Arginine 관련 Wound Healing and Immune Recovery
BArginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.
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B
결론
Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.
Key Study Findings
Systematic Review
n=1085
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Dose: None
vs: Standard care or placebo
Outcome: Wound healing time and wound size reduction
효과: Wound size reduction 18.6-98.2% over 2-20 weeks
None
대상 집단: Adults with pressure ulcers (15 studies)
Other
PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.
Dose: None
vs: Wild-type mice and control HCECs
Outcome: Corneal epithelial wound healing
효과: None
None
대상 집단: Murine corneal wound model and human corneal cells
In Vitro
Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.
Dose: None
vs: None
Outcome: Diabetic wound healing
효과: None
None
대상 집단: Diabetic wound model
In Vitro
Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis.
Dose: None
vs: None
Outcome: Diabetic wound healing
효과: None
None
대상 집단: Diabetic wound animal model
Other
Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing.
Dose: None
vs: Untreated diabetic wound controls
Outcome: Diabetic wound healing via angiogenesis
효과: None
None
대상 집단: Diabetic ulcer mice model
Other
Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5.
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: Diabetes patients
Key Statistics
8
연구
600
참여자
↑
Positive
B
등급
Referenced Papers
Journal of controlled …
2025
16 인용
Journal of colloid …
2025
8 인용
Investigative ophthalmology & …
2025
4 인용
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Systematic Review
Wound repair and …
2025
2 인용
ACS applied materials …
2024
27 인용
Advanced science (Weinheim, …
2024
15 인용
Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review.
Systematic Review
Nutrition (Burbank, Los …
2024
12 인용
ACS applied bio …
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4 인용
Molecular metabolism
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3 인용
Journal of tissue …
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2 인용
Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing.
Other
ACS nano
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237 인용
A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing.
Other
Nature communications
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120 인용
Carbohydrate polymers
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86 인용
International journal of …
2023
76 인용
Antibacterial self-healing bilayer dressing for epidermal sensors and accelerate wound repair.
Other
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11 인용
International journal of …
2022
77 인용
A Systematic Review of Oral Nutritional Supplement and Wound Healing.
Systematic Review
The Annals of …
2022
31 인용
Journal of cosmetic …
2022
10 인용
The use of oral and enteral tube-fed arginine supplementation in pressure injury care: A systematic review and meta-analysis.
Meta-Analysis
Nursing open
2022
9 인용
The FEBS journal
2022
8 인용
Advances in experimental …
2021
206 인용
The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine.
Meta-Analysis
Nutrients
2021
123 인용
Journal of materials …
2021
36 인용
Nutricion hospitalaria
2021
20 인용
The Cochrane database …
2020
33 인용
International journal of …
2019
265 인용
Effectiveness of Arginine Supplementation on Wound Healing in Older Adults in Acute and Chronic Settings: A Systematic Review.
Systematic Review
Advances in skin …
2019
18 인용
Biological trace element …
2017
10 인용
Nutrition in clinical …
2016
42 인용
Annals of internal …
2015
110 인용
Nutrition in clinical …
2014
131 인용
Critical reviews in …
2012
969 인용
Current opinion in …
2009
66 인용
Current opinion in …
2008
240 인용
Nutrition and wound healing.
Review
Plastic and reconstructive …
2006
98 인용
Nutrition in clinical …
2005
247 인용
Arginine and cancer.
Review
The Journal of …
2004
181 인용
Mini reviews in …
2004
178 인용
Wound repair and …
2003
306 인용
Nutrition and wound healing.
Review
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2003
16 인용
Alternative medicine review …
2003
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2001
10 인용
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Review
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135 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 2-3 g/day
- immunesupport:
- 6-9 g/day
상한량: No established UL; typically tolerated at 20 g/day
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Positive | 1085 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Negative | -- |
| None | -- | Positive | -- |
권장 복용 시간: Between meals
Safety & Side Effects
보고된 부작용
- ⚠ Gastrointestinal discomfort (bloating, diarrhea, cramps)
- ⚠ Gout exacerbation (increased uric acid production)
- ⚠ Blood pressure changes
- ⚠ Worsening of herpes outbreaks (arginine supports viral replication)
알려진 상호작용
- ● Antihypertensive medications (additive blood pressure lowering)
- ● PDE5 inhibitors like sildenafil (additive vasodilation)
- ● Anticoagulants (may affect platelet function)
- ● Potassium-sparing diuretics (arginine may increase potassium levels)
일일 최대 섭취 허용량: No established UL; typically tolerated at 20 g/day
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Arginine help with Wound Healing and Immune Recovery?
Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Arginine may support Wound Healing and Immune Recovery management. Our evidence grade is B (Good Evidence).
How much Arginine should I take for Wound Healing and Immune Recovery?
Studies have used various dosages. A commonly studied range is 2-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Arginine?
Reported side effects may include Gastrointestinal discomfort (bloating, diarrhea, cramps), Gout exacerbation (increased uric acid production), Blood pressure changes, Worsening of herpes outbreaks (arginine supports viral replication). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Arginine and Wound Healing and Immune Recovery?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.