Arginine لـ Wound Healing and Immune Recovery

Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.

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الخلاصة

Key Study Findings

Systematic Review n=1085

The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.

Dose: None مقابل: Standard care or placebo Outcome: Wound healing time and wound size reduction التأثير: Wound size reduction 18.6-98.2% over 2-20 weeks None

المجتمع المدروس: Adults with pressure ulcers (15 studies)

Other

PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.

Dose: None مقابل: Wild-type mice and control HCECs Outcome: Corneal epithelial wound healing التأثير: None None

المجتمع المدروس: Murine corneal wound model and human corneal cells

In Vitro

Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.

Dose: None مقابل: None Outcome: Diabetic wound healing التأثير: None None

المجتمع المدروس: Diabetic wound model

In Vitro

Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis.

Dose: None مقابل: None Outcome: Diabetic wound healing التأثير: None None

المجتمع المدروس: Diabetic wound animal model

Other

Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing.

Dose: None مقابل: Untreated diabetic wound controls Outcome: Diabetic wound healing via angiogenesis التأثير: None None

المجتمع المدروس: Diabetic ulcer mice model

Other

Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5.

Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: Diabetes patients

Key Statistics

الدراسات

600

المشاركون

↑

Positive

التقييم

Referenced Papers

Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis. Other

Journal of controlled … 2025 16 اقتباسات

Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing. Other

Journal of colloid … 2025 8 اقتباسات

PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3. Other

Investigative ophthalmology & … 2025 4 اقتباسات

The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review. Systematic Review

Wound repair and … 2025 2 اقتباسات

Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing. Other

ACS applied materials … 2024 27 اقتباسات

Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5. Other

Advanced science (Weinheim, … 2024 15 اقتباسات

Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review. Systematic Review

Nutrition (Burbank, Los … 2024 12 اقتباسات

l-Arginine-Loaded Oxidized Isabgol/Chitosan-Based Biomimetic Composite Scaffold Accelerates Collagen Synthesis, Vascularization, and Re-epithelialization during Wound Healing in Diabetic Rats. Other

ACS applied bio … 2024 4 اقتباسات

Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes. Other

Molecular metabolism 2024 3 اقتباسات

Effectiveness of glutamine and arginine in wound healing of pressure ulcers: A systematic review protocol. Other

Journal of tissue … 2024 2 اقتباسات

Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing. Other

ACS nano 2023 237 اقتباسات

A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing. Other

Nature communications 2023 120 اقتباسات

Preparation and evaluation of a novel alginate-arginine-zinc ion hydrogel film for skin wound healing. Other

Carbohydrate polymers 2023 86 اقتباسات

Neutrophil Extracellular Traps Delay Diabetic Wound Healing by Inducing Endothelial-to-Mesenchymal Transition via the Hippo pathway. Other

International journal of … 2023 76 اقتباسات

Antibacterial self-healing bilayer dressing for epidermal sensors and accelerate wound repair. Other

Carbohydrate polymers 2023 32 اقتباسات

A phellinus igniarius polysaccharide/chitosan-arginine hydrogel for promoting diabetic wound healing. Other

International journal of … 2023 31 اقتباسات

Microarray needles comprised of arginine-modified chitosan/PVA hydrogel for enhanced antibacterial and wound healing potential of curcumin. Other

International journal of … 2023 27 اقتباسات

Tannic acid-loaded chitosan-RGD-alginate scaffolds for wound healing and skin regeneration. Other

Biomedical materials (Bristol, … 2023 15 اقتباسات

Protein Arginine Methyltransferases Refine the Classification of Clear Cell Renal Cell Carcinoma with Distinct Prognosis and Tumor Microenvironment Characteristics. Other

International journal of … 2023 11 اقتباسات

Keratin-based wound dressings: From waste to wealth. Review

International journal of … 2022 77 اقتباسات

A Systematic Review of Oral Nutritional Supplement and Wound Healing. Systematic Review

The Annals of … 2022 31 اقتباسات

Effects of arginine glutamate (RE:pair) on wound healing and skin elasticity improvement after CO2 laser irradiation. Other

Journal of cosmetic … 2022 10 اقتباسات

The use of oral and enteral tube-fed arginine supplementation in pressure injury care: A systematic review and meta-analysis. Meta-Analysis

Nursing open 2022 9 اقتباسات

Arginine methylation in the epithelial-to-mesenchymal transition. Review

The FEBS journal 2022 8 اقتباسات

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Other

Advances in experimental … 2021 206 اقتباسات

The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine. Meta-Analysis

Nutrients 2021 123 اقتباسات

Advances and impact of arginine-based materials in wound healing. Review

Journal of materials … 2021 36 اقتباسات

[Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot]. Other

Nutricion hospitalaria 2021 20 اقتباسات

Nutritional interventions for treating foot ulcers in people with diabetes. Meta-Analysis

The Cochrane database … 2020 33 اقتباسات

Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. Review

International journal of … 2019 265 اقتباسات

Effectiveness of Arginine Supplementation on Wound Healing in Older Adults in Acute and Chronic Settings: A Systematic Review. Systematic Review

Advances in skin … 2019 18 اقتباسات

Arginine Silicate Inositol Complex Accelerates Cutaneous Wound Healing. Other

Biological trace element … 2017 10 اقتباسات

When Is It Appropriate to Use Arginine in Critical Illness? Review

Nutrition in clinical … 2016 42 اقتباسات

A nutritional formula enriched with arginine, zinc, and antioxidants for the healing of pressure ulcers: a randomized trial. RCT

Annals of internal … 2015 110 اقتباسات

Nutrition optimization prior to surgery. Review

Nutrition in clinical … 2014 131 اقتباسات

M1 and M2 Macrophages: Oracles of Health and Disease. Review

Critical reviews in … 2012 969 اقتباسات

Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies. Review

Current opinion in … 2009 66 اقتباسات

Assessment and nutritional aspects of wound healing. Review

Current opinion in … 2008 240 اقتباسات

Nutrition and wound healing. Review

Plastic and reconstructive … 2006 98 اقتباسات

Arginine supplementation and wound healing. Review

Nutrition in clinical … 2005 247 اقتباسات

Arginine and cancer. Review

The Journal of … 2004 181 اقتباسات

Cellular and physiological effects of arginine. Review

Mini reviews in … 2004 178 اقتباسات

Arginine physiology and its implication for wound healing. Review

Wound repair and … 2003 306 اقتباسات

Nutrition and wound healing. Review

The Surgical clinics … 2003 16 اقتباسات

Nutritional support for wound healing. Review

Alternative medicine review … 2003

Arginine and wound healing. Other

Advances in skin … 2001 10 اقتباسات

Cytokines and L-arginine in renal injury and repair. Review

The American journal … 1994 91 اقتباسات

Nutrition and wound healing. Review

JPEN. Journal of … 1994 72 اقتباسات

Arginine enhances wound healing and lymphocyte immune responses in humans. RCT

Surgery 1990

Wound healing and thymotropic effects of arginine: a pituitary mechanism of action. Other

The American journal … 1983 135 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:: 2-3 g/day
immunesupport:: 6-9 g/day

الحد الأعلى: No established UL; typically tolerated at 20 g/day

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
None	--	Positive	1085
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Negative	--
None	--	Positive	--

أفضل وقت للتناول: Between meals

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Gastrointestinal discomfort (bloating, diarrhea, cramps)
⚠ Gout exacerbation (increased uric acid production)
⚠ Blood pressure changes
⚠ Worsening of herpes outbreaks (arginine supports viral replication)

التفاعلات المعروفة

● Antihypertensive medications (additive blood pressure lowering)
● PDE5 inhibitors like sildenafil (additive vasodilation)
● Anticoagulants (may affect platelet function)
● Potassium-sparing diuretics (arginine may increase potassium levels)

الحد الأقصى المسموح به: No established UL; typically tolerated at 20 g/day

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Arginine help with Wound Healing and Immune Recovery?

Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Arginine may support Wound Healing and Immune Recovery management. Our evidence grade is B (Good Evidence).

How much Arginine should I take for Wound Healing and Immune Recovery?

Studies have used various dosages. A commonly studied range is 2-3 g/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Arginine?

Reported side effects may include Gastrointestinal discomfort (bloating, diarrhea, cramps), Gout exacerbation (increased uric acid production), Blood pressure changes, Worsening of herpes outbreaks (arginine supports viral replication). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Arginine and Wound Healing and Immune Recovery?

We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

الخلاصة السريعة

Evidence Strength72%

High confidence

تفصيل الدراسات

RCT (2)Meta (3)Other (3)

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اعرف المزيد

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.