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ImmuneCited

Arginine الأشكال

38 أشكال من أبحاث محكّمة

الكل Pelargonium sidoides Glutathione N-Acetylcysteine Astragalus Conjugated Linoleic Acid Curcumin Arginine Astaxanthin Cordyceps Omega-3 Fatty Acids (EPA/DHA) Zinc Quercetin Elderberry Resveratrol Vitamin D Andrographis Iron
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Figure 2. Phases and specific events of the wound healing process.
Figure 6 Diagram

Sequential phases of the wound healing process - hemostasis, inflammation, proliferation, and remodeling - and their specific cellular events are illustrated.

Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of …

Figure 3. Structure and effects of curcumin on wound healing.
Figure 7 Diagram

Chemical structure of curcumin alongside its documented effects on wound healing, including anti-inflammatory, antioxidant, and antimicrobial activities, are presented.

Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of …

Figure 6
Figure 6 Flowchart

PRISMA flow diagram details the screening and selection process for studies on glutamine supplementation and wound healing. From the initial database search, studies were filtered through title screening, abstract review, and full-text assessment.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 7
Figure 7

Characteristics of included studies on arginine supplementation for wound healing are summarized in tabular form. The table captures study design, participant demographics, dosage protocols, and primary outcome measures across the selected trials.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 3. Metabolism of glutamine to arginine in human macrophages. Carbamoyl phosphate when combined with ornithine via OTC is converted to citrulline. Then citrulline is transformed into argininosuccinate and then into arginine by the action of ASS and
Figure 8 Diagram

Glutamine-to-arginine metabolism in human macrophages is mapped, showing the conversion of carbamoyl phosphate and ornithine to citrulline via ornithine transcarbamylase, and subsequent transformation to argininosuccinate. This pathway is central to understanding how glutamine supports immune-mediated wound repair.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 9
Figure 9

Study characteristics for the glutamine supplementation arm of the systematic review are presented. The compilation enables cross-study comparison of dosing regimens, wound types, and healing outcomes measured in human trials.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 10
Figure 10 Chart

Risk of bias assessment for arginine studies is displayed using the Cochrane tool framework. Each domain of potential bias is evaluated across the included trials to gauge the overall quality of evidence supporting arginine supplementation for wound healing.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 11
Figure 11 Chart

Risk of bias assessment for glutamine studies complements the arginine evaluation. The systematic assessment of selection, performance, detection, attrition, and reporting bias helps contextualize the strength of conclusions about glutamine and wound repair.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 4. Flow diagram of the search strategy for arginine.
Figure 12 Flowchart

The PRISMA flow diagram for the arginine search strategy traces article identification through database queries, duplicate removal, and eligibility screening. Five human studies on arginine supplementation and wound healing met the final inclusion criteria.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 6. Risk of bias summary for the included studies on arginine. Low risk of bias (+), unclear risk of bias (?), and high risk of bias (−).
Figure 13 Chart

Risk of bias is summarized for each included arginine study using green (low risk), yellow (unclear), and red (high risk) indicators. The visual matrix helps readers quickly assess methodological quality across randomization, blinding, and outcome reporting domains.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 7. Risk of bias summary for the included studies on glutamine. Low risk of bias (+), unclear risk of bias (?), and high risk of bias ( ).
Figure 14 Chart

Risk of bias for the included glutamine studies follows the same Cochrane framework, with symbols indicating low, unclear, and high risk across multiple domains. The assessment covers 39 human studies evaluating glutamine supplementation effects on wound healing.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 8. Hydroxyproline content: fixed-effects meta-analysis and forest plot from studies providing supplementation of arginine.
Figure 15 Forest Plot

A fixed-effects meta-analysis forest plot displays the effect of arginine supplementation on hydroxyproline content, a biomarker of collagen synthesis in wound tissue. Individual study effect sizes and confidence intervals are pooled to estimate the overall treatment effect.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 9. Nitrogen balance: fixed-effects meta-analysis and forest plot from studies providing supplementation of glutamine.
Figure 16 Forest Plot

Nitrogen balance outcomes from glutamine supplementation studies are combined in a fixed-effects forest plot. Positive nitrogen balance indicates enhanced protein retention, which is associated with improved wound healing capacity in stressed or surgical patients.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 10. Length of hospital stay: fixed-effects meta-analysis and forest plot from studies providing supplementation of glutamine.
Figure 17 Forest Plot

Length of hospital stay is analyzed in a fixed-effects meta-analysis forest plot for glutamine supplementation trials. The pooled estimate indicates whether glutamine may reduce recovery time in patients with wounds requiring hospitalization.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 18
Figure 18 Forest Plot

Additional meta-analysis results for glutamine supplementation and wound healing outcomes are presented. The analysis extends the evidence base by examining secondary endpoints across the included clinical trials.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 19
Figure 19 Forest Plot

Supplementary forest plot data from the glutamine meta-analysis displays effect estimates for an additional wound healing outcome. Confidence intervals for individual studies and the pooled effect are shown.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 13. C-reactive protein: fixed-effects meta-analysis and forest plot from studies providing supplementation of glutamine.
Figure 20 Forest Plot

C-reactive protein levels following glutamine supplementation are pooled in a fixed-effects forest plot. Lower CRP values suggest reduced systemic inflammation, which may contribute to improved wound healing outcomes.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 21
Figure 21 Forest Plot

An additional inflammatory or immune marker from the glutamine meta-analysis is displayed in forest plot format. The pooled analysis evaluates whether glutamine supplementation modulates immune parameters relevant to wound repair.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 22
Figure 22 Forest Plot

Further meta-analysis results present pooled effect sizes for wound healing parameters in glutamine-supplemented patients. The forest plot format allows visual comparison of effect magnitude and consistency across trials.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 15. T-cell lymphocytes: fixed-effects meta-analysis and forest plot from studies providing supplementation of glutamine.
Figure 23 Forest Plot

T-cell lymphocyte counts are analyzed in a fixed-effects forest plot across glutamine supplementation trials. Enhanced T-cell proliferation is associated with improved immune-mediated wound repair, and the pooled estimate evaluates glutamine's immunomodulatory potential.

The Effect of Amino Acids on Wound Healing: A Systematic Review and …

Figure 3
Figure 3 Chart

Rheological and mechanical characterization of the click chemistry hydrogel demonstrates properties suitable for 3D bioprinting. The material's shear-thinning behavior and rapid recovery enable precise deposition of cell-laden constructs.

A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing.

Figure 4
Figure 4 Photograph

Bioprinting parameters and construct fidelity are evaluated for the peptide hydrogel system. The printability assessment confirms that the material maintains structural integrity while supporting embedded vascular endothelial cell viability.

A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing.

Figure 5
Figure 5 Micrograph

VEGF165-overexpressing endothelial cells encapsulated within the hydrogel are assessed for viability and vascular network formation. The growth factor expression aims to promote angiogenesis, addressing the vascular injury central to non-healing diabetic wounds.

A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing.

Figure 6
Figure 6 Micrograph

In vitro wound healing assays using the bioprinted hydrogel constructs demonstrate enhanced cell migration and proliferation. The results suggest that the all-peptide platform supports the cellular processes required for tissue regeneration.

A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing.

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