N-아세틸시스테인 관련 상처 치유 및 면역 회복
B 근거 적어도 하나의 무작위 시험이 이를 지지하며, 대체로 일관된 결과를 보입니다.Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.
결론
Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.
Key Study Findings
대상 집단: Adults with pressure ulcers (15 studies)
대상 집단: Murine corneal wound model and human corneal cells
대상 집단: Diabetic wound model
대상 집단: Diabetic wound animal model
대상 집단: Diabetic ulcer mice model
대상 집단: Diabetes patients
Key Statistics
8
연구
600
참여자
Positive
등급
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 2-3 g/day
- immunesupport:
- 6-9 g/day
상한량: No established UL; typically tolerated at 20 g/day
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Positive | 1085 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Negative | -- |
| None | -- | Positive | -- |
권장 복용 시간: Between meals
Safety & Side Effects
보고된 부작용
- ⚠ Gastrointestinal discomfort (bloating, diarrhea, cramps)
- ⚠ Gout exacerbation (increased uric acid production)
- ⚠ Blood pressure changes
- ⚠ Worsening of herpes outbreaks (arginine supports viral replication)
알려진 상호작용
- ● Antihypertensive medications (additive blood pressure lowering)
- ● PDE5 inhibitors like sildenafil (additive vasodilation)
- ● Anticoagulants (may affect platelet function)
- ● Potassium-sparing diuretics (arginine may increase potassium levels)
일일 최대 섭취 허용량: No established UL; typically tolerated at 20 g/day
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does N-아세틸시스테인 help with 상처 치유 및 면역 회복?
How much N-아세틸시스테인 should I take for 상처 치유 및 면역 회복?
Are there side effects of N-아세틸시스테인?
How strong is the evidence for N-아세틸시스테인 and 상처 치유 및 면역 회복?
References
- [1] Fupeng Li et al.. J Control Release. 2025. Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis. doi:10.1016/j.jconrel.2025.113838 PubMed
- [2] Jialiang Pan et al.. J Colloid Interface Sci. 2025. Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing. doi:10.1016/j.jcis.2025.138423 PubMed
- [3] Qiongjie Cao et al.. Invest Ophthalmol Vis Sci. 2025. PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3. doi:10.1167/iovs.66.1.22 PubMed
- [4] Tim Torsy et al.. Wound Repair Regen. 2025. The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review. doi:10.1111/wrr.70077 PubMed
- [5] Yan Yang et al.. ACS Appl Mater Interfaces. 2024. Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing. doi:10.1021/acsami.3c13072 PubMed
- [6] Qian Zhang et al.. Adv Sci (Weinh). 2024. Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5. doi:10.1002/advs.202405987 PubMed
- [7] Allan Carlos Soares do Espírito Santo et al.. Nutrition. 2024. Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review. doi:10.1016/j.nut.2024.112449 PubMed
- [8] Iniyan Saravanakumar et al.. ACS Appl Bio Mater. 2024. l-Arginine-Loaded Oxidized Isabgol/Chitosan-Based Biomimetic Composite Scaffold Accelerates Collagen Synthesis, Vascularization, and Re-epithelialization during Wound Healing in Diabetic Rats. doi:10.1021/acsabm.4c00729 PubMed
- [9] Ammar A Abdelrahman et al.. Mol Metab. 2024. Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes. doi:10.1016/j.molmet.2024.102020 PubMed
- [10] Tim Torsy et al.. J Tissue Viability. 2024. Effectiveness of glutamine and arginine in wound healing of pressure ulcers: A systematic review protocol. doi:10.1016/j.jtv.2024.03.001 PubMed
- [11] Limin Shang et al.. ACS Nano. 2023. Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing. doi:10.1021/acsnano.3c04134 PubMed
- [12] Jinjian Huang et al.. Nat Commun. 2023. A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing. doi:10.1038/s41467-023-43364-2 PubMed
- [13] Ganzhe Mao et al.. Carbohydr Polym. 2023. Preparation and evaluation of a novel alginate-arginine-zinc ion hydrogel film for skin wound healing. doi:10.1016/j.carbpol.2023.120757 PubMed
- [14] Shuofei Yang et al.. Int J Biol Sci. 2023. Neutrophil Extracellular Traps Delay Diabetic Wound Healing by Inducing Endothelial-to-Mesenchymal Transition via the Hippo pathway. doi:10.7150/ijbs.78046 PubMed
- [15] Asghar Eskandarinia et al.. Carbohydr Polym. 2023. Antibacterial self-healing bilayer dressing for epidermal sensors and accelerate wound repair. doi:10.1016/j.carbpol.2023.121171 PubMed
- [16] Lifeng Zhang et al.. Int J Biol Macromol. 2023. A phellinus igniarius polysaccharide/chitosan-arginine hydrogel for promoting diabetic wound healing. doi:10.1016/j.ijbiomac.2023.126014 PubMed
- [17] Muhammad Hasnain et al.. Int J Biol Macromol. 2023. Microarray needles comprised of arginine-modified chitosan/PVA hydrogel for enhanced antibacterial and wound healing potential of curcumin. doi:10.1016/j.ijbiomac.2023.126697 PubMed
- [18] Hillary Mndlovu et al.. Biomed Mater. 2023. Tannic acid-loaded chitosan-RGD-alginate scaffolds for wound healing and skin regeneration. doi:10.1088/1748-605X/acce88 PubMed
- [19] Shiqi Ye et al.. Int J Biol Sci. 2023. Protein Arginine Methyltransferases Refine the Classification of Clear Cell Renal Cell Carcinoma with Distinct Prognosis and Tumor Microenvironment Characteristics. doi:10.7150/ijbs.80323 PubMed
- [20] Wenjin Ye et al.. Int J Biol Macromol. 2022. Keratin-based wound dressings: From waste to wealth. doi:10.1016/j.ijbiomac.2022.04.216 PubMed
- [21] Ghazal S Daher et al.. Ann Otol Rhinol Laryngol. 2022. A Systematic Review of Oral Nutritional Supplement and Wound Healing. doi:10.1177/00034894211069437 PubMed
- [22] Koo Chul Kwon et al.. J Cosmet Dermatol. 2022. Effects of arginine glutamate (RE:pair) on wound healing and skin elasticity improvement after CO2 laser irradiation. doi:10.1111/jocd.14957 PubMed
- [23] Sahar Cheshmeh et al.. Nurs Open. 2022. The use of oral and enteral tube-fed arginine supplementation in pressure injury care: A systematic review and meta-analysis. doi:10.1002/nop2.974 PubMed
- [24] Jian Qin et al.. FEBS J. 2022. Arginine methylation in the epithelial-to-mesenchymal transition. doi:10.1111/febs.16152 PubMed
- [25] Guoyao Wu et al.. Adv Exp Med Biol. 2021. Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. doi:10.1007/978-3-030-74180-8_10 PubMed
- [26] Elena Arribas-López et al.. Nutrients. 2021. The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine. doi:10.3390/nu13082498 PubMed
- [27] Yang Zhou et al.. J Mater Chem B. 2021. Advances and impact of arginine-based materials in wound healing. doi:10.1039/d1tb00958c PubMed
- [28] Rosa María Martínez García et al.. Nutr Hosp. 2021. [Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot]. doi:10.20960/nh.03800 PubMed
- [29] Zena Eh Moore et al.. Cochrane Database Syst Rev. 2020. Nutritional interventions for treating foot ulcers in people with diabetes. doi:10.1002/14651858.CD011378.pub2 PubMed
- [30] Martina Barchitta et al.. Int J Mol Sci. 2019. Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. doi:10.3390/ijms20051119 PubMed
- [31] Kara L Schneider et al.. Adv Skin Wound Care. 2019. Effectiveness of Arginine Supplementation on Wound Healing in Older Adults in Acute and Chronic Settings: A Systematic Review. doi:10.1097/01.ASW.0000579700.20404.56 PubMed
- [32] Ali Said Durmus et al.. Biol Trace Elem Res. 2017. Arginine Silicate Inositol Complex Accelerates Cutaneous Wound Healing. doi:10.1007/s12011-016-0857-2 PubMed
- [33] Jayshil J Patel et al.. Nutr Clin Pract. 2016. When Is It Appropriate to Use Arginine in Critical Illness? doi:10.1177/0884533616652576 PubMed
- [34] Emanuele Cereda et al.. Ann Intern Med. 2015. A nutritional formula enriched with arginine, zinc, and antioxidants for the healing of pressure ulcers: a randomized trial. doi:10.7326/M14-0696 PubMed
- [35] David C Evans et al.. Nutr Clin Pract. 2014. Nutrition optimization prior to surgery. doi:10.1177/0884533613517006 PubMed
- [36] Charles D Mills. Crit Rev Immunol. 2012. M1 and M2 Macrophages: Oracles of Health and Disease. doi:10.1615/critrevimmunol.v32.i6.10 PubMed
- [37] Sabine Ellinger et al.. Curr Opin Clin Nutr Metab Care. 2009. Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies. doi:10.1097/MCO.0b013e328331a5b5 PubMed
- [38] Antonio C L Campos et al.. Curr Opin Clin Nutr Metab Care. 2008. Assessment and nutritional aspects of wound healing. doi:10.1097/MCO.0b013e3282fbd35a PubMed
- [39] Meghan Arnold et al.. Plast Reconstr Surg. 2006. Nutrition and wound healing. doi:10.1097/01.prs.0000225432.17501.6c PubMed
- [40] Joyce K Stechmiller et al.. Nutr Clin Pract. 2005. Arginine supplementation and wound healing. doi:10.1177/011542650502000152 PubMed
- [41] D Scott Lind. J Nutr. 2004. Arginine and cancer. doi:10.1093/jn/134.10.2837S PubMed
- [42] Betty C Tong et al.. Mini Rev Med Chem. 2004. Cellular and physiological effects of arginine. doi:10.2174/1389557043403305 PubMed
- [43] Maria B Witte et al.. Wound Repair Regen. 2003. Arginine physiology and its implication for wound healing. doi:10.1046/j.1524-475x.2003.11605.x PubMed
- [44] Jeremy Z Williams et al.. Surg Clin North Am. 2003. Nutrition and wound healing. doi:10.1016/S0039-6109(02)00193-7 PubMed
- [45] Douglas MacKay et al.. Altern Med Rev. 2003. Nutritional support for wound healing. PubMed
- [46] N Collins. Adv Skin Wound Care. 2001. Arginine and wound healing. doi:10.1097/00129334-200101000-00010 PubMed
- [47] M Ketteler et al.. Am J Physiol. 1994. Cytokines and L-arginine in renal injury and repair. doi:10.1152/ajprenal.1994.267.2.F197 PubMed
- [48] J E Albina. JPEN J Parenter Enteral Nutr. 1994. Nutrition and wound healing. doi:10.1177/014860719401800417 PubMed
- [49] A Barbul et al.. Surgery. 1990. Arginine enhances wound healing and lymphocyte immune responses in humans. PubMed
- [50] A Barbul et al.. Am J Clin Nutr. 1983. Wound healing and thymotropic effects of arginine: a pituitary mechanism of action. doi:10.1093/ajcn/37.5.786 PubMed
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