 mg/day
- immunesupport:
- 250-500 mg/day trans-resveratrol
上限： No established UL; generally well-tolerated up to 1,500 mg/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
最佳服用时间： With meals
Safety & Side Effects
已报告的副作用
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Headache
- ⚠ Joint pain at very high doses (>2.5 g/day)
- ⚠ Kidney issues at extremely high doses (case reports)
已知相互作用
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk)
- ● CYP1A2, CYP3A4 substrates (may inhibit metabolism)
- ● Estrogen-sensitive conditions (weak estrogenic activity)
可耐受最高摄入量： No established UL; generally well-tolerated up to 1,500 mg/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Resveratrol help with 慢性炎症?
Based on 5 studies with 300 participants, there is limited but promising evidence that Resveratrol may support 慢性炎症 management. Our evidence grade is C (Some Evidence).
How much Resveratrol should I take for 慢性炎症?
Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Resveratrol?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Headache, Joint pain at very high doses (>2.5 g/day), Kidney issues at extremely high doses (case reports). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Resveratrol and 慢性炎症?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
Related Evidence
References
- [1] Zhuyubing Fang et al.. ESC Heart Fail. 2025. Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues. doi:10.1002/ehf2.14947 PubMed
- [2] Monika Martiniakova et al.. Nutrients. 2025. Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus. doi:10.3390/nu17020275 PubMed
- [3] Hygerta Berisha et al.. Nutrients. 2025. Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk. doi:10.3390/nu17050776 PubMed
- [4] Kazuhiko Nakadate et al.. Int J Mol Sci. 2025. Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications. doi:10.3390/ijms26115206 PubMed
- [5] Fadiyah Jadid Alanazi et al.. Pathol Res Pract. 2025. Pathological interplay of NF-κB and M1 macrophages in chronic inflammatory lung diseases. doi:10.1016/j.prp.2025.155903 PubMed
- [6] Mohamed Ahmed. Immun Ageing. 2025. Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol. doi:10.1186/s12979-025-00522-y PubMed
- [7] Jitendra Kumar Sinha et al.. Mol Neurobiol. 2025. The Potential of Mitochondrial Therapeutics in the Treatment of Oxidative Stress and Inflammation in Aging. doi:10.1007/s12035-024-04474-0 PubMed
- [8] Mahsa Yavari et al.. Nutrients. 2025. Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer's Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty Acids. doi:10.3390/nu17071203 PubMed
- [9] Sherif Hamidu et al.. J Aging Res. 2025. Modulating Ferroptosis in Aging: The Therapeutic Potential of Natural Products. doi:10.1155/jare/8832992 PubMed
- [10] Toshiki Otoda et al.. Biomedicines. 2025. Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovascular Drugs and Future Directions. doi:10.3390/biomedicines13051053 PubMed
- [11] Angela Falvino et al.. Int J Mol Sci. 2025. Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of Exercise. doi:10.3390/ijms26157573 PubMed
- [12] Panagiotis Theodosis-Nobelos et al.. Curr Issues Mol Biol. 2025. Antioxidant Naturally Occurring Pleiotropically Acting Bioactive Compounds, as Polymeric Nanotherapeutics Against Autoimmune Diseases Progression. doi:10.3390/cimb47060411 PubMed
- [13] Kyung Tae Kim et al.. Int Immunopharmacol. 2025. Resveratrol derivative SH-707 inhibits NLRP3 inflammasome activation via a sirtuin 1-dependent pathway. doi:10.1016/j.intimp.2025.115049 PubMed
- [14] Yuhan Wang et al.. Front Immunol. 2025. Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases. doi:10.3389/fimmu.2025.1629288 PubMed
- [15] Qiumei Huang et al.. Phytomedicine. 2025. Gut microbiota-metabolite crosstalk mediates icariin's protection against obesity-induced spermatogenic dysfunction through NF-κB/AMH axis in Sertoli cells. doi:10.1016/j.phymed.2025.157490 PubMed
- [16] Kamila Kasprzak-Drozd et al.. Int J Mol Sci. 2024. Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)? doi:10.3390/ijms25073746 PubMed
- [17] Myungkyung Noh et al.. J Hazard Mater. 2024. Particulate matter-induced metabolic recoding of epigenetics in macrophages drives pathogenesis of chronic obstructive pulmonary disease. doi:10.1016/j.jhazmat.2023.132932 PubMed
- [18] Ping Zhou et al.. J Ovarian Res. 2024. Role of polyphenols in remodeling the host gut microbiota in polycystic ovary syndrome. doi:10.1186/s13048-024-01354-y PubMed
- [19] Daniela Trautmann et al.. Nutrients. 2024. Antitumor Effects of Resveratrol Opposing Mechanisms of Helicobacter pylori in Gastric Cancer. doi:10.3390/nu16132141 PubMed
- [20] Huimei Wei et al.. Biol Reprod. 2024. Resveratrol improves follicular development in PCOS rats by inhibiting the inflammatory response and pyroptosis of granulosa cells. doi:10.1093/biolre/ioae160 PubMed
- [21] Meir Djaldetti. Oncol Res. 2024. Immunomodulatory and chemopreventive effects of resveratrol on the digestive system cancers. doi:10.32604/or.2024.049745 PubMed
- [22] Xuefei Zhang et al.. Int J Nanomedicine. 2024. Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies. doi:10.2147/IJN.S477820 PubMed
- [23] Yang Yang et al.. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2024. [Protective effect and mechanism of resveratrol on vascular endothelial cells]. doi:10.3760/cma.j.cn121430-20240103-00011 PubMed
- [24] T N Bobrysheva et al.. Vopr Pitan. 2023. [Polyphenols as promising bioactive compounds]. doi:10.33029/0042-8833-2023-92-1-92-107 PubMed
- [25] Ramya Venkat et al.. Cancer Invest. 2023. The Journey of Resveratrol from Vineyards to Clinics. doi:10.1080/07357907.2022.2115057 PubMed
- [26] Wajiha Mahjabeen et al.. Complement Ther Med. 2022. Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: … doi:10.1016/j.ctim.2022.102819 PubMed
- [27] Karen S Coutinho-Wolino et al.. Nutr Res. 2022. Bioactive compounds modulating Toll-like 4 receptor (TLR4)-mediated inflammation: pathways involved and future perspectives. doi:10.1016/j.nutres.2022.09.001 PubMed
- [28] Pan Wang et al.. Nutrients. 2022. Protective Effects of Dietary Resveratrol against Chronic Low-Grade Inflammation Mediated through the Gut Microbiota in High-Fat Diet Mice. doi:10.3390/nu14101994 PubMed
- [29] Ibrahim Jantan et al.. J Nutr Biochem. 2021. Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways. doi:10.1016/j.jnutbio.2021.108634 PubMed
- [30] Pamela Senesi et al.. Int J Mol Sci. 2021. Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction. doi:10.3390/ijms22157772 PubMed
- [31] Md Habibur Rahman et al.. Front Pharmacol. 2020. Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease. doi:10.3389/fphar.2020.619024 PubMed
- [32] Danica Michaličková et al.. Eur J Pharmacol. 2020. Targeting Keap1/Nrf2/ARE signaling pathway in multiple sclerosis. doi:10.1016/j.ejphar.2020.172973 PubMed
- [33] Ziwei Yang et al.. Am J Reprod Immunol. 2020. Controlling chronic low-grade inflammation to improve follicle development and survival. doi:10.1111/aji.13265 PubMed
- [34] Yuxin Xian et al.. Naunyn Schmiedebergs Arch Pharmacol. 2020. Resveratrol prevents diabetic nephropathy by reducing chronic inflammation and improving the blood glucose memory effect in non-obese diabetic mice. doi:10.1007/s00210-019-01777-1 PubMed
- [35] Oleh Lushchak et al.. Geroscience. 2020. Nanodelivery of phytobioactive compounds for treating aging-associated disorders. doi:10.1007/s11357-019-00116-9 PubMed
- [36] Binbin Wang et al.. Sci Rep. 2020. Resveratrol attenuates TLR-4 mediated inflammation and elicits therapeutic potential in models of sepsis. doi:10.1038/s41598-020-74578-9 PubMed
- [37] Raúl Francisco Pastor et al.. Nutrients. 2020. Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. doi:10.3390/nu12103149 PubMed
- [38] Hourieh Tousian et al.. Iran J Basic Med Sci. 2020. Looking for immortality: Review of phytotherapy for stem cell senescence. doi:10.22038/IJBMS.2019.40223.9522 PubMed
- [39] Ana-Maria Dull et al.. Molecules. 2019. Therapeutic Approaches of Resveratrol on Endometriosis via Anti-Inflammatory and Anti-Angiogenic Pathways. doi:10.3390/molecules24040667 PubMed
- [40] Diego de Sá Coutinho et al.. Int J Mol Sci. 2018. Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights. doi:10.3390/ijms19061812 PubMed
- [41] Subash Chandra Gupta et al.. Front Immunol. 2018. Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases. doi:10.3389/fimmu.2018.02160 PubMed
- [42] Selenay Furat Rencber et al.. J Ovarian Res. 2018. Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study. doi:10.1186/s13048-018-0427-7 PubMed
- [43] Chitra Rajagopal et al.. Pharmacol Res. 2018. Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy. doi:10.1016/j.phrs.2017.12.034 PubMed
- [44] Jean-Jacques Michaille et al.. Medicines (Basel). 2018. MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol. doi:10.3390/medicines5030074 PubMed
- [45] Ivan Carrera et al.. Curr Med Chem. 2018. Dopaminergic Neuroprotection with Atremorine in Parkinson´s Disease. doi:10.2174/0929867325666180410100559 PubMed
- [46] Enrico Gugliandolo et al.. Pharmacol Res. 2017. Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury. doi:10.1016/j.phrs.2017.06.014 PubMed
- [47] Olagide W Castro et al.. Front Neurol. 2017. Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are We There Yet? doi:10.3389/fneur.2017.00603 PubMed
- [48] Joseph Schwager et al.. Biomed Res Int. 2015. ω-3 PUFAs and Resveratrol Differently Modulate Acute and Chronic Inflammatory Processes. doi:10.1155/2015/535189 PubMed
- [49] Rodica P Bunaciu et al.. Curr Pharmacol Rep. 2015. Resveratrol and Malignancies. doi:10.1007/s40495-015-0030-1 PubMed
- [50] Bin Wang et al.. Nutr Res. 2013. Resveratrol prevents suppression of regulatory T-cell production, oxidative stress, and inflammation of mice prone or resistant to high-fat diet-induced obesity. doi:10.1016/j.nutres.2013.07.016 PubMed
- [51] Elena Talero et al.. Curr Pharm Des. 2012. Chemoprevention with phytonutrients and microalgae products in chronic inflammation and colon cancer. doi:10.2174/138161212802083725 PubMed
- [52] Ling Zhao et al.. Nutr Rev. 2011. Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals. doi:10.1111/j.1753-4887.2011.00394.x PubMed
- [53] Saibal Biswas et al.. Mol Nutr Food Res. 2008. Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin. doi:10.1002/mnfr.200700259 PubMed
- [54] Irfan Rahman et al.. Curr Drug Targets. 2006. Antioxidant therapeutic targets in COPD. doi:10.2174/138945006777435254 PubMed
FDA 免责声明: 这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。