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Figure 3. Metabolism of glutamine to arginine in human macrophages. Carbamoyl phosphate when combined with ornithine via OTC is converted to citrulline. Then citrulline is transformed into argininosuccinate and then into arginine by the action of ASS and
Figure 8. Figure 3. Metabolism of glutamine to arginine in human macrophages. Carbamoyl phosphate when combined with ornithine via OTC is converted to citrulline. Then citrulline is transformed into argininosuccinate and then into arginine by the action of ASS and ASL, respectively. Arginine can then be turned into nitric oxide or ornithine. Ornithine can be transformed into glutamine, and vice versa, via glutamate and pyrroline-5-carboxylate.

الوصف

Glutamine-to-arginine metabolism in human macrophages is mapped, showing the conversion of carbamoyl phosphate and ornithine to citrulline via ornithine transcarbamylase, and subsequent transformation to argininosuccinate. This pathway is central to understanding how glutamine supports immune-mediated wound repair.

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PRISMA flow diagram details the screening and selection process for studies on glutamine supplementation and wound healing. From the initial database search, studies were filtered through title screening, abstract review, and full-text assessment.

Figure 6

PRISMA flow diagram details the screening and selection process for studies on glutamine supplementation and wound healing. From the initial database search, studies were filtered through title screening, abstract review, and full-text assessment.

flowchart
Characteristics of included studies on arginine supplementation for wound healing are summarized in tabular form. The table captures study design, participant demographics, dosage protocols, and primary outcome measures across the selected trials.

Figure 7

Characteristics of included studies on arginine supplementation for wound healing are summarized in tabular form. The table captures study design, participant demographics, dosage protocols, and primary outcome measures across the selected trials.
Study characteristics for the glutamine supplementation arm of the systematic review are presented. The compilation enables cross-study comparison of dosing regimens, wound types, and healing outcomes measured in human trials.

Figure 9

Study characteristics for the glutamine supplementation arm of the systematic review are presented. The compilation enables cross-study comparison of dosing regimens, wound types, and healing outcomes measured in human trials.
Risk of bias assessment for arginine studies is displayed using the Cochrane tool framework. Each domain of potential bias is evaluated across the included trials to gauge the overall quality of evidence supporting arginine supplementation for wound healing.

Figure 10

Risk of bias assessment for arginine studies is displayed using the Cochrane tool framework. Each domain of potential bias is evaluated across the included trials to gauge the overall quality of evidence supporting arginine supplementation for wound healing.

chart
Risk of bias assessment for glutamine studies complements the arginine evaluation. The systematic assessment of selection, performance, detection, attrition, and reporting bias helps contextualize the strength of conclusions about glutamine and wound repair.

Figure 11

Risk of bias assessment for glutamine studies complements the arginine evaluation. The systematic assessment of selection, performance, detection, attrition, and reporting bias helps contextualize the strength of conclusions about glutamine and wound repair.

chart
The PRISMA flow diagram for the arginine search strategy traces article identification through database queries, duplicate removal, and eligibility screening. Five human studies on arginine supplementation and wound healing met the final inclusion criteria.

Figure 12

The PRISMA flow diagram for the arginine search strategy traces article identification through database queries, duplicate removal, and eligibility screening. Five human studies on arginine supplementation and wound healing met the final inclusion criteria.

flowchart

Figure 8

Diagram
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Source Paper

The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine.

Nutrients (2021)

PMID: 34444657

DOI: 10.3390/nu13082498

Cite This Figure

![Figure 8: Glutamine-to-arginine metabolism in human macrophages is mapped, showing the conversion of carbamoyl phosphate and ornithine to citrulline via ornithine transcarbamylase, and subsequent transformation to argininosuccinate. This pathway is central to understanding how glutamine supports immune-mediated wound repair.](https://pdfs.citedhealth.com/figures/34444657/116.png)

> Source: Elena Arribas-López et al. "The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysi." *Nutrients*, 2021. PMID: [34444657](https://pubmed.ncbi.nlm.nih.gov/34444657/)
<figure>
  <img src="https://pdfs.citedhealth.com/figures/34444657/116.png" alt="Glutamine-to-arginine metabolism in human macrophages is mapped, showing the conversion of carbamoyl phosphate and ornithine to citrulline via ornithine transcarbamylase, and subsequent transformation to argininosuccinate. This pathway is central to understanding how glutamine supports immune-mediated wound repair." />
  <figcaption>Figure 8. Glutamine-to-arginine metabolism in human macrophages is mapped, showing the conversion of carbamoyl phosphate and ornithine to citrulline via ornithine transcarbamylase, and subsequent transformation to argininosuccinate. This pathway is central to understanding how glutamine supports immune-mediated wound repair.<br>  Source: Elena Arribas-López et al. "The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysi." <em>Nutrients</em>, 2021. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/34444657/">34444657</a></figcaption>
</figure>

أدلة ذات صلة

B
Arginine لـ Wound Healing and Immune Recovery

التقييم B · 8 دراسات