Arginine için Wound Healing and Immune Recovery
B Kanıt Bunu büyük ölçüde tutarlı sonuçlarla en az bir randomize çalışma desteklemektedir.Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.
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B
Sonuç
Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.
Key Study Findings
Systematic Review
n=1085
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Dose: None
vs: Standard care or placebo
Outcome: Wound healing time and wound size reduction
Etki: Wound size reduction 18.6-98.2% over 2-20 weeks
None
Popülasyon: Adults with pressure ulcers (15 studies)
Other
PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.
Dose: None
vs: Wild-type mice and control HCECs
Outcome: Corneal epithelial wound healing
Etki: None
None
Popülasyon: Murine corneal wound model and human corneal cells
In Vitro
Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.
Dose: None
vs: None
Outcome: Diabetic wound healing
Etki: None
None
Popülasyon: Diabetic wound model
In Vitro
Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis.
Dose: None
vs: None
Outcome: Diabetic wound healing
Etki: None
None
Popülasyon: Diabetic wound animal model
Other
Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing.
Dose: None
vs: Untreated diabetic wound controls
Outcome: Diabetic wound healing via angiogenesis
Etki: None
None
Popülasyon: Diabetic ulcer mice model
Other
Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5.
Dose: None
vs: None
Outcome: None
Etki: None
None
Popülasyon: Diabetes patients
Key Statistics
8
Çalışmalar
600
Katılımcılar
↑
Positive
B
Derece
Referenced Papers
Journal of controlled …
2025
16 atıf
Journal of colloid …
2025
8 atıf
Investigative ophthalmology & …
2025
4 atıf
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Systematic Review
Wound repair and …
2025
2 atıf
ACS applied materials …
2024
27 atıf
Advanced science (Weinheim, …
2024
15 atıf
Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review.
Systematic Review
Nutrition (Burbank, Los …
2024
12 atıf
ACS applied bio …
2024
4 atıf
Molecular metabolism
2024
3 atıf
Journal of tissue …
2024
2 atıf
Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing.
Other
ACS nano
2023
237 atıf
A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing.
Other
Nature communications
2023
120 atıf
Carbohydrate polymers
2023
86 atıf
International journal of …
2023
76 atıf
Antibacterial self-healing bilayer dressing for epidermal sensors and accelerate wound repair.
Other
Carbohydrate polymers
2023
32 atıf
International journal of …
2023
31 atıf
International journal of …
2023
27 atıf
Biomedical materials (Bristol, …
2023
15 atıf
International journal of …
2023
11 atıf
International journal of …
2022
77 atıf
A Systematic Review of Oral Nutritional Supplement and Wound Healing.
Systematic Review
The Annals of …
2022
31 atıf
Journal of cosmetic …
2022
10 atıf
The use of oral and enteral tube-fed arginine supplementation in pressure injury care: A systematic review and meta-analysis.
Meta-Analysis
Nursing open
2022
9 atıf
The FEBS journal
2022
8 atıf
Advances in experimental …
2021
206 atıf
The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine.
Meta-Analysis
Nutrients
2021
123 atıf
Journal of materials …
2021
36 atıf
Nutricion hospitalaria
2021
20 atıf
The Cochrane database …
2020
33 atıf
International journal of …
2019
265 atıf
Effectiveness of Arginine Supplementation on Wound Healing in Older Adults in Acute and Chronic Settings: A Systematic Review.
Systematic Review
Advances in skin …
2019
18 atıf
Biological trace element …
2017
10 atıf
Nutrition in clinical …
2016
42 atıf
Annals of internal …
2015
110 atıf
Nutrition in clinical …
2014
131 atıf
Critical reviews in …
2012
969 atıf
Current opinion in …
2009
66 atıf
Current opinion in …
2008
240 atıf
Nutrition and wound healing.
Review
Plastic and reconstructive …
2006
98 atıf
Nutrition in clinical …
2005
247 atıf
Arginine and cancer.
Review
The Journal of …
2004
181 atıf
Mini reviews in …
2004
178 atıf
Wound repair and …
2003
306 atıf
Nutrition and wound healing.
Review
The Surgical clinics …
2003
16 atıf
Alternative medicine review …
2003
Advances in skin …
2001
10 atıf
The American journal …
1994
91 atıf
Nutrition and wound healing.
Review
JPEN. Journal of …
1994
72 atıf
The American journal …
1983
135 atıf
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Yaygın Kullanılan Dozajlar
- general:
- 2-3 g/day
- immunesupport:
- 6-9 g/day
Üst sınır: No established UL; typically tolerated at 20 g/day
Araştırmalarda İncelenen Dozajlar
| Dozaj | Süre | Etki | N |
|---|---|---|---|
| None | -- | Positive | 1085 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Negative | -- |
| None | -- | Positive | -- |
En iyi alım zamanı: Between meals
Safety & Side Effects
Bildirilen Yan Etkiler
- ⚠ Gastrointestinal discomfort (bloating, diarrhea, cramps)
- ⚠ Gout exacerbation (increased uric acid production)
- ⚠ Blood pressure changes
- ⚠ Worsening of herpes outbreaks (arginine supports viral replication)
Bilinen Etkileşimler
- ● Antihypertensive medications (additive blood pressure lowering)
- ● PDE5 inhibitors like sildenafil (additive vasodilation)
- ● Anticoagulants (may affect platelet function)
- ● Potassium-sparing diuretics (arginine may increase potassium levels)
Tolere edilebilir üst alım: No established UL; typically tolerated at 20 g/day
Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.
Frequently Asked Questions
Does Arginine help with Wound Healing and Immune Recovery?
Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Arginine may support Wound Healing and Immune Recovery management. Our evidence grade is B (Good Evidence).
How much Arginine should I take for Wound Healing and Immune Recovery?
Studies have used various dosages. A commonly studied range is 2-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Arginine?
Reported side effects may include Gastrointestinal discomfort (bloating, diarrhea, cramps), Gout exacerbation (increased uric acid production), Blood pressure changes, Worsening of herpes outbreaks (arginine supports viral replication). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Arginine and Wound Healing and Immune Recovery?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
References
- [1] Fupeng Li et al.. J Control Release. 2025. Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis. doi:10.1016/j.jconrel.2025.113838 PubMed
- [2] Jialiang Pan et al.. J Colloid Interface Sci. 2025. Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing. doi:10.1016/j.jcis.2025.138423 PubMed
- [3] Qiongjie Cao et al.. Invest Ophthalmol Vis Sci. 2025. PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3. doi:10.1167/iovs.66.1.22 PubMed
- [4] Tim Torsy et al.. Wound Repair Regen. 2025. The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review. doi:10.1111/wrr.70077 PubMed
- [5] Yan Yang et al.. ACS Appl Mater Interfaces. 2024. Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing. doi:10.1021/acsami.3c13072 PubMed
- [6] Qian Zhang et al.. Adv Sci (Weinh). 2024. Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5. doi:10.1002/advs.202405987 PubMed
- [7] Allan Carlos Soares do Espírito Santo et al.. Nutrition. 2024. Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review. doi:10.1016/j.nut.2024.112449 PubMed
- [8] Iniyan Saravanakumar et al.. ACS Appl Bio Mater. 2024. l-Arginine-Loaded Oxidized Isabgol/Chitosan-Based Biomimetic Composite Scaffold Accelerates Collagen Synthesis, Vascularization, and Re-epithelialization during Wound Healing in Diabetic Rats. doi:10.1021/acsabm.4c00729 PubMed
- [9] Ammar A Abdelrahman et al.. Mol Metab. 2024. Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes. doi:10.1016/j.molmet.2024.102020 PubMed
- [10] Tim Torsy et al.. J Tissue Viability. 2024. Effectiveness of glutamine and arginine in wound healing of pressure ulcers: A systematic review protocol. doi:10.1016/j.jtv.2024.03.001 PubMed
- [11] Limin Shang et al.. ACS Nano. 2023. Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing. doi:10.1021/acsnano.3c04134 PubMed
- [12] Jinjian Huang et al.. Nat Commun. 2023. A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing. doi:10.1038/s41467-023-43364-2 PubMed
- [13] Ganzhe Mao et al.. Carbohydr Polym. 2023. Preparation and evaluation of a novel alginate-arginine-zinc ion hydrogel film for skin wound healing. doi:10.1016/j.carbpol.2023.120757 PubMed
- [14] Shuofei Yang et al.. Int J Biol Sci. 2023. Neutrophil Extracellular Traps Delay Diabetic Wound Healing by Inducing Endothelial-to-Mesenchymal Transition via the Hippo pathway. doi:10.7150/ijbs.78046 PubMed
- [15] Asghar Eskandarinia et al.. Carbohydr Polym. 2023. Antibacterial self-healing bilayer dressing for epidermal sensors and accelerate wound repair. doi:10.1016/j.carbpol.2023.121171 PubMed
- [16] Lifeng Zhang et al.. Int J Biol Macromol. 2023. A phellinus igniarius polysaccharide/chitosan-arginine hydrogel for promoting diabetic wound healing. doi:10.1016/j.ijbiomac.2023.126014 PubMed
- [17] Muhammad Hasnain et al.. Int J Biol Macromol. 2023. Microarray needles comprised of arginine-modified chitosan/PVA hydrogel for enhanced antibacterial and wound healing potential of curcumin. doi:10.1016/j.ijbiomac.2023.126697 PubMed
- [18] Hillary Mndlovu et al.. Biomed Mater. 2023. Tannic acid-loaded chitosan-RGD-alginate scaffolds for wound healing and skin regeneration. doi:10.1088/1748-605X/acce88 PubMed
- [19] Shiqi Ye et al.. Int J Biol Sci. 2023. Protein Arginine Methyltransferases Refine the Classification of Clear Cell Renal Cell Carcinoma with Distinct Prognosis and Tumor Microenvironment Characteristics. doi:10.7150/ijbs.80323 PubMed
- [20] Wenjin Ye et al.. Int J Biol Macromol. 2022. Keratin-based wound dressings: From waste to wealth. doi:10.1016/j.ijbiomac.2022.04.216 PubMed
- [21] Ghazal S Daher et al.. Ann Otol Rhinol Laryngol. 2022. A Systematic Review of Oral Nutritional Supplement and Wound Healing. doi:10.1177/00034894211069437 PubMed
- [22] Koo Chul Kwon et al.. J Cosmet Dermatol. 2022. Effects of arginine glutamate (RE:pair) on wound healing and skin elasticity improvement after CO2 laser irradiation. doi:10.1111/jocd.14957 PubMed
- [23] Sahar Cheshmeh et al.. Nurs Open. 2022. The use of oral and enteral tube-fed arginine supplementation in pressure injury care: A systematic review and meta-analysis. doi:10.1002/nop2.974 PubMed
- [24] Jian Qin et al.. FEBS J. 2022. Arginine methylation in the epithelial-to-mesenchymal transition. doi:10.1111/febs.16152 PubMed
- [25] Guoyao Wu et al.. Adv Exp Med Biol. 2021. Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. doi:10.1007/978-3-030-74180-8_10 PubMed
- [26] Elena Arribas-López et al.. Nutrients. 2021. The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine. doi:10.3390/nu13082498 PubMed
- [27] Yang Zhou et al.. J Mater Chem B. 2021. Advances and impact of arginine-based materials in wound healing. doi:10.1039/d1tb00958c PubMed
- [28] Rosa María Martínez García et al.. Nutr Hosp. 2021. [Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot]. doi:10.20960/nh.03800 PubMed
- [29] Zena Eh Moore et al.. Cochrane Database Syst Rev. 2020. Nutritional interventions for treating foot ulcers in people with diabetes. doi:10.1002/14651858.CD011378.pub2 PubMed
- [30] Martina Barchitta et al.. Int J Mol Sci. 2019. Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. doi:10.3390/ijms20051119 PubMed
- [31] Kara L Schneider et al.. Adv Skin Wound Care. 2019. Effectiveness of Arginine Supplementation on Wound Healing in Older Adults in Acute and Chronic Settings: A Systematic Review. doi:10.1097/01.ASW.0000579700.20404.56 PubMed
- [32] Ali Said Durmus et al.. Biol Trace Elem Res. 2017. Arginine Silicate Inositol Complex Accelerates Cutaneous Wound Healing. doi:10.1007/s12011-016-0857-2 PubMed
- [33] Jayshil J Patel et al.. Nutr Clin Pract. 2016. When Is It Appropriate to Use Arginine in Critical Illness? doi:10.1177/0884533616652576 PubMed
- [34] Emanuele Cereda et al.. Ann Intern Med. 2015. A nutritional formula enriched with arginine, zinc, and antioxidants for the healing of pressure ulcers: a randomized trial. doi:10.7326/M14-0696 PubMed
- [35] David C Evans et al.. Nutr Clin Pract. 2014. Nutrition optimization prior to surgery. doi:10.1177/0884533613517006 PubMed
- [36] Charles D Mills. Crit Rev Immunol. 2012. M1 and M2 Macrophages: Oracles of Health and Disease. doi:10.1615/critrevimmunol.v32.i6.10 PubMed
- [37] Sabine Ellinger et al.. Curr Opin Clin Nutr Metab Care. 2009. Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies. doi:10.1097/MCO.0b013e328331a5b5 PubMed
- [38] Antonio C L Campos et al.. Curr Opin Clin Nutr Metab Care. 2008. Assessment and nutritional aspects of wound healing. doi:10.1097/MCO.0b013e3282fbd35a PubMed
- [39] Meghan Arnold et al.. Plast Reconstr Surg. 2006. Nutrition and wound healing. doi:10.1097/01.prs.0000225432.17501.6c PubMed
- [40] Joyce K Stechmiller et al.. Nutr Clin Pract. 2005. Arginine supplementation and wound healing. doi:10.1177/011542650502000152 PubMed
- [41] D Scott Lind. J Nutr. 2004. Arginine and cancer. doi:10.1093/jn/134.10.2837S PubMed
- [42] Betty C Tong et al.. Mini Rev Med Chem. 2004. Cellular and physiological effects of arginine. doi:10.2174/1389557043403305 PubMed
- [43] Maria B Witte et al.. Wound Repair Regen. 2003. Arginine physiology and its implication for wound healing. doi:10.1046/j.1524-475x.2003.11605.x PubMed
- [44] Jeremy Z Williams et al.. Surg Clin North Am. 2003. Nutrition and wound healing. doi:10.1016/S0039-6109(02)00193-7 PubMed
- [45] Douglas MacKay et al.. Altern Med Rev. 2003. Nutritional support for wound healing. PubMed
- [46] N Collins. Adv Skin Wound Care. 2001. Arginine and wound healing. doi:10.1097/00129334-200101000-00010 PubMed
- [47] M Ketteler et al.. Am J Physiol. 1994. Cytokines and L-arginine in renal injury and repair. doi:10.1152/ajprenal.1994.267.2.F197 PubMed
- [48] J E Albina. JPEN J Parenter Enteral Nutr. 1994. Nutrition and wound healing. doi:10.1177/014860719401800417 PubMed
- [49] A Barbul et al.. Surgery. 1990. Arginine enhances wound healing and lymphocyte immune responses in humans. PubMed
- [50] A Barbul et al.. Am J Clin Nutr. 1983. Wound healing and thymotropic effects of arginine: a pituitary mechanism of action. doi:10.1093/ajcn/37.5.786 PubMed
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