Omega-3 Fatty Acids (EPA/DHA) ： Chronic Inflammation
A エビデンス 複数の大規模臨床試験が一貫して有意な効果を示しています。The VITAL trial and multiple randomized controlled trials demonstrate omega-3 fatty acids may help reduce CRP and modulate inflammatory cytokines. DHA showed stronger anti-inflammatory effects than EPA, lowering 4 pro-inflammatory proteins versus 1 in a randomized study.
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A
結論
The VITAL trial and multiple randomized controlled trials demonstrate omega-3 fatty acids may help reduce CRP and modulate inflammatory cytokines. DHA showed stronger anti-inflammatory effects than EPA, lowering 4 pro-inflammatory proteins versus 1 in a randomized study.
Key Study Findings
Review
Specialized pro-resolving mediators and autoimmunity: Recent insights and future perspectives.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
Proresolving Lipid Mediators in the Respiratory System.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Other
The omega effect: Harnessing fish oil for health.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
Medical Nutrition Therapy in Dermatological Diseases: A Joint Consensus Statement of the Italian Association of …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Patients with acne, HS, or psoriasis
Systematic Review
Impact of Vegan and Vegetarian Diets on Neurological Health: A Critical Review.
Dose: None
vs: None
Outcome: Neurological health outcomes
効果: None
None
対象集団: None
Review
Immunomodulatory Effects of Omega-3 Fatty Acids: Mechanistic Insights and Health Implications.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: review of omega-3 fatty acids' immunomodulatory effects
Key Statistics
30
研究数
30000
参加者数
↑
Positive
A
グレード
Referenced Papers
Immunomodulatory Effects of Omega-3 Fatty Acids: Mechanistic Insights and Health Implications.
Review
Molecular nutrition & …
2025
44 件の引用
Nutrients
2025
22 件の引用
Annual review of …
2025
13 件の引用
Specialized pro-resolving mediators and autoimmunity: Recent insights and future perspectives.
Review
Autoimmunity reviews
2025
10 件の引用
Nutrients
2025
6 件の引用
Frontiers in immunology
2025
5 件の引用
Prostaglandins & other …
2025
3 件の引用
Lipids in health …
2025
3 件の引用
International journal of …
2025
3 件の引用
Nutrients
2025
2 件の引用
Atherosclerosis
2025
Current obesity reports
2025
The effects of ω-3 fatty acids on inflammatory and oxidative stress markers in patients with Type 2 diabetes mellitus: A …
Meta-Analysis
Prostaglandins & other …
2024
7 件の引用
Prostaglandins, leukotrienes, and …
2024
6 件の引用
Effect of Omega-3 Fatty Acid Supplementation on Periodontal Inflammation and Pocket Depth Reduction.
Other
Journal of pharmacy …
2024
1 件の引用
Advances in rheumatology …
2024
European review for …
2023
67 件の引用
A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation.
Review
Biochemistry and biophysics …
2023
66 件の引用
Cancer metastasis reviews
2023
28 件の引用
Brain, behavior, and …
2023
18 件の引用
Frontiers in nutrition
2023
17 件の引用
International immunopharmacology
2023
8 件の引用
Nutrients
2022
29 件の引用
Toxicology and applied …
2022
20 件の引用
Effect of omega-3 fatty acids on the telomere length: A mini meta-analysis of clinical trials.
Meta-Analysis
Biomolecular concepts
2022
18 件の引用
The American journal …
2022
1 件の引用
American heart journal …
2022
Do Eicosapentaenoic Acid and Docosahexaenoic Acid Have the Potential to Compete against Each Other?
Review
Nutrients
2020
50 件の引用
Reproductive medicine and …
2020
11 件の引用
Clinical nutrition (Edinburgh, …
2020
10 件の引用
Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis.
Other
Toxicology mechanisms and …
2019
33 件の引用
Effect of omega-3 fatty acid plus vitamin E Co-Supplementation on lipid profile: A systematic review and meta-analysis.
Meta-Analysis
Diabetes & metabolic …
2019
28 件の引用
Journal of renal …
2019
7 件の引用
Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids.
RCT
Prostaglandins, leukotrienes, and …
2018
38 件の引用
Frontiers in immunology
2017
74 件の引用
European journal of …
2016
102 件の引用
International journal of …
2016
56 件の引用
The association of dietary intake and supplementation of specific polyunsaturated fatty acids with inflammation and functional capacity in chronic obstructive …
Systematic Review
International journal of …
2016
20 件の引用
Clinical journal of …
2016
4 件の引用
Allergology international : …
2015
205 件の引用
Prostaglandins & other …
2015
182 件の引用
Blood cells, molecules …
2015
53 件の引用
Prostaglandins & other …
2015
35 件の引用
Journal of Alzheimer's …
2015
8 件の引用
European journal of …
2014
Nutrition research (New …
2013
90 件の引用
Acta medica Indonesiana
2011
37 件の引用
Journal of the …
2010
11 件の引用
Current atherosclerosis reports
2004
464 件の引用
Prevention of strokes.
Review
Current atherosclerosis reports
2001
2 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 250-500 mg combined EPA/DHA/day
- antiinflammatory:
- 1,000-3,000 mg combined EPA/DHA/day
上限量： 3,000 mg/day EPA+DHA (FDA-recognized as safe)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
推奨摂取タイミング： With meals
Safety & Side Effects
報告されている副作用
- ⚠ Fishy aftertaste and burping
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Increased bleeding risk at high doses
- ⚠ Potential LDL cholesterol increase at very high doses
既知の相互作用
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk)
- ● Blood pressure medications (additive blood pressure lowering)
- ● Orlistat (may reduce omega-3 absorption)
- ● Cyclosporine (may modify immunosuppressive effects)
耐容上限摂取量： 3,000 mg/day EPA+DHA (FDA-recognized as safe)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Omega-3 Fatty Acids (EPA/DHA) help with Chronic Inflammation?
Based on 30 studies with 30,000 participants, there is strong evidence from multiple clinical trials that Omega-3 Fatty Acids (EPA/DHA) may support Chronic Inflammation management. Our evidence grade is A (Strong Evidence).
How much Omega-3 Fatty Acids (EPA/DHA) should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 250-500 mg combined EPA/DHA/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids (EPA/DHA)?
Reported side effects may include Fishy aftertaste and burping, Gastrointestinal discomfort (nausea, diarrhea), Increased bleeding risk at high doses, Potential LDL cholesterol increase at very high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids (EPA/DHA) and Chronic Inflammation?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 30 peer-reviewed studies with 30,000 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Chronic Inflammation
Omega-3 Fatty Acids (EPA/DHA) 他の症状・状態について
References
- [1] Mahmut Bodur et al.. Mol Nutr Food Res. 2025. Immunomodulatory Effects of Omega-3 Fatty Acids: Mechanistic Insights and Health Implications. doi:10.1002/mnfr.202400752 PubMed
- [2] Vicente Javier Clemente-Suárez et al.. Nutrients. 2025. Impact of Vegan and Vegetarian Diets on Neurological Health: A Critical Review. doi:10.3390/nu17050884 PubMed
- [3] Charles N Serhan et al.. Annu Rev Physiol. 2025. Proresolving Lipid Mediators in the Respiratory System. doi:10.1146/annurev-physiol-020924-033209 PubMed
- [4] Marta Vomero et al.. Autoimmun Rev. 2025. Specialized pro-resolving mediators and autoimmunity: Recent insights and future perspectives. doi:10.1016/j.autrev.2025.103896 PubMed
- [5] Joanna Polom et al.. Nutrients. 2025. Employing Nutrition to Delay Aging: A Plant-Based Telomere-Friendly Dietary Revolution. doi:10.3390/nu17122004 PubMed
- [6] Ludmila Müller et al.. Front Immunol. 2025. Immunosenescence and inflammaging: Mechanisms and modulation through diet and lifestyle. doi:10.3389/fimmu.2025.1708280 PubMed
- [7] Stefania Lamon-Fava. Prostaglandins Other Lipid Mediat. 2025. Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with low-grade chronic inflammation. doi:10.1016/j.prostaglandins.2025.106948 PubMed
- [8] Hao Lin et al.. Lipids Health Dis. 2025. Association of omega-3, omega-6 fatty acids intakes and omega-6: omega-3 ratio with the prevalence of suicidal ideation: mediating role of … doi:10.1186/s12944-025-02587-6 PubMed
- [9] Larissa Parreira Araújo et al.. Int J Mol Sci. 2025. Sarcopenia in the Aging Process: Pathophysiological Mechanisms, Clinical Implications, and Emerging Therapeutic Approaches. doi:10.3390/ijms262412147 PubMed
- [10] Sanaz Jamshidi et al.. Nutrients. 2025. The Impact of Flavonoids and Omega-3 in Mitigating Frailty Syndrome to Improve Treatment Outcomes in Peripheral Artery Disease (PAD) Patients. doi:10.3390/nu17142303 PubMed
- [11] Jacques D Barth. Atherosclerosis. 2025. The omega effect: Harnessing fish oil for health. doi:10.1016/j.atherosclerosis.2025.120461 PubMed
- [12] Luigi Barrea et al.. Curr Obes Rep. 2025. Medical Nutrition Therapy in Dermatological Diseases: A Joint Consensus Statement of the Italian Association of Dietetics and Clinical Nutrition (ADI), … doi:10.1007/s13679-025-00630-2 PubMed
- [13] Khursheed Muzammil et al.. Prostaglandins Other Lipid Mediat. 2024. The effects of ω-3 fatty acids on inflammatory and oxidative stress markers in patients with Type 2 diabetes mellitus: A … doi:10.1016/j.prostaglandins.2024.106887 PubMed
- [14] Jisun So et al.. Prostaglandins Leukot Essent Fatty Acids. 2024. Sex differences in lipid mediators derived from omega-3 fatty acids in older individuals with low-grade chronic inflammation. doi:10.1016/j.plefa.2024.102655 PubMed
- [15] E M Arshad Ali et al.. J Pharm Bioallied Sci. 2024. Effect of Omega-3 Fatty Acid Supplementation on Periodontal Inflammation and Pocket Depth Reduction. doi:10.4103/jpbs.jpbs_1173_24 PubMed
- [16] Daniele Scherer et al.. Adv Rheumatol. 2024. Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial-the DIETA trial. doi:10.1186/s42358-024-00389-5 PubMed
- [17] R Poggioli et al.. Eur Rev Med Pharmacol Sci. 2023. Modulation of inflammation and immunity by omega-3 fatty acids: a possible role for prevention and to halt disease progression in … doi:10.26355/eurrev_202308_33310 PubMed
- [18] Seema Mehdi et al.. Biochem Biophys Rep. 2023. A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation. doi:10.1016/j.bbrep.2023.101571 PubMed
- [19] Charles N Serhan et al.. Cancer Metastasis Rev. 2023. Resolution medicine in cancer, infection, pain and inflammation: are we on track to address the next Pandemic? doi:10.1007/s10555-023-10091-5 PubMed
- [20] Jane Pei-Chen Chang et al.. Brain Behav Immun. 2023. Omega-3 polyunsaturated fatty acids (n-3 PUFAs), somatic and fatigue symptoms in cardiovascular diseases comorbid major depressive disorder (MDD): A randomized … doi:10.1016/j.bbi.2023.06.008 PubMed
- [21] Angélica Borja-Magno et al.. Front Nutr. 2023. Differential effects of high dose omega-3 fatty acids on metabolism and inflammation in patients with obesity: eicosapentaenoic and docosahexaenoic acid … doi:10.3389/fnut.2023.1156995 PubMed
- [22] Zhanwei Zhang et al.. Int Immunopharmacol. 2023. Maresin1: A multifunctional regulator in inflammatory bone diseases. doi:10.1016/j.intimp.2023.110308 PubMed
- [23] Yanbin Dong et al.. Nutrients. 2022. Effects of Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation on Biomarkers of Systemic Inflammation: 4-Year Findings from the VITAL … doi:10.3390/nu14245307 PubMed
- [24] Jeneen Panezai et al.. Toxicol Appl Pharmacol. 2022. Resolution of inflammation: Intervention strategies and future applications. doi:10.1016/j.taap.2022.116089 PubMed
- [25] Sawan Ali et al.. Biomol Concepts. 2022. Effect of omega-3 fatty acids on the telomere length: A mini meta-analysis of clinical trials. doi:10.1515/bmc-2021-0024 PubMed
- [26] Anthony D Pisaniello et al.. Am J Cardiol. 2022. Association Between Omega-3 Fatty Acid Levels and Aortic Valve Calcium (from the Multi-Ethnic Study of Atherosclerosis). doi:10.1016/j.amjcard.2022.08.026 PubMed
- [27] Ellen C Keeley et al.. Am Heart J Plus. 2022. Coronary microvascular dysfunction as a chronic inflammatory state: Is there a role for omega-3 fatty acid treatment? doi:10.1016/j.ahjo.2022.100098 PubMed
- [28] Anandita Pal et al.. Nutrients. 2020. Do Eicosapentaenoic Acid and Docosahexaenoic Acid Have the Potential to Compete against Each Other? doi:10.3390/nu12123718 PubMed
- [29] Fumitoshi Koga et al.. Reprod Med Biol. 2020. Relationship between nutrition and reproduction. doi:10.1002/rmb2.12332 PubMed
- [30] Kylie A Abbott et al.. Clin Nutr. 2020. Association between plasma phospholipid omega-3 polyunsaturated fatty acids and type 2 diabetes is sex dependent: The Hunter Community Study. doi:10.1016/j.clnu.2019.04.007 PubMed
- [31] Mohita Sharma et al.. Toxicol Mech Methods. 2019. Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis. doi:10.1080/15376516.2018.1553220 PubMed
- [32] Mahdi Sepidarkish et al.. Diabetes Metab Syndr. 2019. Effect of omega-3 fatty acid plus vitamin E Co-Supplementation on lipid profile: A systematic review and meta-analysis. doi:10.1016/j.dsx.2019.03.018 PubMed
- [33] Kenneth Yong et al.. J Ren Nutr. 2019. The Effects of OMEGA-3 Fatty Acid Supplementation Upon Interleukin-12 and Interleukin-18 in Chronic Kidney Disease Patients. doi:10.1053/j.jrn.2019.01.001 PubMed
- [34] Gregory C Shearer et al.. Prostaglandins Leukot Essent Fatty Acids. 2018. Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids. doi:10.1016/j.plefa.2017.10.006 PubMed
- [35] Robert A Whittington et al.. Front Immunol. 2017. Impaired Resolution of Inflammation in Alzheimer's Disease: A Review. doi:10.3389/fimmu.2017.01464 PubMed
- [36] Tim Y Hou et al.. Eur J Pharmacol. 2016. Omega-3 fatty acids, lipid rafts, and T cell signaling. doi:10.1016/j.ejphar.2015.03.091 PubMed
- [37] K Kaliannan et al.. Int J Obes (Lond). 2016. Omega-3 fatty acids prevent early-life antibiotic exposure-induced gut microbiota dysbiosis and later-life obesity. doi:10.1038/ijo.2016.27 PubMed
- [38] Evan Atlantis et al.. Int J Evid Based Healthc. 2016. The association of dietary intake and supplementation of specific polyunsaturated fatty acids with inflammation and functional capacity in chronic obstructive … doi:10.1097/XEB.0000000000000056 PubMed
- [39] Giacomo Garibotto et al.. Clin J Am Soc Nephrol. 2016. Studying Muscle Protein Turnover in CKD. doi:10.2215/CJN.04790516 PubMed
- [40] Jun Miyata et al.. Allergol Int. 2015. Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases. doi:10.1016/j.alit.2014.08.003 PubMed
- [41] Leyre Martínez-Fernández et al.. Prostaglandins Other Lipid Mediat. 2015. Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome. doi:10.1016/j.prostaglandins.2015.07.003 PubMed
- [42] Ahmed A Daak et al.. Blood Cells Mol Dis. 2015. Omega 3 (n-3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with … doi:10.1016/j.bcmd.2015.03.014 PubMed
- [43] Ann C Skulas-Ray. Prostaglandins Other Lipid Mediat. 2015. Omega-3 fatty acids and inflammation: a perspective on the challenges of evaluating efficacy in clinical research. doi:10.1016/j.prostaglandins.2015.02.001 PubMed
- [44] Milan Fiala et al.. J Alzheimers Dis. 2015. Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-β Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. doi:10.3233/JAD-150367 PubMed
- [45] Afshin Gharekhani et al.. Eur J Clin Pharmacol. 2014. The effect of omega-3 fatty acids on depressive symptoms and inflammatory markers in maintenance hemodialysis patients: a randomized, placebo-controlled clinical … doi:10.1007/s00228-014-1666-1 PubMed
- [46] Owen J Kelly et al.. Nutr Res. 2013. Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis. doi:10.1016/j.nutres.2013.04.012 PubMed
- [47] Wardhana et al.. Acta Med Indones. 2011. The role of omega-3 fatty acids contained in olive oil on chronic inflammation. PubMed
- [48] Linda A Linday. J Am Coll Nutr. 2010. Cod liver oil, young children, and upper respiratory tract infections. doi:10.1080/07315724.2010.10719894 PubMed
- [49] Trevor A Mori et al.. Curr Atheroscler Rep. 2004. Omega-3 fatty acids and inflammation. doi:10.1007/s11883-004-0087-5 PubMed
- [50] T J Jeerakathil et al.. Curr Atheroscler Rep. 2001. Prevention of strokes. doi:10.1007/s11883-001-0026-7 PubMed
- [51] D A Troyer et al.. Age (Omaha). 1998. Effects of calorie restriction and ω-3 dietary fat on aging in short-and long-lived rodents. doi:10.1007/s11357-998-0026-4 PubMed
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